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Introduction: The Elekta Synergy machine for external beam radiation therapy is equipped with an x-ray tube for on-line kV imaging and correction of the patient setup. The system can provide both 2D and 3D data for image guided radiotherapy (IGRT). Different aspects of the imaging system (called XVI) has been evaluated, such as image quality, flex of the gantry rotation, accuracy for patient setup
Magnetresonans, förkortat MR, är ett fysikaliskt fenomen som tillämpas inom medicinsk diagnostik för bildtagning. Med hjälp av mycket starka magnetfält kan bilder erhållas, exempelvis på hjärnan, utan att joniserande strålning används. Förutom bilder kan MR-bildtagning även användas för att avbilda perfusion (kapillärblodflöde) och vattendiffusion i hjärnan. Ytterligare ett användningsområde är av
The purpose with this work has been to develop and construct a Niobium target for the production of [18F]fluoride with a MC 16 Scanditronix cyclotron. The future demand larger amounts of [18F]fluoride and to satisfy the forthcoming needs an enhanced target needs to be installed on the cyclotron. The old target could have provided the forthcoming needs but to obtain good margins it is important wit
Med röntgenstrålning går det i dagsläget att avbilda kroppens inre anatomi i antingen två eller tre dimensioner. Vid en vanlig slätröntgenundersökning (2D) tas en så kallad projektionsbild från en eller två vinklar, framifrån/bakifrån och från sidan. Detta genererar en tvådimensionell bild där alla (anatomiska) strukturer mellan röntgenröret och filmen överlagras, d.v.s. de går inte att separera fDuring the last century several attempts have been made to overcome the fundamental problem of X-ray imaging, i.e. that anatomical information existing in 3-dimensions has to be represented on a 2-dimensional radiograph. In this thesis, digital tomosynthesis, a rened version of conventional tomography, has been investigated. Digital tomosynthesisenables retrospective reconstruction of an arbitrary
Quantification in Nuclear Medicine Imaging is highly desirable for a number of reasons. In Targeted Radionuclide Therapy for example, accurate estimation of the absorbed dose delivered to the patient depends upon accurately quantified images. In Tracer Kinetic Studies quantification is also required in order to obtain accurate biodistribution data. One of the major problems connected with Nuclear
Background: To gain more knowledge of the mechanism behind the appearance of radiation induced cancer, the cellular response at low doses has to be studied. A Single Ion Hit Facility (SIHF) at the Lund Nuclear Microprobe Laboratory will be used for this purpose. The facility allows single MeV ions to hit single living cells.Purpose: The goals of this work were to i) design a suitable cell dish whe
Strålning kan medföra både skada och nytta. Inom strålbehandling utnyttjas strålningen för att bota eller lindra cancersjukdomar. Målet är att med hjälp av joniserande strålning slå ut alla tumörceller samtidigt som man försöker skona övriga friska celler. Strålningen som produceras i den vanligaste utrustningen för extern strålbehandling, nämligen linjäraccelerator, är elektronstrålning och fotonPurpose: Medical linear accelerators that operate above 10 MeV produce neutrons by photonuclear reactions which present a potential radiation hazard to the personnel. The purpose of this study was to estimate neutron dose contributions to the personnel working with external radiotherapy at Malmö University Hospital (UMAS), compare different kind of neutron detectors/dosimeters, and evaluate how to
Introduction: The main route of excretion of activity for most administered radiopharmaceuticals is via the urinary bladder and it is important to estimate the absorbed dose to the mucosal surface of the bladder wall, especially when radiopharmaceuticals are given for therapeutic purposes. The purpose of this thesis was to investigate how the absorbed dose varies with changes in the parameters, wh
Hals- och huvudregionen innehåller många luftkaviteter t.ex. luftstrupe, bihålor och munhåla. Detta arbete undersökte vad som händer i vävnaden kring dessa luftkaviteter när de blir bestrålade med fotoner och hur bra ett dosplaneringssystem för strålbehandling modellerar den absorberade dosen till ett heterogent medium. Dosberäkningarna gjordes med hjälp av ett Monte Carlo-simuleringsprogram somPurpose: To study the build-down and build up of the absorbed dose at the interface between air and tissue in the head and neck region. Monte Carlo simulations are compared to a treatment planning system that is used at the University Hospital in Lund. Materials and methods A virtual phantom was constructed to resemble an air cavity in the head and neck region. The phantom consisted of a water cyl
Varje år får cirka 50 000 svenskar diagnosen cancer. Mot detta är strålbehandling en vanlig behandlingsmetod och det uppskattas att cirka en tredjedel av alla som får cancer någon gång under sin behandling får strålbehandling. En viktig sak inom strålbehandling är att patienten får den dos som läkaren har ordinerat. Detta är en så vital detalj inom strålbehandling att SSI, Statens StrålskyddsinsIndependent dose calculations in radiotherapy are important as they help assure that the dose given to the patient is the same as the prescribed. The current version of software Radiation Verification Programme, RVP, does not take into account the effects that occur when a beam from a linear accelerator is moved off-axis. The aim with this project was to find a model for these effects, fit the par
