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A Novel Molecularly Imprinted Polymer for the Selective Removal of Chlorophyll from Heavily Pigmented Green Plant Extracts prior to Instrumental Analysis

A novel molecularly imprinted polymer (MIP) powder designed for the selective removal of interfering chlorophyll pigment from heavily pigmented green plant extracts during pesticide residue analysis or analysis for bioactives in natural product research is reported. The polymer powder imprinted with chlorophyll.. was synthesized by copolymerizing the functional and cross-linking monomers, methacry

Multi-century reconstruction of fire activity in Northern European boreal forest suggests differences in regional fire regimes and their sensitivity to climate

Forest fires are one of the main disturbance agents in boreal and temperate ecosystems. To decipher large-scale temporal and spatial patterns of past fire activity in Scandinavia, we analysed the synchronicity of dendrochoronologically reconstructed fire events in a large network of sites (n=62; 3296 samples, 392 individual fire years) covering a wide geographical gradient (56.5-67.0 degrees N and

Numerical compression schemes for proteomics mass spectrometry data.

The open XML format mzML, used for representation of mass spectrometry (MS) data, is pivotal for the development of platform-independent MS analysis software. Although conversion from vendor formats to mzML must take place on a platform on which the vendor libraries are available (i.e. Windows), once mzML files have been generated, they can be used on any platform. However, the mzML format has tur

Assessment of Porosities of SBA-15 and MCM-41 Using Water Sorption Calorimetry.

Water sorption calorimetry has been used for characterization of 2D hexagonally ordered mesoporous silica SBA-15. Experimental data on water sorption isotherm, the enthalpy, and the entropy of hydration of SBA-15 are presented. The results were compared with previously published results on MCM-41 obtained using the same technique. The water sorption isotherm of SBA-15 consists of four regimes, whi

Advancing the global proteome survey platform by using an oriented single chain antibody fragment immobilization approach.

Increasing the understanding of a proteome and how its protein composition is affected by for example different diseases, such as cancer, has the potential to improve strategies for early diagnosis and therapeutics. The Global Proteome Survey or GPS is a method that combines mass spectrometry and affinity enrichment with the use of antibodies. The technology enables profiling of complex proteomes

Circulating MicroRNA Expression Profiles Associated With Systemic Lupus Erythematosus

Objective To evaluate the specificity of expression patterns of cell-free circulating microRNAs (miRNAs) in systemic lupus erythematosus (SLE). Methods Total RNA was purified from plasma, and 45 different specific, mature miRNAs were determined using quantitative reverse transcriptionpolymerase chain reaction assays. A total of 409 plasma samples were obtained from 364 different patients with SLE,

Building authentic midbrain dopaminergic neurons from stem cells - lessons from development

The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of f

Multimodal Detection of Iron Oxide Nanoparticles in Rat Lymph Nodes Using Magnetomotive Ultrasound Imaging and Magnetic Resonance Imaging

Detection and removal of sentinel lymph nodes (SLN) is important in the diagnosis and treatment of cancer. The SLN is the first regional lymph node draining the primary tumor, and if the cancer has spread, it is most likely to find metastases in the SLN. In this study, we have for the first time been able to image the very same contrast agent, superparamagnetic iron oxide nanoparticles (SPIO-NPs),

A luminescence study of doping effects in InP-based radial nanowire structures

We have used micro-photo-and cathodo-luminescence at low temperatures to study the effects of sulphur doping in InP and radial InP/InAs/InP structured nanowires. Samples with pure wurtzite crystal structure, with modulated wurtzite/zincblende crystal structure and with different radial InAs growth times were investigated. We observed a doping concentration gradient along the nanowires, the locatio

Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease.

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features of manifesting LRRK2 mutation carriers are generally indistinguishable from those of patients with sporadic PD. However, some PD cases associated with LRRK2 mutations lack Lewy bodies (LBs), a neuropathological hallmark of PD. We investigated whether th

Emesis and gastrointestinal problems during radiotherapy A comparison of performance of daily activities between patients experiencing nausea and patients free from nausea

Purpose of the research To describe the experiences of nausea vomiting and gastrointestinal problems during radiotherapy and to compare patients experiencing nausea with patients not experiencing nausea regarding performance in daily activities sleeping and eating capacity Methods and sample A cross-sectional sample of 131 Swedish radiotherapy patients answered a questionnaire regarding the preced

Dating of a muskox (Ovibos moschatus) skull fragment from Jamtland, Sweden: Middle Weichselian age

A radiocarbon age determination of a tundra muskox (Ovibos moschatus) skull fragment from Jamtland, central Sweden gave an age of 44 000 +/- 1500 C-14 years BP or c. 46-49 cal. ka, indicating that the species was a member of the Middle Weichselian fauna of Sweden. The age confirms that central Sweden was ice-free during parts of the Middle Weichselian, prior to the last glacial maximum, as shown b

13-Valent pneumococcal conjugate vaccine (PCV13) in children partially immunized with 7-valent pneumococcal conjugate vaccine (PCV7): A phase 3, open-label trial

Background: As 13-valent pneumococcal conjugate vaccine (PCV13) is introduced, children who began vaccination with 7-valent pneumococcal conjugate vaccine (PCV7) may complete their vaccination with PCV13. This open-label phase 3 study evaluated immunogenicity and safety of PCV13 in Swedish infants and toddlers previously given 1 or 2 doses of PCV7 during infancy. Methods: Healthy infants previousl

Vortices in Bose-Einstein condensates: Finite-size effects and the thermodynamic limit

For a weakly interacting Bose gas rotating in a harmonic trap we relate the yrast states of small systems (that can be treated exactly) to the thermodynamic limit (derived within the mean-field approximation). For a few dozens of atoms, the yrast line shows distinct quasiperiodic oscillations with increasing angular momentum that originate from the internal structure of the exact many-body states.

BAP1 Plays a Survival Role in Cutaneous Melanoma.

Although the pattern of BAP1 inactivation in ocular melanoma specimens and in the BAP1 cutaneous/ocular melanoma (CM/OM) predisposition syndrome suggests a tumor suppressor function, the specific role of this gene in the pathogenesis of cutaneous melanoma is not fully understood. We thus set out to characterize BAP1 in cutaneous melanoma and discovered an unexpected pro-survival effect of this pro

Definitioner av våld i överlevandes berättelser efter kriget i Bosnien

Tidigare forskning som berör våldet under kriget i Bosnien och Hercegovina presenterar en ensidig bild av fenomenet ”krigsvåld.” Forskare har uppmärksammat betydelsen av efterkrigsberättelser, men de har inte uppmärksammat berättelser om krigsvåld, eller analyserat berättelserna om krigsvåld som en produkt av mellanmänsklig interaktion. Denna artikel försöker fylla denna kunskapslucka genom att anPrevious research on violence during the war in Bosnia and Herzegovina presents a one-sided picture of the phenomenon ”war violence.” Researchers have emphasized the importance of narratives but they have not focused on stories about war violence, nor have they analyzed the stories of war violence being a product of interpersonal interaction. This article tries to fill this knowledge gap by analyz