Hypoxia occurs frequently in human cancers and promotes stabilization and activation of hypoxia inducible factor (HIF). HIF-1α is specific for the hypoxia response, and its degradation mediated by three enzymes EGLN1, EGLN2 and EGLN3. Although EGLNs expression has been found to be related to prognosis of many cancers, few studies examined DNA methylation in EGLNs and its relationship to prognosis

Andelen anställda som omfattas av kollektivavtal ligger sedan flera år på omkring 90 procent. Nästan lika hög är organisationsgraden bland arbetsgivarna om man mäter den som andelen anställda på arbetsmarknaden med en arbetsgivare som är med i en arbetsgivarorganisation.Den fackliga organisationsgraden har stabiliserats på närmare 70 procent, men med ökade skillnader mellan tjänstemän och arbetare

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The study of the interaction between music and language is a small but rather active branch of musicology and linguistics. The two disciplines seldom meet. In this study we add a linguistic approach to our ethnomusicological knowledge. The cultural setting under study is Kammu, an Austroasiatic language spoken mainly in Laos. Kammu is a tone language where each syllable has a tone, either High or

Seymour Mayne’s literary output is imbued with Canadian-fashioned multiculturalism. Additionally, an indefatigable search for his Jewish roots and Yiddish texts as preservers of ethnic memory involved his fictions and word-sonnets in a restorative approach. In spite of his academic profession, Mayne has a keen eye for landscape, nature and ecological implications. His subtlety resides in the mello

A series of trimethylsilyl-protected di-alkynes incorporating 3,4-ethylenedioxythiophene (EDOT) linker groups Me3Si–CC–R–CC–SiMe3 (R = ethylenedioxythiophene-3,4-diyl 1a, 2,2′-bis-3,4-ethylenedioxythiophene-5,5′-diyl 2a, 2,2′,5′,2′′-ter-3,4-ethylenedioxythiophene-5,5′′-diyl 3a) and the corresponding terminal di-alkynes, H–CC–R–CC–H 1b–2b has been synthesized and characterized and the single crysta

This report summarises the most important lessons learned from the research project From waste management to waste prevention. In the research project, researchers from Lund University and the University of Gothenburg, but also Umeå University and the Royal Institute of Technology, have studied waste prevention.The aim of the project has been to identify and clarify the difficulties in realising t

This paper investigates the accuracy of using the Woxén equivalent chip thickness to represent feed, depth of cut, nose radius and major cutting angle in tool life modeling of machining low alloy steel in longitudinal turning. Hägglund’s way of calculating the equivalent chip thickness has been used and compared to the Woxén equation. The equivalent chip thickness was held constant as the tool lif

The paper addresses the inverse heat transfer problem, in which the dependence of the flux on time is determined on the basis of the measured temperatures in remote points of the tool body. The nonlinear heat equation is considered since the properties of the tool material are temperature-dependent. The machining time interval is divided into subintervals within which the change in the tool materi

Superhard cBN-based materials with Cr3C2, Cr2N and CrB2 binders were sintered in a high-pressure high-temperature (HPHT) toroidal apparatus under a pressure of 7.7 GPa and in the temperature range of 1600-2450°С. Initial mixtures of three compositions were chosen with 60 vol.% of cBN, 35 vol.% of binder phase and 5 vol.% of Al. Phase composition and microstructure of sintered samples were investig

4H-4a,9-Methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) (CAS # 211299-54-6) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7