Filetype
This is a proof-of-principle study demonstrating that the combination of a cholera toxin derived adjuvant, CTA1-DD, and lipid nanoparticles (LNP) can significantly improve the immunogenicity and protective capacity of an intranasal vaccine. We explored the self-adjuvanted universal influenza vaccine candidate, CTA1-3M2e-DD (FPM2e), linked to LNPs. We found that the combined vector greatly enhanced
Vaccination of neonates and young infants is hampered by the relative immaturity of their immune systems and the lack of safe and efficacious vaccine adjuvants. Immaturity of the follicular dendritic cells (FDCs), in particular, appears to play a critical role for the inability to stimulate immune responses. Using the CD21mT/mG mouse model we found that at 7 days of life, FDCs exhibited a mature p
BACKGROUND: Sepsis remains a source of high mortality in hospitalized patients despite proper antibiotic approaches. Encouragingly, mesenchymal stromal cells (MSCs) and their produced extracellular vesicles (EVs) have been shown to elicit anti-inflammatory effects in multiple inflammatory conditions including sepsis. However, EVs are generally released from mammalian cells in relatively low amount
Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the liposome-based adjuvants CAF01 and CAF09 and the protein-based adjuvants CTA1-DD and CTA1-3M2e-DD and evaluated whether one or more of the adjuvants c
While numerous extraction methods have been applied to the brown algae Saccharina latissima, a systematic evaluation of how individual extraction parameters influence the extraction of each target polysaccharide has not previously been reported. Accordingly, this study compared conventional and advanced techniques for extracting fucoidan, laminarin, and alginate from pre-treated biomass. Conventio
This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extract; (b) adding the concentrate with an organic solvent which is not mixed with water to separate an organic solvent phase and then co
Disclosed is a process for production of a cycloaliphatic carbonate from a diol, triol or polyol and a carbon dioxide source, such as a dialkyl carbonate. Said process is performed in a solvent-free medium using a N-heterocyclic carbene or N-heterocyclic carbene complex as catalyst. Said N-heterocyclic carbene or carbene complex is preferably attached to a lipase. Said process comprises preferably
Audio Paper offers a conceptual and practice-based approach for researchers across a wide range of disciplines to integrate auditory culture into their published work in the form of the audio paper.The audio paper is an academic text presented as an audio production. Introducing this new format, the book invites scholars to work in a publication format that integrates aesthetic perspectives and te
Recent studies provide compelling evidence that transition dynamics differ between sectors. This paper develops a theoretical framework for analysing the structural composition of a sector and how it shapes transition dynamics. We elaborate a conceptual approach, which emphasizes socio-technical configurations and their degrees of institutionalization and mutual alignment as the key building block
Background: The out-of-plane shear behavior of paperboards plays a critical role in converting processes such as creasing and folding. The recently proposed Split Double Cantilever Beam (SDCB) specimen has been used to characterize this behavior using a cohesive zone model, but its large size poses handling challenges. Objective: This study aims to optimize the SDCB specimen configuration to impro
Adverse childhood experiences (ACEs) can influence physical, cognitive and social development, impacting life outcomes including the child’s capacity to learn and become socially integrated. While steady relations to reliable, understanding adults may enhance child resilience and mitigate long-term effects on well-being, the difficulties of children with ACEs pose a challenge for school personnel.
Purpose: Indications for radiotherapy (RT) of the internal mammary nodes (IMN) in early breast cancer vary between countries. While studies indicate benefits, IMN RT increases the dose to the heart and lungs, and the risk-benefit ratio of this treatment is debated. This study investigates how IMN RT affects dose to organs at risk (OAR) and pneumonitis incidence in a clinical setting. Methods: This
The standard approach for visual place recognition is to use global image descriptors to retrieve the most similar database images for a given query image. The results can then be further improved with re-ranking methods that re-order the top scoring images. However, existing methods focus on re-ranking based on the same image descriptors that were used for the initial retrieval, which we argue pr
The performance of wireless communications at sea are often limited by fading caused by reflections at the sea surface. The reliability could potentially be improved by employing multiple antennas. We have conducted massive multiple-input multiple-output (MIMO) measurements at sea in order to evaluate the performance. The measurements were conducted at 5.6 GHz with 64 dual-polarized antennas, whic
—Capacitor chargers for pulsed power loads are typically realized as two-stage systems consisting of a front-end rectifier and a dclink filter followed by a dc/dc converter. Whereas such systems generally operate in constant current charging mode, it has recently been demonstrated that constant power charging may be achieved and can effectively eliminate line-side flicker. In this article, these i
Nepal has made major progress in expanding its national electricity grid, creating the potential for a double transition as increased access to electricity benefits the energy-poor while setting the infrastructural ground for a transition to renewable energy sources. However, despite increased access, many households in Nepalcontinue to rely on traditional and transition fuels such as firewood and
Objectives: Patients with acute type A aortic dissection (ATAAD) presenting with cerebral malperfusion have significantly poorer postoperative outcomes, making the decision whether to perform acute surgery difficult. The aim of this study was to investigate types of neurological symptoms and radiological findings and their association with permanent neurological injury and mortality following ATAA
Background: Obstetrical anal sphincter injuries are complications of vaginal birth that have the potential to cause substantial maternal morbidity. Predicting these injuries might help to improve maternal care as well as antenatal counseling and patient education. Previous attempts to create prediction models have in many cases involved variables only known postpartum, which limits their use in an
This paper investigates the detection of permittivity defects in a fabricated, known object, motivated by a desire to detect errors in additively manufactured objects that may affect their electromagnetic performance. We use scattering parameter sensitivities to reconstruct the relative permittivity of a generic 2D object from microwave scattering measurements and a known reference model. To find
