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Impact of missing data on bias and precision when estimating change in patient-reported outcomes from a clinical registry

Clinical registries, which capture information about the health and healthcare use of patients with a health condition or treatment, often contain patient-reported outcomes (PROs) that provide insights about the patient’s perspectives on their health. Missing data can affect the value of PRO data for healthcare decision-making. We compared the precision and bias of several missing data methods whe

https://www.lupop.lu.se/article/impact-missing-data-bias-and-precision-when-estimating-change-patient-reported-outcomes-clinical - 2025-11-22

Registry-Based Medical Research: Data Dredging or Value Building to Quality of Care?

Registry-based medical research is an important tool in assessing health care interventions in the general population. Observational studies are used to establish effectiveness whereas randomized clinical trials assess efficacy in an experimental manner targeting a carefully selected population of patients. Medical registries may be office or hospital based, state/provincial, national, or more rec

https://www.lupop.lu.se/article/registry-based-medical-research-data-dredging-or-value-building-quality-care - 2025-11-22

Data verification of nationwide clinical quality registries

Clinical auditing is an emerging instrument for quality assessment and improvement.Moreover, clinical registries facilitate medical research as they provide ‘real world’ data. It is importantthat entered data are robust and reliable. The aim of this study was to describe the evolving procedureand results of data verication within the Dutch Institute for Clinical Auditing (DICA). New publication i

https://www.lupop.lu.se/article/data-verification-nationwide-clinical-quality-registries - 2025-11-22

Risk and outcome of hepatocellular carcinoma in liver cirrhosis in Southern Sweden: a population-based study

Liver cirrhosis is a risk factor for hepatocellular carcinoma (HCC). While the HCC risk is thought to be highest in hepatitis B and hepatitis C, the risk in other cirrhosis etiologies is not fully established. Therefore, we aimed to study the risk and outcome of HCC in alcoholic cirrhosis compared to cirrhosis of other etiologies, in Sweden. New publication in Scandinavian Journal of Gastroenterol

https://www.lupop.lu.se/article/risk-and-outcome-hepatocellular-carcinoma-liver-cirrhosis-southern-sweden-population-based-study - 2025-11-22

Contextualizing selection bias in Mendelian randomization: how bad is it likely to be?

Selection bias affects Mendelian randomization investigations when selection into the study sample depends on a collider between the genetic variant and confounders of the risk factor–outcome association. However, the relative importance of selection bias for Mendelian randomization compared with other potential biases is unclear. New publication in International Journal of Epidemiology.Read more

https://www.lupop.lu.se/article/contextualizing-selection-bias-mendelian-randomization-how-bad-it-likely-be - 2025-11-22

Barriers and Opportunities for Use of Patient Registries in Medicines Regulation

The European Medicines Agency (EMA) established the Patient Registry Initiative to explore ways of supporting the use of patient registries in generating high-quality data for regulatory decision making and to enable a systematic approach to their use. We review barriers and opportunities for using patient registries in medicines regulation. A key aspect is that early discussions between all parti

https://www.lupop.lu.se/article/barriers-and-opportunities-use-patient-registries-medicines-regulation - 2025-11-22

Bayesian Methods for Exposure Misclassification Adjustment in a Mediation Analysis

Soil-transmitted helminth infections have been found to be associated with child development. The objective was to investigate hemoglobin levels and malnutrition as mediators of the association between Ascaris infection and intelligence quotient (IQ) scores in children. New publication in Epidemiology.Read more here.

https://www.lupop.lu.se/article/bayesian-methods-exposure-misclassification-adjustment-mediation-analysis - 2025-11-22

The what, when and how of orthopaedic registers: an introduction into register-based research

Establishment of orthopaedic registers started in 1975 and many registers have been initiated since. The main purpose of registers is to collect information on patients, implants and procedures in order to monitor and improve the outcome of the specific procedure. New publicatoin in Efort.Read more here

https://www.lupop.lu.se/article/what-when-and-how-orthopaedic-registers-introduction-register-based-research-0 - 2025-11-22

Learning what works: a framwork for causal inference from observational data

This is an open seminar with professor Miguel Hernán A 3 half-day seminar on Causal Inference with Miguel Hernán, professor of Biostatistics and Epidemiology at Harvard School of Public Health.The scheduel is as follow:Monday May 6 at 1-5PMTuesday May 7 at 1-5PMWednesday May 8 at 9-12AMLocation: Arvid Carlsson, Acadmicum, GothenburgRead more here 

https://www.lupop.lu.se/article/learning-what-works-framwork-causal-inference-observational-data - 2025-11-22

Quality indicators and their regular use in clinical practice: results from a survey among users of two cardiovascular National Registries in Sweden

Most respondents used quality indicators from the two cardiovascular NQRs infrequently (<3 times/year). The results indicate that linking registration of quality indicators to using them for QI activities increases their routine use and makes them meaningful tools for professionals. New publication in International Journal for Quality in Health CareRead more here

https://www.lupop.lu.se/article/quality-indicators-and-their-regular-use-clinical-practice-results-survey-among-users-two - 2025-11-22

Patient-reported outcome and experience measures for diabetes: development of scale models, differences between patient groups and relationships with cardiovascular and diabetes complication risk factors, in a combined registry and survey study in Sweden.

The questionnaire measures and detects differences in patient well-being, abilities and judgements of diabetes care, and identifies areas for improvement. To further improve diabetes care, we conclude that patient-reported measures are important supplements to cardiovascular and diabetes complication risk factors, reflecting patient experiences of living with diabetes and diabetes care. New public

https://www.lupop.lu.se/article/patient-reported-outcome-and-experience-measures-diabetes-development-scale-models-differences - 2025-11-22

Causal models adjusting for time-varying confounding—a systematic review of the literature

There has been marked growth in reports addressing exposure-affected time-varying confounding. This was driven by work in a small number of topic areas, with other areas showing relatively little uptake. In addition, despite developments in more advanced methods such doubly robust techniques and estimation via machine learning, implementation has been largely concentrated on the simpler, yet poten

https://www.lupop.lu.se/article/causal-models-adjusting-time-varying-confounding-systematic-review-literature - 2025-11-22