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Objective: Evaluate the impact of adrenalectomy on metabolic parameters and quality of life (QoL) in patients with mild autonomous cortisol secretion (MACS). Method: A multicenter prospective randomized clinical trial compared adrenalectomy with conservative management. Metabolic parameters and QoL were assessed at baseline and after 2 years. Results: Forty-three MACS patients with a single adrena

This paper explores the framework of fractal calculus and its application to classical and quantum field theories. We begin with a brief overview of the fundamental concepts of fractal calculus. Building on this foundation, we introduce the formulation of the classical scalar field within a fractal space. The study is then extended to the quantization of the fractal field, where we examine how fra

This research focuses on developing an integrated flow rate sensor for microfluidic systems, widely used in medical and chemical applications. Unlike commercial sensors that should be attached externally, this sensor is embedded directly on the chip, saving space and improving low-flow measurement accuracy. For chemical experiment use, glass substrates were used for the microfluidic channel. In ad

Since the invention of the laser, nonlinear effects such as filamentation1, Rabi cycling2,3 and collective emission4 have been explored in the optical regime, leading to a wide range of scientific and industrial applications5, 6, 7–8. X-ray free-electron lasers (XFELs) have extended many optical techniques to X-rays for their advantages of ångström-scale spatial resolution and elemental specificit

This research investigates the relationship between trade credit financing and firms’ financial distress using a sample of Chinese listed companies from 2000 to 2020. Our results reveal a significant U-shaped relationship between firms’ trade credit financing and the likelihood of financial distress and that social trust moderates this curvilinear relationship. Our evidence suggests that firm liqu

This paper will discuss the memory-political narrative of the Tower of David Museum, located in the Old City of Jerusalem/al Quds. As part of a current research project on the role of urban imageries and spaces in constructions of Middle Eastern nationalisms, it will explore how the museum is part and parcel of the interwoven historiographic, cultural, and political quest to normalise and obscure

Forskningen om standardisering, automatisering och digitalisering av socialtjänstens handläggningsprocesser belyser ofta att tillhörande tidskrävande dokumentations- och administrationsbörda har betydelse för de välfärdsprofessionellas handlingsutrymme, men landar i olika slutsatser om huruvida detta minskar, förändras eller till och med ökar. I den här presentationen ägnar vi uppmärksamhet åt dig

Purpose: Medical imaging is crucial in modern radiotherapy, aiding diagnosis, treatment planning, and monitoring. The development of synthetic imaging techniques, particularly synthetic computed tomography (sCT), continues to attract interest in radiotherapy. The SynthRAD2025 dataset and the accompanying SynthRAD2025 Grand Challenge aim to stimulate advancements in synthetic CT generation algorith

Work and working conditions are fundamental social determinants of health. Climate change poses an urgent and growing threat to workers' health, through both direct exposure to environmental hazards and indirect exacerbation of social and health inequalities. Occupational health, which focusses on the promotion of mental and physical health and well-being of workers, is a key but often overlooked

An inventory of Viola epipsila has been performed in Skåne, southern Sweden. To elucidate identity of the species and the hybrid with V. palustris, herbarium material was critically examined, including analysis of pollen fertility. Study of papillae (glass hairs) on the lower leaf surface showed an increase of the papilla density during the succession of the leaves (tertiary leaves having more pap

The adsorption of soft microgels at interfaces is a key phenomenon in numerous applications, including emulsification, interfacial stabilization, and responsive coatings. In this work, we employ a combination of in situ atomic force microscopy and numerical simulations to systematically investigate the structural behavior of individual microgels at liquid-liquid and solid-liquid interfaces. By dir

Aims With a growing population of women with congenital heart disease (CHD), pregnancies in this group are expected to increase. However, pregnancy in women with CHD is associated with increased adverse outcomes for both mother and child. The aim of this study was to evaluate pregnancy and foetal complications in women with CHD and to test their association with the modified WHO (mWHO) classificat

INTRODUCTION: Cognitive resilience refers to maintaining cognitive function despite Alzheimer's disease (AD) pathophysiology. METHODS: We analyzed amyloid-positive individuals across clinical stages of AD in two cohorts: the Amsterdam Dementia Cohort (ADC, N = 1036) and Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 685). Cognitive resilience was conceptualized from a canonical correlation

In Singapore, children’s education is typically presented as “an overriding and all-consuming concern,” fueled by extreme competition for grades and school admissions (Waters 2015: 290). However, parents' desire for academic excellence as a route to better lives is not as straightforward as it may seem. Drawing on ethnographic fieldwork with Singaporean families, this paper explores parents' gende

Mental health assessments increasingly rely on remote formats that produce rich but complex multimodal data in the form of text, audio, and video, processed through multiple machine learning models. While these environments offer new opportunities for insight, they also pose significant challenges for effective clinical sensemaking. This study introduces a dashboard designed to address these chall

Background: Lung cancer screening excludes individuals not considered at an increased risk for lung cancer, as predicted by risk models like the Liverpool Lung Project version 3 (LLPv3). In this study, we sought to validate whether plasma glycosaminoglycan profiles (GAGomes) could predict lung cancer independent of LLPv3 and other prespecified comorbidities. Methods: In this retrospective cohort-b

Background Breast cancer is the most frequently diagnosed cancer in women. Survival is generally considered favourable, yet some patients remain at risk of early death. We aimed to assess whether comprehensive whole-genome sequencing (WGS) linked to mortality data could add prognostic value to existing clinical measures and identify patients who might respond to targeted therapeutics. Methods In t

Aim: Clinical trial data have demonstrated that direct oral anticoagulants (DOACs) are both noninferior to and safer than conventional therapy for the treatment of venous thromboembolism (VTE). This study aimed to compare the effectiveness and safety of DOACs versus warfarin using Nordic population-based registries. Materials & methods: This observational cohort study used Swedish, Norwegian a

Particulate methane monooxygenase (pMMO) is an enzyme that converts methane into methanol at ambient temperature and pressure. Over the past three decades, the metal content and location of the active site have been highly controversial. Recent single-particle cryogenic electron-microscopy (cryo-EM) structures have furthered this debate. In this study, three cryo-EM structures (PDB entries 7s4h, 7

Plasma phosphorylated tau (p-tau) biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network d