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Article 17 DSM Directive: the Swedish proposal (Part 1)

Commentary and analysis of the proposal of the Swedish Ministry of Justice (Ds 2021:30) concerning implementation of Article 17 Directive 2019/790 on copyright and related rights in the Digital Single Market (DSM Directive). Part 1 of 2.

An individual participant data meta-analysis of breast cancer detection and recall rates for digital breast tomosynthesis versus digital mammography population screening

Background: Although digital breast tomosynthesis (DBT) improves breast cancer screen-detection compared to digital mammography (DM), there is less evidence on comparative screening outcomes by age and breast density, and inconsistent evidence on its effect on recall rate. Method: We performed an individual participant data (IPD) meta-analysis from DBT screening studies (identified to November, 30

Outbreak of occupational allergic contact dermatitis from a smartphone screen protector glue

Background: Sensitization to acrylates is a concern in the occupational/environmental dermatology field. Objective: To describe an occupational allergic contact dermatitis (ACD) outbreak from a smartphone screen protector glue. Methods: Thirteen affected workers of a chain store selling phone screen protectors were investigated in five Spanish dermatology departments. The glue datasheet and label

Artificial Intelligence Evaluation of 122 969 Mammography Examinations from a Population-based Screening Program

Background Artificial intelligence (AI) has shown promising results for cancer detection with mammographic screening. However, evidence related to the use of AI in real screening settings remain sparse. Purpose To compare the performance of a commercially available AI system with routine, independent double reading with consensus as performed in a population-based screening program. Furthermore, t

Crisis and Public Support for the Euro, 1999–2014

This contribution analyses the evolution of public support for the single European currency, the euro, from 1990 to 2014 for a 12-country sample of the euro area (EA-12), focusing on the most recent period of the financial and sovereign debt crisis, starting in 2008. We find that citizens’ support for the euro on average was marginally reduced during the first six years of the crisis, and that sup

Quality of life and resource utilization-Swedish data from the Care of Late-Stage Parkinsonism (CLaSP) study

Background: Few studies have investigated the health-related quality of life (HRQoL), resource use and costs in patients with late-stage Parkinson's disease (PD), and data from the Swedish setting are scarce. Objectives: First, we analyse the HRQoL in late-stage PD in Sweden. Second, we analyse the resource use and costs per severity level. Third, we analyse the relationship between costs and phys

The Enduring Popularity of the Euro throughout the Crisis

This paper analyses the evolution of public support for the euro from 1990 to 2011, using a popularity function approach, focusing on the most recent period of the financial and sovereign debt crisis. Exploring a huge database of close to half a million observations, covering the 12 original euro area member countries, we find that the ongoing crisis has only marginally reduced citizens’ support f

On photovoice—Applications and reflections to an intensive care context

Background: In this paper, we share our experiences of using ‘photovoice’ methodology as a way to generate data in intensive care units concerning the place and space of care. We have adapted and modified ‘photovoice’ in researching people's lived experiences of ICU. Researching lived experiences in an intensive care context is challenging because of the complex nature of critical care. Aim: This

PhosPiR : an automated phosphoproteomic pipeline in R

Large-scale phosphoproteome profiling using mass spectrometry (MS) provides functional insight that is crucial for disease biology and drug discovery. However, extracting biological understanding from these data is an arduous task requiring multiple analysis platforms that are not adapted for automated high-dimensional data analysis. Here, we introduce an integrated pipeline that combines several

Public Support for the Euro

The euro as a common currency has recently been the subject of harsh criticism by economists from both sides of the Atlantic, including claims that citizens in some Eurozone countries are turning against it. This contribution argues that, in fact, the euro currently enjoys comfortable popular support in each of the 12 original member states of the Eurozone and that potential upcoming referenda in

Crisis and Public Support for the Euro

The Eurozone crisis has meant slow growth, rising unemployment and social unrest. This contribution gauges the impact of these negative developments on European citizens’ opinion about the euro and the EU institutions. Using Eurobarometer surveys, the authors find that, within the Eurozone, the crisis has only marginally lowered support for the euro but has led to a sharp fall in public trust in t

Mycorrhizal tree impacts on topsoil biogeochemical properties in tropical forests

In tropical regions, the patterns of carbon (C) and nutrient properties among ecosystems dominated by distinct mycorrhizal associations are unknown. We aim to reveal whether the dynamics differ and the ecological drivers and ecosystem functioning implications of such differences. Based on a dataset of 97 tropical forest sites, we related EcM trees abundance (as a proxy for the transition from AM t

Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein

Dimethyl sulfoxide (DMSO) is a highly utilized small molecule that serves many purposes in scientific research. DMSO offers unique polar, aprotic and amphiphilic features, which makes it an ideal solvent for a wide variety of both polar and nonpolar molecules. Furthermore, DMSO is often used as a cryoprotectant in cell-based research. However, recent reports suggest that DMSO, even at low concentr

Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits

The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the av

Evaluating an internet-delivered fear conditioning and extinction protocol using response times and affective ratings

Pavlovian fear conditioning is widely used to study mechanisms of fear learning, but high-throughput studies are hampered by the labor-intensive nature of examining participants in the lab. To circumvent this bottle-neck, fear conditioning tasks have been developed for remote delivery. Previous studies have examined remotely delivered fear conditioning protocols using expectancy and affective rati

Dual antithrombotic treatment in chronic coronary syndrome : European Society of Cardiology criteria vs. CHADS-P2A2RC score

AIMS: According to the 2019 European Society of Cardiology (ESC) guidelines on chronic coronary syndromes (CCS), adding a P2Y12 inhibitor or rivaroxaban to aspirin should be considered in high-risk patients. We estimated the proportion of patients eligible for treatment with the ESC criteria and examined if a recently validated risk score (CHADS-P2A2RC) could improve risk prediction. METHODS AND R

Experimental determination of k Qfactors for two types of ionization chambers in scanned proton beams

Objective. Experimental determination of beam quality k Q factors for two types of Farmer ionization chambers, NE2571 and IBA FC65-G, in a scanned proton beam for three nominal energies (140 MeV, 180 MeV and 220 MeV) based on water calorimetry. Approach. Beam quality correction factors were determined comparing the results obtained with water calorimetry and ionometry. Water calorimetry was perfor

Oxidation of 5-hydroxymethylfurfural with a novel aryl alcohol oxidase from Mycobacterium sp. MS1601

Bio-based 5-hydroxymethylfurfural (HMF) serves as an important platform for several chemicals, among which 2,5-furan dicarboxylic acid (FDCA) has attracted considerable interest as a monomer for the production of polyethylene furanoate (PEF), a potential alternative for fossil-based polyethylene terephthalate (PET). This study is based on the HMF oxidizing activity shown by Mycobacterium sp. MS 16

Allocation of ecological water rights considering ecological networks in arid watersheds : A framework and case study of Tarim River basin

A robust water supply system is significant to the local ecosystem of riparian vegetation in the arid basin. Considering the elasticity and relative importance of ecological water use in different regions of the basin, this study defines the ecological water rights on a multi-year scale, divides the priority of those rights based on the ecological network, and proposes a rights allocation method.