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Development of Gene Therapy for Malignant Osteopetrosis

Richter Group Our Research Osteoclasts and osteoblasts are two important mediators in the tightly regulated process of bone remodelling. The bone-forming osteoblasts are of mesenchymal origin while the multinucleate osteoclasts, which are responsible for bone resorption, are derived from hematopoietic stem cells (HSCs). An imbalance between the production and destruction of bone can lead to either

https://www.stemcellcenter.lu.se/research-groups/richter - 2025-08-09

UniStem Day

Welcome to the never-ending journey of stem cell research! UniStem Day is the largest educational outreach initiative on stem cells and regenerative medicine in Europe, bringing together Universities and high school students. UniStem Day began as a project by the University of Milan in Italy in 2009. In 2019, UniStem Day became a worldwide event spreading across four continents, involving 99 Unive

https://www.stemcellcenter.lu.se/education/public-outreach/unistem-day - 2025-08-09

Take Science to Schools - Borrow a Scientist

To connect research with the classroom, the Research School in Stem Cell Biology at the Lund Stem Cell Center started the new "Take Science to Schools – Borrow a Scientist," bringing researchers into local high schools to give students a unique look at the world of stem cell research and the everyday life of scientists. The program, which was first launched in 2019 by the Research School in Stem C

https://www.stemcellcenter.lu.se/education/public-outreach/take-science-schools-borrow-scientist - 2025-08-09

Kulturnatten i Lund

Culture Night in Lund Cellular Canvas: A Scientific Art Exhibition by Lund Stem Cell Center Since 2023, the Lund Stem Cell Center has proudly presented its Cellular Canvas Exhibition during Culture Night in Lund. This special exhibition showcases a stunning collection of scientific images that vividly display and explain the leading science conducted at the Center. Each image is a part of the Cent

https://www.stemcellcenter.lu.se/education/public-outreach/kulturnatten-i-lund - 2025-08-09

Annual Image Competition

Combining art and science creates a special energy that boosts creativity, enhances understanding, and enriches the human experience. This peaceful coexistence has been shown to lead to significant developments and valuable insights in both fields. Embracing this, the Lund Stem Cell Center proudly hosts an annual Image Competition that has become a popular tradition since its start in 2020. The co

https://www.stemcellcenter.lu.se/education/public-outreach/annual-image-competition - 2025-08-09

Lymphoid Development and Regulation

SITNICKA QUINN Group Our ResearchThe immune system is composed of myeloid and lymphoid cells that collectively protect the body from bacteria, parasites, fungi, or viruses, and from the growth of tumor cells. Hematopoietic stem cells (HSCs) are ultimately responsible for the production of all cells in the immune system. Throughout a lineage commitment process, multipotent HSCs differentiate and ge

https://www.stemcellcenter.lu.se/research-groups/sitnicka_quinn - 2025-08-09

Developmental Immunology

Yuan Group Our researchOur research addresses important gaps in our knowledge of how nature and nurture shape the formation of a complex and balanced immune system with important implications in life-long health and the origin of B cell cancers.  Our lab has previously identified a critical regulator of fetal lymphopoiesis, LIN28B, that endows hematopoietic stem and progenitor cells to regenerate

https://www.stemcellcenter.lu.se/research-groups/yuan - 2025-08-09

Stem cells to red blood cells

Flygare Group Our Research84% of all cells in our bodies are red blood cells. Today many anemic patients suffer from inefficient production of these essential cells. We believe safer and more effective therapies can be developed based on advances in understanding the process of red cell production.To understand the developmental process of red blood cell formation:My group became the first to demo

https://www.stemcellcenter.lu.se/research-groups/flygare - 2025-08-09

Steering Group

The Lund Stem Cell Center Steering Group is a team of dedicated researchers who drive the strategic planning and scientific progress of the Center. The Steering Group's primary goal is to ensure that the Center's research is focused, impactful, and innovative. They are responsible for developing and implementing the Center's strategic plan, ensuring that resources are used effectively, and fosteri

https://www.stemcellcenter.lu.se/lund-stem-cell-center/stem-cell-center-steering-group - 2025-08-09

