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Decongestants and antihistamines for acute otitis media in children
RATIONALE: Acute otitis media (AOM) is one of the most common bacterial infections in children worldwide, and the most common reason for prescribing antibiotics. Although serious complications (e.g. mastoiditis or meningitis) are rare, the infection causes acute pain and can lead to hearing impairment. Since AOM often resolves spontaneously, current treatment guidelines recommend an approach of wa
Adaptive Gen-AI Guidance in Virtual Reality : A Multimodal Exploration of Engagement in Neapolitan Pizza-Making
Virtual reality (VR) offers promising opportunities for procedural learning, particularly in preserving intangible cultural heritage. Advances in generative artificial intelligence (Gen-AI) further enrich these experiences by enabling adaptive learning pathways. However, evaluating such adaptive systems using traditional temporal metrics remains challenging due to the inherent variability in Gen-A
How academic developers can use modelling to promote active learning and co-creation
One purpose of academic development work is to ensure university teachers use evidence-based teaching approaches. Academic developers often teach colleagues about the latest teaching approaches and model these to enable teachers to see the use of evidence-based methods in practice, aiming to inspire teachers to adopt similar approaches. Active learning and co-creation are approaches that have been
Exploring housing trajectories in later life and their links to demographic, socioeconomic and health characteristics : the register RELOC-AGE study
INTRODUCTION: In Sweden, most older adults continue to age in dwellings they have lived in for many years, with a small proportion relocating. Longitudinal studies examining relocation histories, especially among younger old adults and those beyond frail populations, are scarce. This study aimed to describe individuals who stayed in their homes (stayers) and those who relocated (movers) while iden
Identification of a novel gene associated with group B Streptococcus persister cell formation and biofilm production
Antibiotic persistence arises when a subset of cells in an otherwise susceptible bacterial population temporarily exhibits elevated tolerance to bactericidal antibiotics. While significant progress has been made in elucidating persister mechanisms, much of this research has focused on Gram-negative bacteria, and these findings are not always applicable to Gram-positive species. This study explores
Greta Thunberg and the transnational youth elite in global climate politics : myth or reality?
Greta Thunberg has gained increasing attention in global climate politics, in particular since the Fridays for Future movement she initiated in 2018. Attention has also come with criticism, denouncing her for being part of a transnational youth climate elite made up of privileged youth. However, does such an elite really exist, and what does it mean for global climate politics? This article invest
World on the brink : Will history bring us full circle?
Policy implications of energy-water-carbon emissions nexus based on national policies in China
To address the absence of the comprehensive analysis of energy-water-carbon emissions nexus between large-scale economies and different industries and the inability to predict policy impacts across industrial hierarchies, this study develops a novel framework integrating environmentally-extended multi-regional input-output analysis with structural decomposition analysis and policy-driven scenario
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This article offers a critical review of the history of international law, questioning its Eurocentric and state-centric foundations. From the perspective of Third World Approaches to International Law (TWAIL), it highlights the constitutive role of colonialism in shaping the international legal order, particularly in doctrines such as sovereignty. It examines the work of Francisco de Vitoria, who
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Age-Specific Diagnostic Panorama Among People With Intellectual Disabilities in Comparison With the General Population : A Longitudinal Register Study (IDcare)
BACKGROUND: People with intellectual disabilities (ID) are known to have a higher risk for a wide range of health conditions compared to the general population. However, there is little research comparing a more comprehensive range of diseases and conditions at different ages. Therefore, the aim of this study was to explore the overall age-specific diagnostic pattern among people with ID compared
Securing the future : navigating blockchain challenges in procurement 4.0 for ensuring food security
PurposeBlockchain technology (BCT) is a novel and disruptive innovation that can transform procurement processes in various industries, including the food sector. BCT can offer benefits such as transparency, traceability, security, and efficiency for procuring food products, which are essential for ensuring food security and quality. However, BCT faces several challenges that hinder its adoption a
Public procurement and local food for sustainable governance : insights from Dalarna, Sweden
This paper explores an initiative by a local government in Rättvik, Sweden, to increase the consumption of local food in the municipal kitchens. It explores public procurement of local food as a way for local governments to address sustainability and climate goals while meeting residents’ demand for ‘good’ local food. Through a qualitative case study reviewing food and procurement policies across
What Does Criminal Law See When It Recognises Something as Sexual? : On the Legal Interests Involved in Sexual Offences
Challenges in managing driving licence legislation when using B-Phosphatidylethanol to identify high levels of alcohol use in primary care patients : A qualitative study
Warming‒wetting and continentality co-modulate the effect of desertification on permafrost degradation on the Qinghai‒Xizang Plateau
Permafrost degradation and desertification have been identified as two major land surface processes occurring on the Qinghai‒Xizang Plateau. However, the effect of desertification on permafrost degradation remains poorly understood. In this study, land surface process simulations are used to demonstrate that climate change, characterised by increased warming‒wetting trends alongside reduced contin
Venetoclax is effective for chronic myelomonocytic leukemia blastic transformation with RUNX1 mutation
Background: Chronic myelomonocytic leukemia is a clonal hematological disorder with an inherent risk of transformation to acute myeloid leukemia. Recently, there has been exponential discovery of molecular abnormalities in patients with chronic myelomonocytic leukemia. Some of these mutations independently contribute to a higher risk of transformation and result in inferior overall survival. Treat
Clinical Utility of Flow Cytometry for Detection of Anti-Jkb IgM in Acute Haemolytic Transfusion Reaction
Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jkb IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A+/Rh-/Jkb+/c- transfusion, he developed acute respiratory failure and a fever. Although he had tested negative in routine screening tests
Genetic and Pathological Characteristics of Frontotemporal Dementia with Right Anterior Temporal Predominance: A Multicenter Retrospective Cohort Study
BACKGROUND: Frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominant atrophy is an emerging area of interest. Recent findings by the International Working Group (IWG) have identified this subtype as having a distinct clinical profile within the FTD spectrum (Ulugut et al., 2024, A&D). However, its genetic and pathological underpinnings remain unexplored in large, mult
