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Background: The diagnosis of monogenic obesity is burdened by frequent variants of uncertain significance (VUS). We describe our real-life approach of variant reassessment over time and we assess whether inconclusive variants are decreasing in monogenic obesity. Methods: We tested for monogenic obesity (genes: LEPR, POMC, ADCY3, PCSK1, CARTPT, SIM1, MRAP2, LEP, NTRK2, BDNF, KSR2, MAGEL2, SH2B1, MC

Investigating Li-ion batteries during high current rates is becoming increasingly important to advance fast charging of electric vehicles. Here, we use a state-of-the-art synchrotron instrument and detector to measure spatially resolved X-ray diffraction in operando on single-layer pouch cells at 1C and 3C. Using batch refinement on the hundreds of thousands of obtained diffractograms, the electro

Real wages are a convenient, useful, and powerful way to learn how life was like in the past. In this chapter we start by reviewing the methodology behind real wage estimations and their history. Then we look at the how real wages have contributed to shedding light on major issues in economic history such as the onset of modern economic growth, the Great Divergence, and colonialism in the Americas

Om kriget kommer eller en ny pandemi bryter ut har landets lärosäten både kompetens och kunskaper för att stötta samhället. Ändå har lärosätena lyst med sin frånvaro i samhällsdebatten. Det är hög tid att börja prata om hur lärosätenas kapacitet kan användas i en hälsokris, skriver 37 företrädare för Hälsokrisnätverket.

Understanding the structure-property relationship in electrocatalysts under working conditions is crucial for the rational design of novel and improved catalytic materials. This paper presents the Aarhus University reactor for electrochemical studies using X-rays (AUREX) operando electrocatalytic flow cell, designed as an easy-To-use versatile setup with a minimal background contribution and a uni

The ALICE Collaboration reports a search for jet quenching effects in high-multiplicity (HM) proton-proton collisions at s = 13 TeV, using the semi-inclusive azimuthal-difference distribution ∆φ of charged-particle jets recoiling from a high transverse momentum (high-pT,trig) trigger hadron. Jet quenching may broaden the ∆φ distribution measured in HM events compared to that in minimum bias (MB) e

The least squares estimator can be cast as depending only on the precision matrix of the data, similar to the weights of a global minimum variance portfolio. We give conditions under which any plug-in precision matrix estimator produces an unbiased and consistent least squares estimator for stationary time series regressions, in both low- and high-dimensional settings. Such conditions define a cla

Objective: To describe healthcare professionals’ perception of current early rehabilitation practices and their preconditions, focusing on functional and cognitive stimulation facilitated by nurses and other healthcare professionals in Scandinavian intensive care units (ICUs). Design: Cross-sectional electronic survey administered to healthcare professionals. The survey was developed in Danish, tr

Lately, interest has increased in using Virtual Reality (VR) in residential care facilities to increase accessibility to nature experiences. It is widely acknowledged that nature benefits health, and various theories exist regarding its restorative effects. Studies of virtual natural environments often start from predetermined mediating mechanisms and health outcomes. However, virtual nature is fu

The azimuthal anisotropy of particles associated with jets (jet particles) at midrapidity is measured for the first time in p-Pb and Pb-Pb collisions at sNN = 5.02 TeV down to transverse momentum (pT) of 0.5 GeV/c and 2 GeV/c, respectively, with ALICE. The results obtained in p-Pb collisions are based on a novel three-particle correlation technique. The azimuthal anisotropy coefficient v2 in high-

The production yields of the Σ(1385)± and Ξ(1530)0 resonances are measured in pp collisions at s = 13 TeV with ALICE. The measurements are performed as a function of the charged-particle multiplicity ⟨dNch/dη⟩, which is related to the energy density produced in the collision. The results include transverse momentum (pT) distributions, pT-integrated yields, mean transverse momenta of Σ(1385)± and Ξ

The focus of this study is the direct interactions of the local turbulent fields and single drops inside the anisotropic turbulent field of a high-pressure homogenizer valve scale-up model. A volume of fluid scheme is incorporated into a direct numerical simulation approach to study the deformation and breakup of drops. The numerical framework was validated by experiments in a previous study. Ther

During human embryogenesis, distinct waves of hematopoiesis give rise to various blood cell types, originating from hemogenic endothelial (HE) cells. As HE cells reside in hypoxic conditions in the embryo, we investigated the role of hypoxia in human endothelial to hematopoietic transition and subsequent hematopoiesis. Using single-cell RNA sequencing, we describe hypoxia-related transcriptional c

AU The:information Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly contained in population genomic data can tell : us much about the past ecology and evolution of species. We leveraged detailed phenotypic and genomic data of nearly all living kākāpō to understand the evolution of its feather color polymorphism. The kākāpō is an endangered and culturally significant parrot endemic to Aotea

Background: In 2020, the coronavirus disease 2019 (COVID-19) pandemic caused disruptions in kidney replacement therapy (KRT) services worldwide. The aim of this study was to assess the effect of the COVID-19 pandemic in 2020 on the incidence of KRT, kidney transplantation activity, mortality and prevalence of KRT across Europe. Methods: Patients receiving KRT were included from 17 countries provid