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Insoluble tau aggregates within neurofibrillary tangles are a defining neuropathological feature of Alzheimer's disease (AD) and closely correlate with clinical symptoms. Although tau pathology can be assessed using tau positron emission tomography, a more accessible biomarker is needed for diagnosis, prognosis and tracking treatment effects. Here we present a new plasma tau species, the endogenou
LTx remains the definitive treatment for end-stage lung disease, but the increasing demand for donor lungs outpaces the available supply. This chapter explores innovative approaches to expand the pool of viable donor lungs and reduce waiting times, which is crucial to lowering mortality rates among patients on transplant lists. Xenotransplantation, which has made its greatest strides using porcine
The field of organ transplantation is experiencing a transformative shift with the rise of Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell therapies, and tissue-engineered products. These therapies offer new, potentially curative treatments for longstanding medical challenges, impacting numerous patients. However, their adoption is hindered by complex regula
As advancements in transplantation techniques continue, the challenge remains the limited availability of suitable donor organs. This chapter explores strategies to expand the donor pool and optimise transplant outcomes, which include the use of extended criteria donors, living lobar transplantation, donor-to-recipient graft size matching, and innovations in hypothermic storage and ex vivo lung pe
Dissolved organic carbon (DOC) affects the acidity in soil and lake waters and buffers both against acidification and against recovery from acidification. Current acidification assessments, based on the widely used MAGIC (Model of Acidification of Groundwater In Catchments) model, often assume constant DOC concentrations through time, but observations suggest this assumption may not be warranted.
Objective. To investigate the course of disability related to the upper extremities (UEs) in early rheumatoid arthritis (RA), and to assess correlations between such disability and clinical variables, including grip force. Methods. In an inception cohort of patients with early RA (diagnosed 1995-2005, N = 222, follow-up 10 yrs), disability of the UEs was assessed using a subscore of the Health Ass
Acute SARS-CoV-2 infections are not always diagnosed; hence an unknown proportion of all infections are not documented. SARS-CoV-2 can induce spike and nucleocapsid protein specific IgG antibodies, which can be detected in seroprevalence studies to identify a previous infection. However, with the introduction of vaccines containing the spike protein it is no longer possible to use spike-IgG as a m
Organ-on-a-chip devices are predominately made of the polymer polymethylsiloxane (PDMS), exhibiting several attractive properties e.g., transparency, gas permeability, and biocompatibility. However, the attachment of cells to this polymer has proven challenging, especially for delicate primary cells e.g., small intestinal organoid-derived epithelial cells. Hence, a need to functionalize and coat t
Impossible colors is not a hypothesis, but rather more hyperbole. In this musical piece "impossible colors" refer to illusions of timbre in sound, not vision.Impossible colors are colors that we do not normally see; that some fictional colors are beyond the functional perceptual space of humans. Some theories looking at forbidden colors, borrowed from color research in vision are applied in this p
To Alan Walmsley, at sixty-fiveJarash (also Jerash, Greek Gerasa) ranks among the principal urban centres of Late Antique and Early Islamic Jordan. Despite being one of the most intensively investigated urban sites within the region, the history of Jarash during the Islamic ages, in particular after the massive earthquake of 749, remains a topic of profound disagreement. Drawing on previously unpu
Objectives: North Sea–Progressive Myoclonus Epilepsy (NS-PME) is a rare, childhood-onset disorder primarily characterized by movement disorders including progressive myoclonus and ataxia; subsequently accompanied by varying degrees of epilepsy. While motor symptoms are clearly defined, quality of life (QoL) has never been investigated in NS-PME. Additionally, nonmotor symptoms (NMS) including anxi
There is a need for ground-breaking technologies to boost crop yield, both grains and biomass, and their processing into economically competitive materials. Novel cereals with enhanced photosynthesis and assimilation of greenhouse gasses, such as carbon dioxide and ozone, and tailored straw suitable for industrial manufacturing, open a new perspective for the circular economy. Here we describe the
Chapter 7, written by Vera Sadovska, Oksana Mont and Yuliya Voytenko Palgan, explores the economic sustainability of food-sharing initiatives (FSIs). Bringing together insights from a systematic literature review and empirical research in Barcelona, the chapter examines the economic challenges FSIs face, such as managing operational costs, obtaining funding and dealing with regulatory complexities
Denna artikel behandlar fyndet av en kota från en bardval som påträffades under utgrävningarna av Västra Karaby, en vendeltida boplats i västra Skåne. Fynd av bardvalar i skånska järnåldersboplatser är mycket sällsynta. I artikeln diskuteras kotans proveniens, kronologiska tillhörighet och betydelse för förståelsen av boplatsen. En taxonomisk bestämning av kotan har gjorts genom den benkemiska pep
Inventering av djurbensmaterialet från grävningarna i Västra Karaby 1969-1971. Även information om grävningen 1968. Innehåller anläggningslistor (med anläggningar innehållandes ben) samt översiktsplan med anläggningsnummer.