Hematopoietic Stem Cell Transplantation

Juliusson Group Our Research  We focus on clinical aspects of acute myeloid leukemia (AML) in adults. Patients with AML are diagnosed, including extensive genetic analyses with constitutional control DNA and biobanking, and treated according to research and routine protocols at Skåne University Hospital, Lund, with careful monitoring and follow-up.  Lab work includes genetics in collaboration with

https://www.stemcellcenter.lu.se/research-groups/juliusson - 2025-08-09

Laboratory of Molecular Neurogenetics

Jakobsson Group Our ResearchWe are interested in how gene expression is regulated in the brain and how this process influence neurodegenerative diseases, psychiatric disorders and brain tumors. Our current focus is to study the role of epigenetic mechanisms and microRNAs. Our technical expertise include lentiviral vectors, transgenic mice and stem cells cultures.AimsTo understand the role of the e

https://www.stemcellcenter.lu.se/research-groups/jakobsson - 2025-08-09

StemTherapy Board

Academic staff representatives: Coordinator and Chairman: Johan Jakobsson, Professor, Department of Experimental Medical Science, Lund University Deputy Coordinator: Johan Flygare, Associate Professor, Department of Laboratory Medicine, Lund University David Bryder, Professor, Department of Laboratory Medicine, Lund University Oommen Varghese, Associate Professor, Department of Medical Cell Biolog

https://www.stemcellcenter.lu.se/lund-stem-cell-center/stemtherapy-board - 2025-08-09

Stem Cells and Leukemia

G. Karlsson group Our ResearchThe production of blood cells, hematopoiesis, is maintained by a small number of hematopoietic stem cells (HSCs) that have the capacity to differentiate into all hematopoietic lineages, and at the same time self-renew to maintain the HSC pool. These properties make HSCs essential for maintaining hematopoietic homeostasis and for reconstitution of patients during treat

https://www.stemcellcenter.lu.se/research-groups/gkarlsson - 2025-08-09

Scientific Advisory Board

The Scientific Advisory Board (SAB) is an international team of esteemed researchers in the fields of basic and translational stem cell research. Comprised of experts from top research institutions around the world, the SAB provides invaluable strategic advice and recommendations to the Lund Stem Cell Center's Steering Group and Management Team.As a key part of the Center's leadership structure, t

https://www.stemcellcenter.lu.se/lund-stem-cell-center/stemtherapy-scientific-advisory-board - 2025-08-09

Development of advanced cell therapies using hematopoietic stem cells

S. Karlsson Group Our ResearchWe are studying the regulation of hematopoietic stem cells (HSCs) in order to understand how signaling pathways, transcriptional mechanisms and epigenetic regulators govern stem cell behavior to determine stem cell fate options.Integrative signaling and transcriptional networks act in concert to determine whether hematopoietic stem cells remain quiescent, proliferate

https://www.stemcellcenter.lu.se/research-groups/skarlsson - 2025-08-09

Laboratory of Stem Cells and Restorative Neurology

Kokaia group AimBy linking together basic and clinical research, we aim to clarify cellular mechanisms of regeneration following damage to the brain and develop new therapeutic strategies to restore function in this organ (primarily in stroke and Parkinson’s disease) by transplantation of stem cells or reprogrammed cells and optimization of endogenous repair mechanisms.  Our ResearchAvailable expe

https://www.stemcellcenter.lu.se/research-groups/laboratory-stem-cells-and-restorative-neurology - 2025-08-09

Stem Cell Regulators

Larsson Group Our researchThe focus of the research in the Larsson group is to define genes and pathways that regulate human hematopoietic stem cells (HSCs) and to develop novel strategies for ex vivo stem cell expansion to enhance current cell therapies of hematological disorders. Over the last few years the laboratory has developed strategies to screen for modifiers of self-renewal/proliferation

https://www.stemcellcenter.lu.se/research-groups/larsson - 2025-08-09

Research

Researchers at Lund University already have a strong international position in two major areas of somatic stem cell and cell therapy research: Neural cell replacement therapies for central nervous system (CNS) disorders Hematopoietic stem cell (HSC) biology and gene therapyThe sections of Neurobiology and Restorative Neurology have an internationally leading position in CNS disease models and expe

https://www.stemcellcenter.lu.se/research - 2025-08-09

Endocrine Cell Differentiation

Artner Group Our Research Diabetes results from loss or dysfunction of insulin producing beta cells in the pancreas. Despite insulin injection treatment, diabetic patients suffer from long-term complications, such as blindness and kidney failure. Therefore, a central goal of diabetes research is to regenerate pancreatic beta cells or produce large numbers of functional beta cells for transplantati

https://www.stemcellcenter.lu.se/research-groups/artner - 2025-08-09

Vertebrate Developmental Biology

Pera Group Our Research  In our research, we are studying extracellular signals in embryonic development and cancer. Particular emphasis is given to mechanisms that regulate pattern formation and collective cell migration in the vertebrate embryo. The neural crest is a multipotent and highly motile cell population that arises at the border of the neural plate, delaminates and colonizes a wide vari

https://www.stemcellcenter.lu.se/research-groups/pera - 2025-08-09