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PATRIK MEDSTRAND Patrik Medstrand_LUCRIS Patrik Medstrand_PubMed

https://www.virology.lu.se/clinical-virology/publications - 2025-11-21

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https://www.virology.lu.se/clinical-virology/collaborators - 2025-11-21

Patrik Medstrand, Professor E-post: patrik [dot] medstrand [at] med [dot] lu [dot] se (patrik[dot]medstrand[at]med[dot]lu[dot]se) Professor vid Klinisk virologi, Malmö Telefon: +46 46 222 14 89 Mobil: +46 70 841 57 97 Rumsnummer: BMC B1354b Professor vid EpiHealth: Epidemiology for Health Chef vid Klinisk virologi, Malmö Forskargruppschef vid Klinisk virologi, Malmö

https://www.virology.lu.se/clinical-virology/contact - 2025-11-21

HIV-1 and HIV-2 host interactions - - Lund University Karlsson I, Tingstedt JL, Sahin GÖ, Hansen M, Szojka Z, Buggert M, Biague A, Da Silva Z, Månsson F, Esbjörnsson J, Norrgren H, Medstrand P, Fomsgaard A*, and Jansson M*; Sweden-Guinea-Bissau Cohort Research Group. Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted ADCC Identified in HIV-2-Infected Indivi

https://www.virology.lu.se/hiv-host-interactions/marianne-jansson - 2025-11-21

Marianne Jansson Marianne Jansson_LUCRISMarianne Jansson_PubMed  

https://www.virology.lu.se/hiv-host-interactions/publications - 2025-11-21

For many double stranded (ds) DNA viruses the viral genome is actively packaged into the virus capsid by a powerful molecular motor. This results in an energetically unfavorable state of the packaged genome, creating tens of atmospheres internal pressure inside the virion. Using a new calorimetric assay to determine the activation energy barriers associated with genome loss in response to elevated

https://www.virus-biophysics.lu.se/covers-highlights-0 - 2025-11-21

 For many double stranded (ds) DNA viruses the viral genome is actively packaged into the virus capsid by a powerful molecular motor. This results in an energetically unfavorable state of the packaged genome, creating tens of atmospheres internal pressure inside the virion. Using a new calorimetric assay to determine the activation energy barriers associated with genome loss in response to elevate

https://www.virus-biophysics.lu.se/covers-movies-and-highlights - 2025-11-21

ALEX EVILEVITCH RESEARCH GROUP We are always interested in reviewing applications from MSc students, prospective PhD students and postdocs.   Project description    Herpesviruses are a leading cause of human viral disease. Herpesviruses consist of a double-stranded DNA genome contained within a protein shell, termed the capsid, that is surrounded by an unstructured protein layer and a lipid-envelo

https://www.virus-biophysics.lu.se/open-positions-0 - 2025-11-21

Virus Biophysics Virus Biophysics is a rather new field that seeks to define the physical mechanisms controlling virus development. This knowledge can provide information essential to the rational design of new antiviral strategies with less specificity for a limited number of viruses. Furthermore, biological and physical simplicity relative to other biological systems have made viruses an attract

https://www.virus-biophysics.lu.se/research-overview - 2025-11-21

News and Events January 9, 2024 , Physics World "Viruses change structure at the temperature of the human body to better infect us". If you want to know in simple words a possible mechanism of viral genome delivery, read more in this link (it opens a new webpage).November 8, 2023,  Lund University press release on our pioneering study published in PNAS showing how temperature triggers release of v

https://www.virus-biophysics.lu.se/node/137 - 2025-11-21

Herpes Simplex 1 pressurized DNA release into a cell nucleus. DNA packaging and capsid reinforcement  Illustration and poem inspired by graduate student Krista Freeman's contributions to “The Invisible Jazz Experimental Laboratories”, hosted by The Space Upstairs in Pittsburgh, PA."I've optimized my eyes to fill my brain with dissonance in a balance. The information is a bomb, every fact a potenti

