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Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease.

IL-5 is a Th2 cytokine which activates eosinophils and is suggested to have an atheroprotective role. Genetic variants in the IL5 locus have been associated with increased risk of CAD and ischemic stroke. In this study we aimed to identify genetic variants associated with IL-5 concentrations and apply a Mendelian randomisation approach to assess IL-5 levels for causal effect on intima-media thickn

Swedish randomized controlled trial of cardiotocography only versus cardiotocography plus ST analysis of fetal electrocardiogram revisited: analysis of data according to standard versus modified intention-to-treat principle.

Objective. To undertake a renewed analysis of data from the previously published Swedish randomized controlled trial on intrapartum fetal monitoring with cardiotocography (CTG-only) vs. CTG plus ST analysis of fetal electrocardiogram (CTG+ST), using current standards of intention-to-treat (ITT) analysis and to compare the results with those of the modified ITT (mITT) and per protocol analyses. Met

Procedure for determining the biodegradation of radiolabeled substrates in a calcareous soil.

Calcareous soils are frequently typified by a low availability of plant nutrients due to poor solubility of these elements at high pH. Calcicole plants have recently been shown to release organic acids in response to the nutrient deficient conditions prevailing in these soils. It has been speculated, however, that the efficiency of this nutrient mobilization mechanism may be significantly reduced

Multi-configuration Hartree and Dirac-fock Calculations of Atomic Hyperfine Structures

Recent multi-configuration Hartree-Fock (MCHF) calculations of atomic hyperfine structures are reviewed. In particular, spin-polarization and relativistic effects are considered. Using a systematic active space MCHF approach, combined with large multi-reference configuration interaction (MR-CI) calculations, it is shown that hyperfine structures in many cases can be calculated very accurately. For

Det hotade grevskapet : Per Brahe den yngres minnesmärken

The threatened estate - the memorails of Per Brahe junior On the background of the present research on memorials and monuments follows a study of a number of memorials erected by the count Per Brahe junior between 1653 and 1680 on Visingsö and in Skärstad in Småland, at Dimbo in Västergötland and Östra Ryd in Uppland. The memorials belong to a period, when his county Visingsborg in Sweden and baro

Renal Transplant Patients at High Risk of Acute Rejection Benefit From Adequate Exposure to Mycophenolic Acid.

BACKGROUND.: To better define subpopulations in which achieving adequate mycophenolic acid (MPA) concentrations quickly would be important, a post hoc exploratory analysis on the fixed-dose concentration-controlled database was performed, comparing high- versus low-risk renal transplant patients. METHODS.: Renal transplant patients were treated with mycophenolate mofetil, corticosteroids, and cycl

Does peer benefit justify research on incompetent individuals? The same-population condition in codes of research ethics.

Research on incompetent humans raises ethical challenges, especially when there is no direct benefit to these research subjects. Contemporary codes of research ethics typically require that such research must specifically serve to benefit the population to which the research subjects belong. The article critically examines this "same-population condition", raising issues of both interpretation and

Numerical Simulation of Combustion and Gasification of Biomass Particles

Popular Abstract in English Most of us are familiar with using plant-derived material such as wood for producing heat for warming the cottages or cooking food when we are camping. Apart from that, plant-derived materials such as trees, forest residues, grasses, agricultural crops, agricultural residues and straw have great potential in producing energy in a larger scale. This group of material is In this thesis, a numerical approach is adopted to study biomass thermochemical conversion. Detailed physical and chemical processes involved in the thermochemical conversion of biomass are considered. The aims are to improve the understanding of the physical and chemical processes involved and to develop and validate mathematical models for numerical simulation of the biomass conversion process.

Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study.

Context: The diagnosis of late-onset hypogonadism (LOH) in older men with age-related declines in testosterone (T) is currently not well characterized. Objective: Our objective was to investigate whether different forms of hypogonadism can be distinguished among aging men. Design: The study was a cross-sectional survey on 3369 community-dwelling men aged 40-79 yr in eight European centers. Methods

Beyond the legacy of the Enlightenment? Online encyclopaedias as digital heterotopias

This article explores how we can understand contemporary participatory online encyclopaedic expressions, particularly Wikipedia, in their traditional role as continuation of the Enlightenment ideal, as well as in the distinctly different space of the Internet. Firstly we position these encyclopaedias in a historical tradition. Secondly, we assign them a place in contemporary digital networks which

Sphingolipids in human ileostomy content after meals containing milk sphingomyelin.

BACKGROUND: Sphingomyelin occurs in modest amounts in the diet, in sloughed mucosal cells, and in bile. It is digested by the mucosal enzymes alkaline sphingomyelinase and ceramidase. In humans, alkaline sphingomyelinase is also secreted in bile. The digestion of sphingomyelin is slow and incomplete, which has been linked to the inhibition of cholesterol absorption and colonic carcinogenesis. OBJE