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BackgroundChronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are characterized by persistent airway inflammation and airflow limitation. Measuring airway inflammation may be of value both in research and clinical practice. Calprotectin, a protein associated with neutrophil activation, serves as a potential biomarker for airway inflammation. This study evaluates the performance o

Hypothalamic inflammation underlies diet-induced obesity and diabetes in rodent models. While diet normalization largely allows for recovery from metabolic impairment, it remains unknown whether long-term hypothalamic inflammation induced by obesogenic diets is a reversible process. In this study, we aimed at determining sex specificity of hypothalamic neuroinflammation and gliosis in mice fed a f

Background Patients with acute coronary syndrome (ACS) are often admitted to monitored wards due to the risk of complications. Several risk prediction scores exist, but their use in the emergency department (ED) is limited. We aimed to compare the ability of existing risk scores with a new logistic regression model in predicting complications in ACS patients. Methods This was a secondary analysis

Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence, these systems are now capable of adaptive decision-making and real-time experimental control. Here, we introduce a theoretical framework that reconceptualises sma

Ever since the birth of the film medium, the Sámi people, indigenous to Fennoscandia, have been depicted on film. These early films are ethnographic, made from an outsider perspective, depicting the Sámi as exotic and simple. However, in the 1970s, the Sámi became more involved in the filmmaking process, and in 1987, the first Sámi film, Pathfinder, was made. This shift to Sámi self-representation

Background Approximately one-third-of patients with transient new-onset atrial fibrillation (AF) during hospitalization for noncardiac surgery or medical illness will have recurrent AF within 1 year when assessed using two 14-day ECG monitors. The proportion of patients that would be diagnosed with recurrent AF with less monitoring is unknown. Methods We used data from a prospective cohort of part

This dissertation is about social change ‘and’, ‘with’, as well as ‘through’ food. It examines the rise and expansion of novel approaches to veganism and plant-based lifestyles in the Sino-cultural sphere by foregrounding the assemblage of actors (human and nonhuman) at the forefront of this phenomenon. While East Asia, and more specifically Sinophone societies like China and Taiwan, have long-est

How can different value chain actors mitigate threats or benefit from moments of volatility? This question has become essential as global value chains are restructuring, with policymakers and management scholars calling for increasing value chain resilience. Surveying geographers’ recent contributions, this paper develops a geographical political economy of value chain resilience, which helps expl

Over-reliance in high-risk industries on prescriptive emergency procedures and the capacity of high-fidelity simulation has initiated the search for new steps for training for unexpected and escalating situations. This chapter outlines a theoretical framework describing the adaptive and flexible competencies that add up to an organisation’s resilience in escalating situations. To make the framewor

Background: Diffuse large B-cell lymphoma (DLBCL) exhibits immunological heterogeneity that influences outcomes of immunochemotherapy, with CD8+ T cells playing a critical role in patient prognosis. Methods: We integrated single-cell and bulk transcriptome data to establish a CD8⁺ T cell–associated prognostic signature. Single-cell RNA sequencing data from 29 samples (28 individuals), including DL

Inflammation and infection remain unmet challenges in wounds of various etiologies, delaying healing, impacting quality of life, and increasing healthcare costs. The thrombin-derived C-terminal peptide TCP-25 has demonstrated dual anti-inflammatory and antibacterial activities in animal wound infection models, thereby promoting healing, highlighting its therapeutic potential as a wound treatment.

Immune thrombocytopenia (ITP) is characterized by the overproduction of antiplatelet autoantibodies. Although B-cell depletion therapies show promise in ITP, their high relapse rates suggest a potential de novo breakdown of tolerance during an early stage of B-cell development. Here, we investigated how central B-cell tolerance mechanisms affect autoantibody production in ITP. Paired single-cell R