Maturity Onset Diabetes of the Young (MODY) is a young-onset, monogenic form of diabetes without needing insulin treatment. Diagnostic testing is expensive. To aid decisions on who to test, we aimed to develop a MODY probability calculator for paediatric cases at the time of diabetes diagnosis, when the existing “MODY calculator” cannot be used. Firth logistic regression models were developed on d

The nature of work has already, for some time, been undergoing major changes as a result of technological progress. Mobile, virtual and cloud technologies, and the infrastructures that support them, are increasingly enabling work to be done from anywhere and at any time. The COVID-19 pandemic has further accelerated this process, driving a large share of white-collar knowledge work to remote and h

This study examines the impact of the extensive climatic and environmental changes associated with the Early Holocene on the feeding ecology of aurochs, European bison, red deer, and Eurasian elk in southern Scandinavia from radiocarbon dates and analysis of stable carbon and nitrogen isotopes. Molecular sex information is utilised in the study of aurochs to understand the underlying reasons behinThis study examines the impact of the extensive climatic and environmental changes associated with the Early Holocene on the feeding ecology of aurochs, European bison, red deer, and Eurasian elk in southern Scandinavia from radiocarbon dates and analysis of stable carbon and nitrogen isotopes. Molecular sex information is utilised in the study of aurochs to understand the underlying reasons behin

BackgroundSwift identification and diagnosis of gastrointestinal infections are crucial for prompt treatment, prevention of complications, and reduction of the risk of hospital transmission. The radiological appearance on computed tomography could potentially provide important clues to the etiology of gastrointestinal infections. We aimed to describe features based on computed tomography of patien

Carpal tunnel syndrome (CTS) occurs more often among individuals with diabetes. The aim of this retrospective observational registry study was to examine whether individuals with diabetes and CTS are treated surgically to the same extent as individuals with CTS but without diabetes. Data on CTS diagnosis and surgery were collected from the Skåne Healthcare Register (SHR). A total of 35,105 individ

Objective. To explore how the perceptions and experiences of working with risky drinkers change over time among primary health care staff during a systematic implementation project. Methods. Qualitative focus group interviews took place before and after the implementation of the project. Results. The staff displayed a positive change during the implementation period with regard to awareness, knowl

AIM: To compare two identification methods for risky drinking in primary health care centres (PHCs).METHODS: Sixteen PHCs from three Swedish counties were randomized into strands: consultation-based early identification (CEI) or systematic screening early identification (SS). Measurements took place at baseline and during two intervention periods. Patients filled in questionnaires including gender

AIMS: To review the literature on detection of risky drinking to compare early identification based on everyday clinical encounters with systematic screening. We also reviewed specific clinical signs that have been suggested to be used as indicators of risky drinking.METHODS: A literature review was performed in PubMed and CINAHL of articles up to November 2010.RESULTS: Systematic screening and se

Fetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by the placenta. The objective of this systematic review was to summarize and critically evaluate publications describing associations between human placental changes and risk of atopic disorders during childhood. The review adhered to the Preferred Reporting Items for Systemati

Bergweiler and Kotus gave sharp upper bounds for the Hausdorff dimension of the escaping set of a meromorphic function in the Eremenko–Lyubich class, in terms of the order of the function and the maximal multiplicity of the poles. We show that these bounds are also sharp in the Speiser class. We apply this method also to construct meromorphic functions in the Speiser class with preassigned dimensi

Quantum thermal machines can generate steady-state entanglement by harvesting spontaneous interactions with local environments. However, using minimal resources and control, the entanglement is typically weak. Here, we study entanglement generation in a two-qubit quantum thermal machine in the presence of a continuous feedback protocol. Each qubit is measured continuously and the outcomes are used

AimThe risk of mesh-related surgical complications after umbilical hernia repair is not known and chronic pain has only sparsely been analysed. Economic claims may represent a surrogate for poor postoperative surgical outcomes. Thus, the present study used mesh-related complications and chronic pain as primary and secondary outcomes, respectively.Material and MethodsBlinded assessment of Swedish a

Vapor transport in porous media, often associated with liquid-vapor phase change, is an fundamental process in many emerging underground energy storage and extraction processes (i.e., seasonal solar thermal aquifer storage, geothermal extraction, extraterrestrial in-situ water extraction). By jointly using experimental imaging and numerical modeling at the micro-scale, we conduct mechanistic pore

Dialogue and engaging with the religious Other are essential questions that warrant even greater attention in the Christian communities at large. In 2020, the World Council of Churches and the Pontifical Council for Interreligious Dialogue jointly published a document on interreligious solidarity titled Serving a Wounded World in Interreligious Solidarity: A Christian Call to Reflection and Action

Amyloid fibrils have been implicated in the pathogenesis of several neurodegenerative diseases, the most prevalent example being Alzheimer's disease (AD). Despite the prevalence of AD, relatively little is known about the structure of the associated amyloid fibrils. This has motivated our studies of fibril structures, extended here to the familial Arctic mutant of Aβ1-42, E22G-Aβ1-42. We found E22

Several stars show deep transits consistent with discs of roughly seen at moderate inclinations, likely surrounding planets on eccentric orbits. We show that this configuration arises naturally as a result of planet-planet scattering when the planets possess satellite systems. Planet-planet scattering explains the orbital eccentricities of the discs' host bodies, while the close encounters during

In the context of a decarbonized future where stringent carbon dioxide (CO2) emissions constraints are imposed on vehicles, hydrogen emerges as a promising solution to address emissions directly at the point of use. This chapter explores the potential of using hydrogen to power vehicles, particularly in the context of heavy-duty (HD) internal combustion engine (ICE) applications. Hydrogen vehicles