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Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike
We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data
Meningitis is a potentially life-threatening infection characterized by the inflammation of the leptomeningeal membranes. Many different viral and bacterial pathogens can cause meningitis, with differences in mortality rates, risk of developing neurological sequelae and treatment options. Here we constructed a compendium of digital cerebrospinal fluid (CSF) proteome maps to define pathogen-specifi
Disasters are typically conceptualised as extreme events that disrupt the “normal” functioning of a society. Dominant framings imply temporal boundedness and nature as primarily responsible for environmental disasters. Yet, many critical investigations into the root causes of disasters have taken aim at their eventfulness and naturalness through convincing analysis of the historical construction o
Background: High red cell distribution width (RDW) has been increasingly recognized as a risk factor for cardiovascular diseases (CVDs), but the underlying mechanisms remain unknown. Our aim was to explore the associations between RDW and plasma proteins implicated in the pathogenesis of CVD using a targeted proteomics panel. Methods: RDW and 88 plasma proteins were measured in a population-based
Introduction: Plasma glial fibrillary acidic protein (GFAP) is a marker of astroglial activation and astrocytosis. We assessed the ability of plasma GFAP to detect Alzheimer’s disease (AD) pathology in the form of AD-related amyloid-β (Aβ) pathology and conversion to AD dementia in a mild cognitive impairment (MCI) cohort. Method: One hundred sixty MCI patients were followed for 4.7 years (average
Discordant U–Pb data of zircon are commonly attributed to Pb loss from domains with variable degree of radiation damage that resulted from α-decay of U and Th, which often complicates the correct age interpretation of the sample. Here we present U–Pb zircon data from 23 samples of ca. 1.7–1.9 Ga granitoid rocks in and around the Siljan impact structure in central Sweden. Our results show that zirc
Syftet med denna rapport är att diskutera om Sverige bör överge det nuvarande ramverkets regler och följa med i den internationella trenden med kraftigt ökad offentlig skuldsättning. Vårt svar är nej. Argumenten för att överge det nuvarande ramverket är svaga. Vi får inte glömma att ramverket bidragit till årtionden av ekonomisk stabilitet i Sverige – inte minst nu under coronakrisen. Eventuella r
Background: This study aimed to explore associations between various elements of primary care, patient satisfaction, and loyalty. Methods: This cross-sectional study used a modified version of the Primary Care Assessment Tool (PCAT), which was adapted for Japan. We distributed the PCAT questionnaire to patients aged 20 years or older at five rural primary care centres in Japan. We confirmed the va
In order to tap the energy saving and climate mitigation potential of buildings, transaction costs of implementing energy efficient technologies need to be better understood and ultimately reduced. The objective of this paper is to identify and analyze the nature and scale of transaction costs resulting from the application of the passive house concept in energy efficient renovations. Related conc
We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18–44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N
Background: Left ventricular longitudinal strain (LVLS) may be a sensitive indicator of left ventricular (LV) systolic function in patients with sepsis, but is dependent on high image quality and analysis software. Mitral annular plane systolic excursion (MAPSE) and the novel left ventricular longitudinal wall fractional shortening (LV-LWFS) are bedside echocardiographic indicators of LV systolic
With their potential to effectively address multiple urban sustainability challenges, the emerging policy discourse on nature-based solutions seeks to encourage the development of multifunctional nature for sustainable and just cities. Nature-based solutions, however, are vulnerable to co-option by powerful interests in ways that limit their contribution to a broad range of sustainability goals. RWith their potential to effectively address multiple urban sustainability challenges, the emerging policy discourse on nature-based solutions seeks to encourage the development of multifunctional nature for sustainable and just cities. Nature-based solutions, however, are vulnerable to co-option by powerful interests in ways that limit their contribution to a broad range of sustainability goals. R
Background: Trans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone receptor-defined molecular subtypes, menopausal status, and body size have rarely been conducted. Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC),
The lakes on the Yangtze Plain, a critical source of freshwater and fisheries for hundreds of millions of people in China, have lost a considerable portion of their surface area due to reclamation since the 1950s. Landsat satellites can provide long-term collections of high-resolution images and thus offer great potential for hindcasting the lake reclamations of aquaculture zones and their long-te
In this paper, paraffin mixed with nanoparticles Al2O3, CuO, and multi-walled carbon nanotubes (MWCNTs) were prepared for cooling multiple heat sources. For thermal management of heat sources, performances of the composite phase change materials (PCMs) were investigated at different heating power. Enhanced performance in terms of heat sources temperature, temperature difference between two heat so
Water purification is one of the most essential services provided by wetlands. A lot of concerns regarding wetlands subjected to climate change relate to their susceptibility to hydrological change and the increase in temperature as a result of global warming. A warmer condition may accelerate the rate of decomposition and release of nutrients, which can be exported downstream and cause serious ec
This article explores the transformative role of practices of countering digital disinformation in European Union diplomacy. It argues that an overlooked dimension of the change brought by the rise of digital disinformation is located in the emergence of everyday countering practices. Efforts to counter disinformation have led to the recruitment of new actors with different dispositions and skills
The mobile research lab is an emerging research methodology increasingly applied in urban studies to investigate phenomena like places, infrastructures, nature and inhabitants of cities. This essay critically explores this relatively new methodology, also known as ‘mobile labs’, as part of in-situ research for a two-year research project supported by the International Fellowship Program of the JapThe mobile research lab is an emerging research methodology increasingly applied in urban studies to investigate phenomena like places, infrastructures, nature and inhabitants of cities. This essay critically explores this relatively new methodology, also known as ‘mobile labs’, as part of in-situ research for a two-year research project supported by the International Fellowship Program of the Jap
