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Theme: "The future of Swedish register-based research" By the end of 2018 the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM), funded by the Swedish Research Council, has been active for 10 years. This will be acknowledged by a free open national one-day symposium in Stockholm 16 May reflecting on how the achievements and experiences of SIMSAM and other par
https://www.lupop.lu.se/article/10-year-symposium-simsam - 2025-08-25
Consecutive patients with early RA (symptom duration <12 months) were followed according to a structured programme and examined with dual-energy X-ray absorptiometry (DXA) at inclusion and after 2, 5 and 10 years. Mean Z-scores over the study period were estimated using mixed linear effect models. Changes in Z-scores between follow-up visits were analysed using paired T-tests. New publication in R
https://www.lupop.lu.se/article/changes-bone-mineral-density-over-10-years-patients-early-rheumatoid-arthritis - 2025-08-25
It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. New publication in JAHA
https://www.lupop.lu.se/article/risk-stroke-patients-atrial-fibrillation-associated-stroke-siblings-nationwide-study - 2025-08-25
We performed whole-exome sequencing in 22 probands, under 56 years at their first ischemic stroke episode, from multi-incident stroke families. With the use of a comprehensive stroke-gene panel, we searched for variants in stroke-related genes. The probands’ clinical stroke subtype was related to clinical characteristics previously associated with pathogenic variants in these genes. New publicatio
https://www.lupop.lu.se/article/whole-exome-sequencing-22-young-ischemic-stroke-patients-familial-clustering-stroke - 2025-08-25
Chills and vomiting have traditionally been associated with severe bacterial infections and bacteremia. However, few modern studies have in a prospective way evaluated the association of these signs with bacteremia, which is the aim of this prospective, multicenter study. Patients presenting to the emergency department with at least one affected vital sign (increased respiratory rate, increased he
Disease prevalence proportions were generally underestimated in the absence of IPPW but became markedly closer to population values after IPPW using sociodemographic variables. We found limited evidence of selective participation bias in association estimates, but IPPW improved external validity when bias was present. New publication in Journal of Clinical Epidemiology
Polypharmacy and excessive polypharmacy were evaluated using data extracted from the Swedish Prescribed Drug Register between 2006 and 2014. Polypharmacy was defined as being exposed to five or more drugs and excessive polypharmacy was defined as being exposed to 10 or more drugs during 1 month respectively. Average annual percent change (AAPC) was calculated using Joinpoint Statistical Software.
https://www.lupop.lu.se/article/increasing-trend-prevalence-polypharmacy-sweden-nationwide-register-based-study - 2025-08-25
Obesity among children and adolescents is a worldwide public health concern. Type 1 diabetes (T1D) and type 2 diabetes (T2D) incidence are increasing, with heredity and socioeconomic status as possible risk factors. How these factors affect the risk of childhood obesity remains unclear. The aim of this study was to investigate the association between obesity and parental diabetes among 12-year-old
https://www.lupop.lu.se/article/impact-parental-diabetes-prevalence-childhood-obesity - 2025-08-25
The world of sports has a complex association to problem gambling, and the sparse research examining problem gambling in athletes has suggested an increased prevalence and particularly high male predominance. The present study aimed to study frequency and correlates of problem gambling in populations with moderate to high involvement in fitness or physical exercise. New publication in Int J. Envir
https://www.lupop.lu.se/article/problem-gambling-fitness-world-general-population-web-survey - 2025-08-25
The aim of this study was to investigate the risk of developing preeclampsia (PE) associated with gestational exposure to ambient air pollutants in southern Sweden, a low-exposure area. We used a cohort of 43,688 singleton pregnancies and monthly mean exposure levels of black carbon (BC), local and total particulate matter (PM2.5 and PM10), and NOX at the maternal residential address estimated by
Due to the demographic challenge in most countries it is important to consider making work life sustainable. A sustainable work life is of importance in all age groups when working life will be extended to a higher age. New publication in Applied Ergonomics
https://www.lupop.lu.se/article/sustainable-working-life-all-ages-swage-model - 2025-08-25
Free course for PhD students and junior researchers This free course, funded by NordForsk, will provide knowledge in methodology and hands-on experience on conducting register-based research across the Nordic countries with a focus on pharmacoepidemiology.Target group: PhD students and junior researchers.Participants can apply for reimbursement of travel and accommodation expenses.The course will
https://www.lupop.lu.se/article/pharmacoepidemiology-drug-use-and-safety - 2025-08-25
Zoom meeting explaining the process of applying to the Knut and Alice Wallenberg Foundation Read more, and sign up, here.
https://www.lupop.lu.se/article/information-meeting-knut-and-alice-wallenberg-foundation-0 - 2025-08-25
The study population included all adults aged 18 years and older in Sweden, living and deceased, 6,690,598 in the first-generation and 6,683,125 in the second-generation sub-study. Epilepsy was defined as having at least one registered diagnosis of epilepsy in the National Patient Register. The incidence of epilepsy in different immigrant groups, using Swedish-born as referents, was assessed by Co
To evaluate the access to human rights of persons with disabilities who use prosthetic and orthotic assistive devices, and to compare groups of participants in terms of gender, residential area, income, and type and level of assistive device. The addressed areas were rights to: health, a standard of living adequate for health, education, marry and establish a family, vote, and work. New publicatio
This study investigates specialist healthcare visits of older people with intellectual disability ID having affective and anxiety diagnoses in comparison with the general population, as well as across different levels of ID, behavioural impairment, and living in special housing in Sweden. New publication in Aging & Mental Health
The FAIR guiding principles are exactly that; a guide to create reusable research objects. FAIR is not a new standard; is not a top down requirement; is not an all-or-nothing binary state (FAIR or not FAIR). The FAIR principles were conceived and designed as a resource for optimal choices to be made during many aspects of data and tool generation as well as (re)use and long term stewardship. New p
https://www.lupop.lu.se/article/fair-principles-first-generation-implementation-choices-and-challenges - 2025-08-25
This study aimed to investigate the occurrence of suicidal ideation and associated factors in older persons with dementia living at home in eight European countries, and its association with quality of life. Furthermore, changes in suicidal ideation over time were investigated. New publication in Aging & Mental Health
Research indicates that occupation is important for well-being in people with mental illness, but this has not been extensively studied among those with severe psychiatric disabilities. Social contacts may possibly play a more vital role for them. This study aimed to explore how aspects of occupation and social interaction were related with well-being factors in that group, while controlling for t
As at December 31, 2018, 5,762 patients, 7,776 amputations, 2,658 prosthetic supplies, 1,848 baselines, and 2,006 follow-ups were registered. 61% of the patients were male, and mean age by the time of the first registered amputation was 74 years (SD 14). Women were older, more frequently had vascular disease without diabetes and more often underwent amputation at a higher level compared with men (
