The Case for Case–Cohort: An Applied Epidemiologist’s Guide to Reframing Case–Cohort Studies to Improve Usability and Flexibility
Published 20 June 2022 When research questions require the use of precious samples, expensive assays or equipment, or labor-intensive data collection or analysis, nested case–control or case–cohort sampling of observational cohort study participants can often reduce costs. These study designs have similar statistical precision for addressing a singular research question, but case–cohort studies ha