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The package ParSeq is a Python software library for Parallel execution of Sequential data analysis. It implements a general analysis framework that consists of transformation nodes - intermediate stops along the analysis propagation to visualize data, display status and provide user input - and transformations that connect the nodes. ParSeq imports data into an adjustable data model - a collection

Obesity represents a global health challenge, with a critical and urgent need for long-term, sustainable management strategies. Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. At first approved for the treatment of type 2 diabetes mellitus, tirzepatide represents one of the latest clinically approved and commercia

In this paper, we study the function spaces D(μ) by Richter (1991) and Aleman (1993), and Dμ→ by Rydhe (2019). It is known that the forward shift Mz is bounded and expansive on D(μ), and therefore D(μ) coincides with a de Branges-Rovnyak space H[B]. We show that such a B is rational if and only if μ is finitely atomic, and this happens exactly when the corresponding defect operator has finite rank

This study examined Poles’ acculturation preferences profiles toward two groups: people from Ukraine and the Middle East, and their relation to perceived cultural distance. The study framework emphasizes the juxtaposition of media and political narratives surrounding migrants arriving in Poland. Representative data from 924 participants was analysed. Regarding the preference toward individuals fro

Glioblastoma (GBM), the most aggressive brain tumor in adults, is characterized by its infiltrative growth along the perivascular space. Mural cells (MCs), encompassing pericytes and smooth muscle cells, are multifunctional perivascular cells implicated in GBM progression. MCs not only facilitate vascular co-option but have also been suggested to contribute to the immunosuppressive tumor microenvi

In packaging, the structural integrity of paperboard under complex stresses is essential. This study examines the delamination behavior of paperboard under normal and shear loading modes, which are the base for developing mixed-mode models. Four commercial paperboard grades, sourced from fibers across three geographical regions, are investigated using Double Cantilever Beam (DCB) and Split Double

In light of the escalating global polycrisis—a convergence of environmental, social, and mental health crises—this paper explores the potential of mindfulness-based approaches for fostering human and planetary wellbeing and sustainability. We specifically investigate the linkages between Mindfulness-Based Stress Reduction (MBSR) and sustainability, and how they can be strengthened to support trans

Portable optically stimulated luminescence (pOSL) analysis allows rapid relative dating of sediments that potentially can be calibrated against known OSL ages to provide an age estimate for landforms across a large area. This study uses 186 pOSL measurements and 20 OSL ages to investigate the postglacial landscape evolution inside the Younger Dryas moraines in NE Finnmark and Finnish Lapland. Aeol

ImportanceThe management of complications following oral cavity squamous cell carcinoma (OCSCC) surgery can be challenging. Previous studies show conflicting results on complication risks after preoperative radiotherapy (RT), necessitating a randomized controlled trial (RCT).ObjectiveTo compare early complications during hospitalization for OCSCC surgery between patients receiving preoperative acc

Education for sustainability is widely recognised as a critical pathway for driving the transformations needed to address today’s polycrisis. Despite growing theoretical and conceptual advancements in sustainability education, current approaches have not achieved the deep systemic changes required. While university networks and individual institutions increasingly integrate sustainability into the

Denna artikel undersöker hur innebörden av ekonomisk ersättning kan omdefinieras över tid i svenska familjehemsföräldrars liv. Med utgångspunkt i fyrtio kvalitativa intervjuer visar jag att familjehemsföräldrar initialt kan tona ned eller bortse från de ekonomiska aspekterna av uppdraget, men senare komma att vara beroende av denna inkomst – inte nödvändigtvis av egenintresse, utan som ett sätt atThis article examines how the meaning of financial compensation may be redefined over time in the lives of Swedish foster parents. Drawing on forty qualitative interviews, I demonstrate that while foster parents may initially downplay or disregard the monetary aspects of fostering, they can later come to depend on this income, not necessarily out of self-interest, but as a means of deepening their

The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8+ T cell response pre-emptively, in the absence of an infection1. However, the scope and purpose of this anticommensal immune programme are not well defined, limiting our ability to harness it therapeutically. Here, we show that this colonist also induces a potent, durable and specific antibody response that is conserved in human

The microbiota colonizes each barrier site and broadly controls host physiology1. However, when uncontrolled, microbial colonists can also promote inflammation and induce systemic infection2. The unique strategies used at each barrier tissue to control the coexistence of the host with its microbiota remain largely elusive. Here we uncover that, in the skin, host-microbiota symbiosis depends on the

Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncovered a dominant role for type 2 innate lymphoid cells (ILC2s) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2s by androgens leads to a reductio

The development of vaccines based on outer membrane vesicles (OMV) that naturally bud off from bacteria is an evolving field in infectious diseases. However, the inherent inflammatory nature of OMV limits their use as human vaccines. This study employed an engineered vesicle technology to develop synthetic bacterial vesicles (SyBV) that activate the immune system without the severe immunotoxicity