Drug-resistant neuroblastoma remains a major challenge in paediatric oncology and novel and less toxic therapeutic approaches are urgently needed to improve survival and reduce the side effects of traditional therapeutic interventions. Mesenchymal stem cells (MSCs) are an attractive candidate for cell and gene therapy since they are recruited by and able to infiltrate tumours. This feature has bee

PURPOSE: Early metabolic response with a decrease in glucose demand after cytotoxic treatment has been reported to precede tumor volume shrinkage. However, preclinical studies report of a very early rise in metabolism, a flare, following treatment. To elucidate these observations, we performed an experimental study on early metabolic response with sequential analysis of metabolic changes. METHODS:

The present invention relates to a method of extg. 3-​hydroxypropionaldehyde (3-​HPA) and​/or derivs. thereof from an aq. soln. comprising 3-​HPA. This method comprises (a) contacting the aq. soln. comprising 3-​HPA with chitosan and​/or chitosan comprising polymers, (b) sepg. the 3-​HPA bound chitosan and​/or chitosan comprising polymers, and (c) washing the 3-​HPA bound chitosan and​/or chitosan

Ever since its introduction 40 years ago l-3,4-dihydroxyphenylalanine (l-DOPA) therapy has retained its role as the leading standard medication for patients with Parkinson's disease. With time, however, the shortcomings of oral l-DOPA treatment have become apparent, particularly the motor fluctuations and troublesome dyskinetic side effects. These side effects, which are caused by the excessive sw

We are constantly exposed to infectious diseases, and they cause millions of deaths per year. TheWorld Health Organization (WHO) estimates that antibiotic resistance could cause 10 million deaths per year by 2050. Multidrug-resistant bacteria are the cause of infection in at least one in three people suffering from septicemia. While antibiotics are powerful agents against infectious diseases, the

Objectives: We conducted a large cohort study to investigate the association between work-related wrist movements and carpal tunnel syndrome (CTS). Methods: Electro-goniometric measurements of wrist movements were performed for 30 jobs (eg, office work, child care, laundry work and slaughterhouse work). We measured wrist angular velocity, mean power frequency (MPF) and range of motion (ROM). We es

Reliable wireless communication links are a critical but challenging aspect for high-speed railway (HSR). To develop and analyze such systems, accurate models for the propagation channel are required. The radio channel properties in HSR scenarios are different from those in cellular scenarios not only due to the high velocity, but also due to the special construction elements and the type of surro