Streptococcus pyogenes, or Group A Streptococcus, is an exclusively human pathogen that causes a wide variety of diseases ranging from mild throat and skin infections to severe invasive disease. The pathogenesis of S. pyogenes infection has been extensively studied, but the pathophysiology, especially of the more severe infections, is still somewhat elusive. One key feature of S. pyogenes is th

Considerable debate has focused on whether sampling of molecular dynamics trajectories restrained by crystallographic data can be used to develop realistic ensemble models for proteins in their natural, solution state. For the SARS-CoV-2 main protease, Mpro, we evaluated agreement between solution residual dipolar couplings (RDCs) and various recently reported multi-conformer and dynamic-ensemble

The use of metal and metal oxide nanomaterials (NMs) is experiencing a significant surge in popularity due to their distinctive structures and properties, making them highly attractive for a wide range of applications. This increases the risks of their potential negative impact on organisms if dispersed into the environment. Information about their behavior and transformation upon environmental in

Denna avhandling fokuserar på svensk extraktivism i Sápmi/Norrbotten genom att studera den planerade järnmalmsgruvan i Gállok/Kallak och den gröna omställningen inom stålproduktionen. Huvudsyftet är att förstå tilltron till resursutvinning som ett sätt att nå en lycklig, grön, och god framtid. Med utgångspunkt i psykoanalys läser jag resursutvinning som ett begärsobjekt som människor söker sig tilThis dissertation deals with Swedish extractivism in Sápmi through the examples of a planned iron ore mine in Gállok/Kallak and the hydrogen-based steel transition. The main aim is to understand the trust that is placed in extraction as a means to arrive at a happy, prosperous, green future. Drawing on Lacanian psychoanalysis and Sara Ahmed’s notion of the promise of happiness, I suggest that extr

The Central Asian region, with its young and industrious population, abundant natural resources, and rich history, has all the potential for success. In this context, countries in the region are implementing policies to attract foreign investment for the development of their economies. This report serves as a guide to the socio-economic and political-legal aspects of two major countries in the reg

The element silicon is everywhere! In fact, silicon is the second most abundant element in Earth’s crust. Silicon in rocks and minerals breaks down and is transported from rivers and streams into the world’s oceans. Many marine organisms need silicon as it is a crucial nutrient to build their skeletons. Silicon eventually reaches the seafloor, but its journey into the abyss is not straightforward

Brain tissue of Alzheimer’s disease patients invariably contains deposits of insoluble, fibrillar aggregates of peptide fragments of the amyloid precursor protein (APP), typically 40 or 42 residues in length and referred to as Aβ40 and Aβ42. However, it remains unclear whether these fibrils or oligomers constitute the toxic species. Depending on sample conditions, oligomers can form in a few secon

Protein transport across the cytoplasmic membrane of bacterial cells is mediated by either the general secretion (Sec) system or the twin-arginine translocase (Tat). The Tat machinery exports folded and cofactor-containing proteins from the cytoplasm to the periplasm by using the transmembrane proton motive force as a source of energy. The Tat apparatus apparently senses the folded state of its pr

Phosphate plays a crucial role in biology because of the stability of the phosphate ester bond. To overcome this inherent stability, enzymes that catalyze phosphoryl transfer reactions achieve enormous rate accelerations to operate on biologically relevant time scales, and the mechanisms that underpin catalysis have been the subject of extensive debate. In an archetypal system, β-phosphoglucomutas

Phosphorus acquisition is critical for life. In low phosphate conditions, some species of bacteria have evolved mechanisms to import reduced phosphorus compounds, such as phosphite and hypophosphite, as alternative phosphorus sources. Uptake is facilitated by high-affinity periplasmic binding proteins (PBPs) that bind cargo in the periplasm and shuttle it to an ATP-binding cassette (ABC)-transport

Lysostaphin is a bacteriolytic enzyme targeting peptidoglycan, the essential component of the bacterial cell envelope. It displays a very potent and specific activity toward staphylococci, including methicillin-resistant Staphylococcus aureus. Lysostaphin causes rapid cell lysis and disrupts biofilms, and is therefore a therapeutic agent of choice to eradicate staphylococcal infections. The C-term

Enzyme regulation is vital for metabolic adaptability in living systems. Fine control of enzyme activity is often delivered through post-translational mechanisms, such as allostery or allokairy. β-phosphoglucomutase (βPGM) from Lactococcus lactis is a phosphoryl transfer enzyme required for complete catabolism of trehalose and maltose, through the isomerisation of β-glucose 1-phosphate to glucose

The popularity of digital gaming among older adults is on the rise, necessitating a deeper understanding of this phenomenon. Drawing upon the concepts and theoretical perspectives in domestication theory, actor network theory, and media engagement theory, we explored the digital gameplay experiences of older adults in China’s sociocultural contexts. We conducted in-depth interviews with 12 adults

Denna rapport sammanställer och sammanfattar arbetsmaterial i förhållande tillarbetsgruppens fyra frågeställningar och syftar till att ge underlag för verksamheternas fortsatta diskussioner. På så sätt följer den inte gängse utformning för en FoU-rapport och gör inte heller anspråk på att rapportera några färdiga slutsatser. Analyserna kommer att bearbetas vidare på olika sätt; praktiskt i verksam