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The stringent response is a conserved stress–adaptation program in bacteria, mediated by the alarmones (p)ppGpp that reprogram transcription, translation, and metabolism. This mini–review surveys mechanistic, physiological, and evolutionary facets of alarmone singnaling across two classes of RelA/SpoT homologue (RSH) enzymes: multidomain-containing long RSHs and small alarmone synthetases/hydrolas

Background: The use of high-flow oxygen therapy (HFOT) compared with standard low-flow oxygen therapy (LFOT) may improve outcomes in people with oxygen-dependent chronic respiratory failure (CRF). The primary aim of this multicentre trial was to evaluate HFOT in addition to LFOT, compared with regular LFOT in people with CRF due to chronic obstructive pulmonary disease (COPD) or interstitial lung

Introduction To assess how national income level influences global variation in the diagnosis and management of heart failure with preserved ejection fraction (HFpEF). Methods A web-based survey on HFpEF diagnosis and treatment was distributed worldwide from May to July 2023 through email, scientific societies, and social networks. Respondents provided demographic information and details on diagno

Highlights: What are the main findings? Motor neuron death in TIA1Δ mice occurs prior to detectable TDP-43 phosphorylation. TDP-43 accumulates and mislocalizes in the absence of phosphorylation in TIA1Δ mice, which may represent a speculative pre-aggregation-like disease stage. What are the implications of the main findings? The TIA1Δ mouse model provides a unique tool to dissect early, phosphoryl

Why, despite decades of warnings and solutions, does unsustainable consumption still persist? What keeps societies locked into business as usual even when the consequences are clear? This book contends that part of the answer lies in the myths we adhere to – powerful narratives that normalise the status quo, limit imagination and delay the transition to sustainability. Gathering leading scholars f

The Haro 11 galaxy merger is the closest known Lyman continuum (LyC) leaker and a strong Lyman-α (Lyα) emitter, making it an important analogue of the high-z galaxies that reionised the early Universe. To investigate how Haro 11’s properties arise, we perform a radiation hydrodynamics simulation of the merger, and create mock observations of LyC, Lyα, and Hα, from which we compute their luminositi

Forests are integral to the global carbon cycle, acting as major carbon sinks, though their capacity can be altered by climate and land use changes. India has a diverse forest ecosystem, but the dynamics and changes in its carbon stocks under a changing climate are not well understood. This study investigates the regional and temporal changes in vegetation carbon biomass (VCB) within Indian forest

In the years between 1915 and 1921, Harvard professor of Slavic Languages Leo Wiener (1862–1939) published a controversial and now largely forgotten series of philological studies which sought to prove that that all textual sources testifying to the languages, laws, customs, and beliefs of the ancient Germanic peoples had been forged in the eighth century C.E. by a group of Arabicized Goths in the

Cognitive behavioral therapy (CBT) is a well-established, evidence-based treatment for common mental disorders such as depression, anxiety disorders, and obsessive-compulsive disorder (OCD). However, treatment outcomes vary widely, and a substantial proportion of patients do not achieve sufficient improvement. Robust predictors of individual differences in symptom change are currently lacking. Gen

Background: Cardiovascular risk factor control reduces the risk of recurrent events after acute coronary syndrome (ACS). Long-term post-ACS management is poorly studied. Objectives: To assess frequency of low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP) monitoring and target achievement during 3 years post-ACS. Methods: Data from all patients hospitalized for ACS in Up

Bacteriophages must overcome diverse bacterial immune systems, yet the molecular principles enabling such escape remain poorly understood. Here, we show that the phage homing endonuclease SegB facilitates immune evasion by promoting the segmental amplification of anti-defense loci. The antiphage defense Septu inhibits phage T6 replication by cleaving the variable loop of tRNATyr. We show that SegB

In 2024, the European Academy of Paediatrics (EAP) published a list of 10 low-value practices in paediatric care. Embedded in the Choosing Wisely framework, this list is a step towards promoting targeted and evidence-based care. However, no single recommendation can change prescription habits and we need to acknowledge that overuse of the available resources has multiple causes. Among them, the ph

Software applications can be described using a computational model. These Models of Computation (MoCs) define rules governing application behaviour and properties that are enforced during execution. This thesis focuses on an actor-based MoC, known as dataflow-with-firing, where applications are modelled as actors connected by buffered channels. This model yields a concurrent application descriptio

If asset prices have no jumps it is known that the growth optimal Kelly strategy lies on the local efficient frontier, that is has maximal instantaneous Sharpe ratio. In this paper we show that, when asset prices have jumps, this property ceases to hold. However, the discrepancy is small for jumps with magnitude less than 25%. Our results further indicate that a Kelly trader fears market crashes b

Consolidation of dwellings in self-help settlements is directly dependent on the generation of surplus resources beyond that required for subsistence. A significant proportion of households in such settlements are reliant on income generated within the home for household subsistence as well as to finance the construction of the dwelling itself. There is therefore a close interrelationship between

Sammanfattning Kapitel 2 Presentation av ett nytt tumör-behandlingskoncept med ”Pre-kirurgisk intermittent ultrahypofraktionerad strålbehandling” (PSiRT) ”kombinerad med immunterapi” (PSiRIT), särskilt immun¬kontrollpunktshämmare (anti-CTLA4 och anti-PD-1).Intermittent ultrahypofraktionerad strålbehandling innebär:• Optimal absorberad dos 6–8 Gy per fraktion • Doser >10 Gy kan öka immunosuppressiv