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Intravoxel incoherent motion (IVIM) is sensitive to tissue diffusion and perfusion and has spurred great interest in various pathologies such as prostate cancer. However, poor repeatability and reproducibility of IVIM parameters hamper its wide-scale adoption in the clinics. To address this, improvements to the IVIM data acquisition and analysis are necessary. The purpose of this study was to deve
Oral epithelial cells monitor microbiome composition and initiate immune response upon dysbiosis, as in the case of Candida imbalances. Candida species, such as C. albicans and C. parapsilosis, are the most prevalent yeasts in the oral cavity. Comparison of healthy oral epithelial cell responses revealed that while C. albicans infection robustly activated inflammation cascades, C. parapsilosis pri
In recent years, microbiome studies have revealed that Candida species are common colonizers of the human skin. The distribution of species, however, varies greatly. Although C. parapsilosis is more likely to resemble skin commensals, opinions are divided, and discrepancies are present regarding C. albicans that is also often associated with cutaneous candidiasis. Therefore, we aimed to thoroughly
Exposure to e-cigarette aerosols, particulate matter with aerodynamic diameter ≤2.5 µm (PM2.5) and respiratory viruses rarely occurs in isolation, but rather in complex polyexposure contexts during daily life. On a cellular and molecular level, vaping induces a distinct lipid-laden macrophage phenotype, alters pulmonary neutrophilic infiltration and impairs epithelial differentiation and ciliary f
Oral squamous cell carcinoma (OSCC) is associated with oral Candida albicans infection, although it is unclear whether the fungus promotes the genesis and progression of OSCC or whether cancer facilitates fungal growth. In this study, we investigated whether C. albicans can potentiate OSCC tumor development and progression. In vitro, the presence of live C. albicans, but not Candida parapsilosis,
Background:The Strengths and Difficulties Questionnaire (SDQ) measures behavioral problems among children and adolescents. Prior research in Sweden has included child self-report or parent ratings from community or population data.Objective:To provide child-reported and parent-rated SDQ norms for 11- to 16-year-olds, as well as data on child–parent agreement and parental sociodemographic correlate
Basal cell carcinoma (BCC) is the most common form of skin cancer with the current diagnostic procedures relying on surgical excisions and histopathological analyses. Incomplete removal of the tumor necessitates additional surgery, which is both costly and time-consuming. To address this, non-invasive diagnostic techniques capable of determining the dimensions of skin cancer preoperatively are urg
Photocatalytic nitrogen reduction requires the concerted transfer of six electrons and six protons, where inefficient electron utilization and proton supply represent the critical limiting factors for proton-coupled electron transfer in this process. A key challenge lies in hole accumulation within photocatalysts, as hole transfer typically proceeds 2 to 3 orders of magnitude more slowly than elec
Previous studies revealed that grammatical gender may shape perception and categorisation, yet the extent of this influence remains unclear, specifically in simultaneous bilinguals with two gendered languages. This pre-registered ERP study investigates how two partially contrasting grammatical gender systems modulate perception in Ukrainian-Russian bilinguals. Twenty-six participants completed a n
Foraminiferal shells are abundant in marine sediments, well preserved, and morphologically sensitive to environmental conditions, making them widely used archives of past marine environments and oceanographic changes. In particular, foraminiferal pore traits are promising proxies for past ocean oxygenation. However, conventional 2D measurements from limited shell regions may obscure chamber-wise a
Objective: To examine the extent to which epididymo-orchitis or urinary tract infections (UTI) may precede testicular cancer (TC) in Sweden. Methods and analysis: We conducted a nationwide, open-cohort study including 8 382 433 men between 1964 and 2018. Standardised incidence ratios (SIR) with 95% CIs were calculated to compare TC incidence rates in men diagnosed with epididymo-orchitis or UTI—ei
In order to fully utilize the technological potential of unconventional superconductors, an enhanced understanding of the superconducting mechanism is necessary. In the best performing superconductors, the cuprates, superconductivity is intimately linked with magnetism, although the details of this coupling remain elusive. Here, we address this gap by studying the electron-doped cuprate Nd1.85Ce0.
Increased soil organic carbon (SOC) sequestration reduces atmospheric CO2 and builds soil health. A conversion from annual crops to perennial crops may decrease negative environmental impacts and promote desired ecosystem services. Soil carbon credit systems and environmental monitoring require reliable verification of SOC change. Here we report a baseline survey of SOC for an agricultural study s
The sensitivity of Ramsey interferometry experiments is governed by the interplay between the beam phase-space distribution and the magnetic field environment through which the spins propagate. Quantitative optimisation thus requires a consistent treatment of optics, magnetics and spin dynamics. We present a simulation framework that enables such an analysis by combining neutron optics simulations
In Sweden, peak-hour travel demand is ranked as the most important operational cost driver for public transport, linked to school and work hours. Achieving a more balanced demand throughout the day is therefore crucial for resource efficiency and promoting environmentally friendly transport. This study aims to gain a deeper understanding of the process of implementing staggered school start times
Ovarian malignancy is the most lethal gynecologic tumor, with an 80% relapse rate and 47% five-year survival. Epithelial ovarian cancer (EOC), the most common form, comprises five major histotypes with distinct clinicopathological characteristics, yet treatment still relies largely on cytoreductive surgery and platinum-based chemotherapy. Phosphoproteomics enables the mapping of protein phosphoryl