https://www.virus-biophysics.lu.se/movies-artwork - 2025-11-21

Our Biophysical ToolsOur research group investigates mechanics of viral replication, virus-host interactions, virus assembly and disassembly within the host. Specifically, we investigate energetics, structure and mobility of the intra-capsid genome as well as mechanical properties of viral capsids, influenced by changes in physiological environment that are important for viral replication. Main to

https://www.virus-biophysics.lu.se/methods-and-techniques - 2025-11-21

  Principal Investigator: Alex Evilevitch, PhDProfessor of Cell Biology Email: Alex [dot] Evilevitch [at] med [dot] lu [dot] se   Lab photos    Postdocs   José Ramón Villanueva Valencia, PhDEmail: jose_ramon [dot] villanueva-valencia [at] med [dot] lu [dot] se (jose_ramon[dot]villanueva-valencia[at]med[dot]lu[dot]se)    Santosh Gawali, PhD Email: santosh [dot] gawali [at] med [dot] lu [dot] se   G

https://www.virus-biophysics.lu.se/people - 2025-11-21

Alex Evilevitch Research Group We are always interested in reviewing applications from MSc students, prospective PhD students and postdocs.Project description  Herpesviruses are a leading cause of human viral disease. Herpesviruses consist of a double-stranded DNA genome contained within a protein shell, termed the capsid, that is surrounded by an unstructured protein layer and a lipid-envelope. H

https://www.virus-biophysics.lu.se/open-positions - 2025-11-21

https://www.virus-biophysics.lu.se/teaching - 2025-11-21

January 9, 2024 , Physics World "Viruses change structure at the temperature of the human body to better infect us". https://physicsworld.com/a/viruses-change-structure-at-the-temperature-of-the-human-body-to-better-infect-us/  November 8, 2023,  Lund University press release on our pioneering study published in PNAS showing how temperature triggers release of viral genome by changing the form and

https://www.virus-biophysics.lu.se/news-0 - 2025-11-21

To see Prof. Alex Evilevitch Open Researcher and Contributor ID (ORCID), click the link below (it opens another website):https://orcid.org/0000-0002-0245-9574   Below, there is the full list of publication of Prof. Alex Evilevitch. It links to another webpage related to the publisher.Villanueva Valencia J. R.,  Li D.,  Casjens S. R.,  Evilevitch A., "‘SAXS-osmometer’ method provides measurement of

https://www.virus-biophysics.lu.se/publications - 2025-11-21

We use atomic force microscopy (AFM) nano-indentation method to measure DNA mobility in the capsid. The mobility of DNA packaged inside the HSV-1 capsid is measured by recording the force resisting the capsid indentation when the AFM tip is brought into contact with the DNA-filled capsid in solution. Force resisting the AFM tip indentation of the capsid is recorded as the force-distance curve. Cap

https://www.virus-biophysics.lu.se/methods-and-techniques/atomic-force-microscopy - 2025-11-21

We use cryo electron microscopy (cryo-EM) and image reconstruction to examine the virion structure at subnanometer resolution. We also analyze structure and density of viral DNA packaged in a capsid.  Figure: Cutaway views from cryo-EM reconstructions of (A) HSV-1 C-capsid and (B) phage lambda procapsid and mature DNA-filled lambda capsid. HSV-1 and lambda phage capsids are shown to scale. Owing t

https://www.virus-biophysics.lu.se/methods-and-techniques/cryo-electron-microscopy - 2025-11-21

The isothermal titration calorimetry (ITC) provides the most direct method to measure the internal energy of the confined viral genome. In order to experimentally dissect the thermodynamic determinants of viral DNA packaging and ejection energetics, we were first to use ITC to directly measure the heat released by DNA ejection from a virus capsid. This approach allows one to address experimentally

https://www.virus-biophysics.lu.se/methods-and-techniques/microcalorimetry - 2025-11-21