Search results

Filter

Filetype

Your search for "*" yielded 542616 hits

Sexually antagonistic coevolution between the sex chromosomes of Drosophila melanogaster

Antagonistic interactions between the sexes are important drivers of evolutionary divergence. Interlocus sexual conflict is generally described as a conflict between alleles at two interacting loci whose identity and genomic location are arbitrary, but with opposite fitness effects in each sex. We build on previous theory by suggesting that when loci under interlocus sexual conflict are located on

Tissue folding at the organ–meristem boundary results in nuclear compression and chromatin compaction

Artificial mechanical perturbations affect chromatin in animal cells in culture. Whether this is also relevant to growing tissues in living organisms remains debated. In plants, aerial organ emergence occurs through localized outgrowth at the periphery of the shoot apical meristem, which also contains a stem cell niche. Interestingly, organ outgrowth has been proposed to generate compression in th

A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control

We have analyzed the link between the gene regulation and growth during the early stages of flower development in Arabidopsis. Starting from time-lapse images, we generated a 4D atlas of early flower development, including cell lineage, cellular growth rates, and the expression patterns of regulatory genes. This information was introduced in MorphoNet, a web-based platform. Using computational mod

A global environmental crisis 42,000 years ago

Geological archives record multiple reversals of Earth’s magnetic poles, but the global impacts of these events, if any, remain unclear. Uncertain radiocarbon calibration has limited investigation of the potential effects of the last major magnetic inversion, known as the Laschamps Excursion [41 to 42 thousand years ago (ka)]. We use ancient New Zealand kauri trees (Agathis australis) to develop a

“Beyond the Prison Gate”: Exploring Recognition through Photography with Former Political Prisoners in Myanmar

This article argues that imprisonment is a liminal experience and that recognitionis needed to establish a new social status to enable parity of participation afterone’s release. The article builds on photographic action research done with fourformer political prisoners in Myanmar, and analyzes three of the photos from theproject and the process of creating and exhibiting photos. The article shows

A 60 GHz receiver front-end with PLL based phase controlled LO generation for phased-arrays

This paper presents a fully integrated 60 GHz frontend for phased array receivers. For the first time in the literature a phase controlled phased locked loop (PC-PLL) is used for beamforming at 60 GHz. The front-end performs a two stage frequency down-conversion, first from 60 GHz to 20 GHz, then from 20 GHz to quadrature baseband. Both the local oscillator signals at 20 GHz and 40 GHz are generat

Integrated Solutions for Daylighting and Electric Lighting : IEA SHC Task 61/EBC Annex 77, Subtask D - Proposal and First Results

The integration of daylight and electric lighting, considering user satisfaction and energy savings potentially can contribute significantly to reduce energy demand for lighting, that represents 18% of global energy demands. This paper presents the work and first results of IEA SHC Task 61/EBC Annex 77 “Integrated Solutions for Daylighting and Electric Lighting: From component to user centered sys

The MafA-target gene PPP1R1A regulates GLP1R-mediated amplification of glucose-stimulated insulin secretion in β-cells

The amplification of glucose-stimulated insulin secretion (GSIS) through incretin signaling is critical for maintaining physiological glucose levels. Incretins, like glucagon-like peptide 1 (GLP1), are a target of type 2 diabetes drugs aiming to enhance insulin secretion. Here we show that the protein phosphatase 1 inhibitor protein 1A (PPP1R1A), is expressed in β-cells and that its expression is

A pebble accretion model for the formation of the terrestrial planets in the solar system

Pebbles of millimeter sizes are abundant in protoplanetary discs around young stars. Chondrules inside primitive meteorites - formed by melting of dust aggregate pebbles or in impacts between planetesimals - have similar sizes. The role of pebble accretion for terrestrial planet formation is nevertheless unclear. Here, we present a model where inward-drifting pebbles feed the growth of terrestrial

Accumulation of cellular prion protein within β-amyloid oligomer plaques in aged human brains

Alzheimer's disease (AD) is the main cause of dementia, and β-amyloid (Aβ) is a central factor in the initiation and progression of the disease. Different forms of Aβ have been identified as monomers, oligomers, and amyloid fibrils. Many proteins have been implicated as putative receptors of respective forms of Aβ. Distinct forms of Aβ oligomers are considered to be neurotoxic species that trigger

Controlled generation of luminescent centers in hexagonal boron nitride by irradiation engineering

Luminescent centers in the two-dimensional material hexagonal boron nitride have the potential to enable quantum applications at room temperature. To be used for applications, it is crucial to generate these centers in a controlled manner and to identify their microscopic nature. Here, we present a method inspired by irradiation engineering with oxygen atoms. We systematically explore the influenc

Shore crabs reveal novel evolutionary attributes of the mushroom body

Neural organization of mushroom bodies is largely consistent across insects, whereas the ancestral ground pattern diverges broadly across crustacean lineages resulting in successive loss of columns and the acquisition of domed centers retaining ancestral Hebbian-like networks and aminergic connections. We demonstrate here a major departure from this evolutionary trend in Brachyura, the most recent

Salbutamol for transient tachypnea of the newborn

BACKGROUND: Transient tachypnea of the newborn is characterized by tachypnea and signs of respiratory distress. Transient tachypnea typically appears within the first two hours of life in term and late preterm newborns. Although transient tachypnea of the newborn is usually a self-limited condition, it is associated with wheezing syndromes in late childhood. The rationale for the use of salbutamol