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Apathy and affective symptoms associated with elevated plasma neurofilament light but not p-tau181 in Alzheimer's disease

INTRODUCTION: Apathy and affective neuropsychiatric symptoms (NPS) are prevalent in Alzheimer's disease (AD), yet their neurobiological cause is still unclear. We examined associations between plasma neurofilament light chain (NfL) and tau pathology (p-tau181) with apathy and affective symptoms in mild cognitive impairment (MCI) and AD dementia. METHODS: This longitudinal study analyzed data from

Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope : A Randomized Sham-Controlled Trial

Background: Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear. Objectives: This study sought to compare the effectiveness of lower extremity compression with thigh-high ECS vs sham stockings for the prevention of VVS recurr

The heterogeneity of type 1 diabetes : implications for pathogenesis, prevention, and treatment - 2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum

This article summarises the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organised by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified and, nota

Do the varying drying rates influence rhinovirus infectivity?

Objective: Human rhinovirus is the most common cause of the common cold worldwide (1). It has been shown that a substantial part of the airborne viruses is found in aerosol particles in the range of 1-4 µm (2). Studying the infectivity of aerosol particles in this range is, however, challenging; therefore, not many studies have been conducted on their infectivity. The aim of this work is to invest

Tilläggsskatterapporten och betalning av tilläggsskatt – nya rättsliga utmaningar

I artikeln analyseras förfarandereglerna i den svenska tilläggsskattelagstiftningen och deras förenlighet med unionsrätten och Europakonventionen. Fokus ligger på aspekter kopplade till rapportering, sanktionsavgifter och potentiellt oskäliga skatteuttag. Särskild uppmärksamhet ägnas åt frågan om den förenklade tilläggsskatterapportens rättsliga status, risken för dubbelbestraffning i strid med ne

From Social Hubs to Silent Shops: The Impact of Unmanned Stores on Rural Community Life

This study explores how the emergence of unmanned stores impacts the sense of community in rural areas. It is set against the backdrop of increased urbanization, which threatens the survival of smaller rural communities. We study this through ethnographic inquiry into the emergence of unmanned stores. These have been introduced to counteract the depopulation of rural areas. We identify four ways i

Bystander behavior in workplace bullying : a vignette study exploring how organizational space and situational strength influence intentions to intervene

Purpose: The study explores how organizational space and situational strength influence bystanders’ intentions to intervene in workplace bullying within the healthcare sector. Design/methodology/approach: The research employs vignette-based interviews with 24 healthcare professionals from various medical fields in Sweden. The vignettes depict different bullying scenarios occurring in various spati

Förutsättningar för hållbara samverkansprojekt inom offentlig sektor - En intervjustudie om brottsförebyggande utvecklingsarbete i Lunds kommun

This thesis explores the conditions and factors necessary for achieving sustainability and generating long term effects from collaborative projects in the public sector. Accordingly, this paper will examine a pilot crime prevention project in Lund municipality and investigate its conditions and resources to attain sustainable organizational structures. The paper is conducted in collaboration with

Rediscovering uncertainty in social work : The case of anonymous text-based encounters online

Uncertainty has long been discussed in social work as an inherent element of professional practice. The present paper extends this discussion into the realm of digital social work. It reports a study of anonymous text-based online counselling provided by the social services in Sweden. We explore what kind of uncertainty is evoked when social workers respond to anonymous users through online platfo

Historical manufacturing census of Sweden: Data description and quality assessment

This article presents a comprehensive database featuring the digitized, cleaned, geocoded, and linked data of the Swedish manufacturing censuses between 1863 and 1900. The data covers close to the universe of Swedish manufacturing activity and includes establishment-level information on workers, the sum of production value, and toll as output value. The article describes how the data was originall

A multi-scaling approach showing a transient metabolic mismatch in a freshwater fish (Zingel asper) during an acute heat stress

Heat stress events will be more frequent and intense in the future. These events will challenge the capacity of organisms to exhibit sufficient metabolic flexibility to adapt to such variations. To better understand the acclimation processes implemented in response to acute warming, with an integrative approach we examined in vivo metabolic rate and cardiac mitochondrial respiration in the Rhône s

What Happened to the Incomes of the Rich during the Great Levelling? Evidence from Swedish Individual-Level Data, 1909–1950

We use individual-level income data from archived taxation lists to study top-income earners in Sweden from 1909 to 1950. Using information on 21,055 individual taxpayers in two elite areas in greater Stockholm, we show that top incomes fell in real terms over this period, at a stable pace without obvious connection to the Great Depression or the world wars. The peak of inequality was related to tWe use individual-level income data from archived taxation lists to study top-income earners in Sweden from 1909 to 1950. Using information on 21,055 individual taxpayers in two elite areas in greater Stockholm, we show that top incomes fell in real terms over this period, at a stable pace without obvious connection to the Great Depression or the world wars. The peak of inequality was related to t

Integrative taxonomy, phylogeny and distribution patterns of the diverse Neotropical cloud forest butterfly genus Perisama Doubleday (Nymphalidae, Biblidinae, Callicorini)

Phylogenetic relationships of the predominantly Andean species-rich nymphalid genus Perisama are explored based on five genetic markers and a total of 3719 bps, and morphological characters of the adults with an emphasis on male genitalia and wing colour patterns. Its monophyly is recovered by including the genera Orophila, which turns out polyphyletic, and Mesotaenia. Two main, highly supported c