Kvaliteten på kliniska bilder har stor betydelse för korrekt medicinsk diagnostik. I konventionella morfologiska MR-bilder är signalen normalt relativt hög i förhållande till bruset. Vissa nya MR-metoder för s.k. funktionsdiagnostik bygger emellertid på en avsiktlig degradering av signalen för att vissa kvantitativa parametrar skall kunna beräknas. I sådana studier kan följaktligen signal-till-bruNoise is a well-known problem in many imaging modalities. In magnitude magnetic resonance images, obtained by quadrature detection, the associated Rician distribution of noise constitutes a further complication. This type of noise is especially problematic at low signal-to-noise ratio (SNR) regions. The Rician noise distribution causes a non-zero minimum signal in the image, often referred to as t
Determination of absolute activity of 99mTc and 123I in organs for the purpose of patient-specific dosimetry in nuclear medicine examinations and therapy is of great importance. In order to make accurate quantification of the organ content from planar gamma camera images of phantoms, several corrections has to be made. The accuracy of a number of correction methods and different combinations of th
Introduction: To our knowledge a biomedical model for validation of combined MicroPET/MicroCAT studies of the thyroid with 124I has not yet been developed. Such an in vivo physiological rat model could be of great interest for enhancing the possibilities of studying common thyroid diseases realistically and repeatedly. Furthermore, a well developed, realistic, and flexible model can also be of gre
This work shows a contribution to a long-term study of lead in smelter workers where the objectives were to assess the historical lead (Pb) exposure and to study the relationships between lead concentrations in finger bone (Bone-Pb), whole blood (B-Pb), plasma (P-Pb), urine (U-Pb) and the duration of employment in workers at a secondary lead smelter. Moreover, results were compared with previous s
Syftet med denna studie var att utvärdera säkerhetsmarginalerna som läggs kring ett målorgan (tex prostata) vid extern strålterapi. Resultaten kan senare ligga till grund för reducering av säkerhetsmarginalerna, detta för att skydda strål-känslig frisk vävnad från onödig bestrålning. En delstudie var också att försöka finna ett mönster hos prostatans rörelse vid de inledande behandlingstillfällena"Introduction: This thesis is a study of the margins that are necessary in prostate cancer radio therapy treatment. The aim was to analyse the intrafraction motion of the prostate gland during treatment, by the use of portal imaging, in order to optimize the margin around the prostate gland and spare healthy tissue. One of the purposes was to find a common pattern in prostate movement in the
Purpose: To study Intensity Modulated Proton Therapy (IMPT) with a new treatment planning optimization software. The aim was also to make a comparative study between existing conventional photon plans, Intensity Modulated X-ray Therapy (IMXT) plans and IMPT plans for three different cancer diagnoses. Materials and methods: The conventional photon plans and the IMXT plans were optimized in Oncentra
Functional Magnetic Resonance Imaging, fMRI, is a non invasive method to map brain activation with a magnetic resonance camera. In this thesis we propose a method to deal with motion induced artefacts in functional fMRI, using Independent Component Analysis, ICA. Patient movement can induce false activation or cause loss of true activation. Movement is one of the most common causes of fMRI failure
The Monte Carlo method has become increasingly used to simulate imaging systems like the scintillation camera and SPECT systems. In order to investigate intrinsic properties of SPECT systems the Monte Carlo based application SIMIND (Simulating Medical Imaging Nuclear Detectors) has been developed. Up to now, it has not been able to simulate a pinhole-imaging device with SIMND. The aim of this work
Vattenmolekyler är i ständig slumpmässig rörelse som beror på systemets termisk energi, dvs temperaturen. Diffusionsrörelsen kallas även Brownsk rörelse efter den engelske botanikerns Brown, som upptäckte fenomenet på 1800 talet. Människokroppen består till 70 % av vatten, vilket gör det lämpligt att använda MRT för att studera diffusionsegenskaper i biologisk vävnad och för klinisk diagnostik av Magnetic resonance imaging (MRI) is still a fast growing area of research and is an important part of the clinical tools used for diagnosis of various diseases. The diagnostic values of diffusion imaging are well known especially for ischemic stroke in the acute phase. This work concerns whether the apparent diffusion coefficient (ADC) and the full width at half maximum (FWHM) changes when the ima
Small-animal positron emission tomography (PET) has proven to be a promising and useful modality for preclinical pharmacokinetic studies. Thanks to high sensitivity and spatial resolution in the range of a few millimetres, the possibility to perform reliable and accurate quantification and absorbed dose estimates is within reach. In preclinical radioimmunotherapy (RIT), the slow targeting and clea
