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The presence of immune cells in the tumor microenvironment has been associated with response to immunotherapies across several cancer types, including melanoma. Despite its therapeutic relevance, characterization of the melanoma immune microenvironments remains insufficiently explored. To distinguish the immune microenvironment in a cohort of 180 metastatic melanoma clinical specimens, we develope
The inorganic metal or metal-oxide nanoparticles (NPs) that mimic enzymes are of great interest due to improved physical and chemical properties compared with native enzymes. Here, we report that manganese dioxide (MnO2)-Silk exhibit catalase, oxidase, and peroxidase-like activities. The MnO2-Silk hybrid fibers effectively decomposed hydrogen peroxide (H2O2) and oxidized the typical horseradish pe
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and summary statistics from the hitherto largest GWAS m
BACKGROUND: The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially biased. Prospective studies have had limited power, particularly for BRCA2 mutation carriers. Further, previous studies have not considered the effect of RRSO in the context
Purpose: This paper aims to investigate the nature and dynamics of the interaction between university spin-offs (USOs) and academia. Design/methodology/approach: The theoretical framework is grounded in an interactive view based on the industrial marketing and purchasing literature on USOs and their development. The concepts of activity links, resource ties and actor bonds are used as a starting p
The emergence of nodding syndrome (NS) in Northern Uganda has generated controversial views with respect to patterns, natural history, and aetiology of the disease which is yet unknown. This study explored spatial patterns of NS using spatial-temporal methods to establish its clustering patterns across both space and time. Village and year of NS onset for individual patients between the years 1990
Socialminister Hallengren måste ompröva sin ståndpunkt. Att utesluta kriminaliseringen av narkotikabruk från den kommande utredningen vore ett allvarligt misstag, menar experterna Björn Johnson och Petter Karlsson.
This paper extends the half-panel jackknife (HPJ) estimator to GMM models with fixed effects. The Monte Carlo results show that the HPJ significantly reduces finite-sample bias for both the difference and system GMM estimators of the dynamic panel model.
The compelling images and promises attached to autonomous drive vehicles can easily create an impression that one can speak of a radical distinction between a self-driving future and a manual-driving present. Yet today’s drivers can already refer to their everyday driving as being experienced as though on ‘auto-pilot’, in which they are able to drive their cars while lost in things such as daydrea
Om mordet på Caesar.
The capacity to assemble, store, and make available information in databases is ever growing. This development has accelerated in recent decades, driven by the advent and increased use of digital networks. Already at an early stage, it led to demands for legal protection of databases. In most countries databases have been protected in national legislation based on copyright principles. However, th
Background & Objective: Patients with mild hypothyroidism often are depressed and have impaired quality of life despite serum free-T4 and T3 within reference values. Therefore, we investigated whether their symptoms were dependent on the concentrations of free -T4 and T3 in the circulation and cerebrospinal fluid (CSF). Methods: Twenty-five newly diagnosed, untreated hypothyroid subjects and a
