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Engineered affibody molecules can be used for high contrast in vivo molecular imaging. Extending a recombinantly produced HER2 binding affibody molecule with a hexa-histidine tag allows for convenient purification by immobilized metal-ion affinity chromatography and labeling with [(99m)Tc(CO)3](+) but increases radioactivity uptake in the liver. To investigate the impact of charge, lipophilicity,
PURPOSE: Radionuclide imaging of insulin-like growth factor type 1 receptor (IGF-1R) expression in tumours might be used for selection of patients who would benefit from IGF-1R-targeted therapy. We have previously shown the feasibility of IGF-1R imaging using the Affibody molecule (111)In-DOTA-His(6)-Z(IGF1R:4551). The use of (99m)Tc instead of (111)In should improve sensitivity and resolution of
Affibody molecules are a class of affinity proteins. Their small size (7 kDa) in combination with the high (subnanomolar) affinity for a number of cancer-associated molecular targets makes them suitable for molecular imaging. Earlier studies demonstrated that the selection of radionuclide and chelator may substantially influence the tumor-targeting properties of affibody molecules. Moreover, the p
Chemicals is the industrial sector with the highest energy demand, using a substantial share of global fossil energy and emitting increasing amounts of greenhouse gasses following rapid growth over the past 25 years. Emissions associated with energy use have increased with growth in coal-dependent regions but are also commonly underestimated in regions with higher shares of renewable energy. Renew
In 2016, the Norwegian government initiated an extensive reform of the regional scale, eventually reducing the number of political-administrative counties from nineteen to eleven through mergers. The territorial and institutional changes that followed can be understood as a partial regional (de/re)institutionalisation process, in which the political and administrative boundaries of the merged coun
Abstract på spanskaUna de las fuentes más sólidas de nuevo conocimiento sobre las categorías tipológicas proviene de nuestro creciente entendimiento de las lenguas indígenas de América del Sur, una región que hasta hace poco ha estado significativamente subrepresentada en los estudios tipológicos. Este artículo ofrece un ejemplo a través de la investigación del número en nadëb, un miembro de la peOne of the most robust sources of fresh insights into typological categories comes from our growing knowledge of the indigenous languages of South America, a region that until recently has been significantly under-represented in typological studies. This paper offers a case in point through the investigation of number in Nadëb, a member of the small Naduhup family of the northwest Amazon, which re
Nominal classification is a robust feature in many Amazonian languages, and aspects of these systems offer significant challenges to our broader conception of the phenomenon. Yet a clear characterization of Amazonian classification systems must be firmly grounded in detailed descriptive analysis on one hand, and in a principled definition of classification as a typological category on the other –
Not all spatial adjuncts behave alike. In some languages, certain spatial adjuncts display different marking or different combinatorial possibilities than others. Recent functional-typological studies make two claims about this differential place marking phenomenon: (1) it is primarily motivated by noun semantics, opposing place names and other nouns; and (2) it is primarily realized as a contrast
Levinson (2003) provides evidence that distinct cultures display distinct spatial references that, as a consequence, impacts the linguistic encoding of spatial notions. This linguistic variation has fostered the interest of understanding the spatial domains responsible for the linguistic encoding of spatial information. According to Levinson and Wilkins (2006, p. 2), these domains consist in: the
Abstract in Portuguese:Referências a paisagens e lugares são elementos centrais nas narrativas tradicionais de falantes da língua Dâw (Naduhup,Amazônia brasileira). Essa ênfase na referência espacial é estabelecida principalmente por meio de orações adverbiaislocativas que são frequentemente repetidas ao longo do discurso. Sua função é relacionar um evento a um lugar, estabelecerreferência à inforReferences to landscape and places are central in traditional narratives by speakers of Dâw (Naduhup, Brazilian Amazon). This emphasis on spatial reference is primarily established through locative adverbial clauses that are often repeated throughout the discourse. Their function is to relate an event to a place, establish reference to locative information mentioned earlier in discourse, and provi
Abstract på portugisiska As línguas diferem umas das outras em relação a se, e, como, elas categorizam nomes a partir de critérios lexicais e gramaticais específicos. Um exemplo bastante estudado é a distinção entre nomes contáveis e massivos, que divide os nomes de acordo com sua capacidade de serem contados ou medidos. Comparações entre as línguas sobre esse sistema de categorização nominal mostLanguages differ with respect to if and how they categorize their nouns based on specific lexical or grammatical criteria. A well-studied example is the mass/count distinction, which groups nouns according to their ability to be counted or measured. Cross-linguistic comparison on this noun-categorization system provided evidence that the mass/count distinction is not a reflection of pre-linguistic
Complex predication is understood to be a highly productive processin Northwestern Amazonian languages in which complex predicates may berealized as compounds, verb-auxiliary constructions or serial verb constructions depending on language-internal criteria. These constructions play an important role in the organization of discourse and information packaging and can also carry out grammatical func
Research concerning endangered languages has evolved from research on such languages, to research for their speaker communities, and more recently to research with speakers of endangered languages (Grinevald & Bert 2011:62). Such collaborations between communities and linguists are by now considered best practice and an idealized goal (Leonard & Haynes 2010) to foster more equitable relati
We present the discovery of two small planets transiting HD 93963A (TOI-1797), a GOV star (M* = 1.109 ± 0.043M⊙, R* = 1.043 ± 0.009 R⊙) in a visual binary system. We combined TESS and CHEOPS space-borne photometry with MuSCAT 2 ground-based photometry, ‘Alopeke and PHARO high-resolution imaging, TRES and FIES reconnaissance spectroscopy, and SOPHIE radial velocity measurements. We validated an
Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain fatty acids (SCFAs), have been shown to positively influence lipid profile and biomarkers in the gut and brain. This study examined whether MB and MV in high-fat diets, affected microbiota composition and gut–blood–brain markers in apolipoprotein E deficient (ApoE-/-) rats, a model for studies of lipid-associated disorders,
