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The pinch-off dynamics during hydrogen bubble formation was experimentally investigated in a cross-junction microchannel. A binarization interface recognizing and key frame tracking method was established. By analyzing the breakup dynamics through spatial and time domains, the effects of interfacial tension and viscosity on hydrogen bubble pinch-off were revealed. A transitional stage between a li
We have entered a monumental era in terms of realizing the impact of biodiversity loss on our everyday lives. We suffer from the consequences of biodiversity loss due to overexploitation of natural resources as we continue failing to restore biodiversity. One of the major consequences of biodiversity loss is the emergence of global pandemics. We are in urgent need of realizing the full potential o
Background: Proinflammatory mechanisms are implicated in pain states. Recent research indicates that patients with osteoarthritis (OA) with signs of central sensitization exhibit elevated cerebrospinal fluid (CSF) levels of interferon gamma-induced protein 10 (IP-10), Fms-related tyrosine kinase 1 (Flt-1), and monocyte chemoattractant protein 1 (MCP-1).Methods: The current prospective cohort study
Background and objectives: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there is limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. Study I aimed to investigate whether there are coherent changes in CSF inflammation associated with central sensitization (CS), and to evaluate po
Laryngeal papilloma (LP) is a rare benign disease, caused by recurrent multisite papillomas that are referred to as recurrent respiratory papillomatosis (RRP). RRP is caused primarily by two types of human papillomavirus (HPV): HPV6 and HPV11. The immune dysregulation within the microenvironment of the lesions has been shown to likely play a role in the development of RRP. The present study aimed
Objective: Cognitive workload monitoring (CWM) can enhance human-machine interaction by supporting task execution assistance considering the operators cognitive state. Therefore, we propose a machine learning design methodology and a data processing strategy to enable CWM on resource-constrained wearable devices. Methods: Our CWM solution is built upon edge computing on a simple wearable system, w
Opposition to immigration has featured prominently in the “cultural backlash” to globalization in Western nations and was a key determinant of Britain’s Brexit referendum. In this article, we draw on theories of intergroup threat to examine the effect of “right-wing authoritarianism” on immigration attitudes in the UK. Previous research suggests that cultural aspects of immigration are especially
This chapter visits some of the fundamental concepts from platform economics, network effects, and network externalities. Further on, it discusses definitions of two-sided and multi-sided markets, how they are treated as business models. These concepts are further compared to the concept service ecosystem. A case of a payment service provider whose business model contributes to the growth of e-com
Background: Septic arthritis (SA) is a serious condition in dogs that requires a prompt diagnosis and treatment to minimize long-term joint pathology. Although bacterial detection in synovial fluid (SF) through culture or cytology is often performed to confirm diagnosis, the sensitivity of these tests is low. The need for a reliable diagnostic tool to confirm the presence of bacteria in SF in huma
Dion–Jacobson (DJ)-type 2D halide perovskites present superior environmental stability and a narrower bandgap, yet a contradiction between charge transport and stability remains to be resolved. Herein, it is shown that both symmetry and substitution of the organic spacer in DJ perovskites synergistically direct the narrow interlayer spacing, staggered spacer alignment, and regular phase arrangemen
Background: Influenza-like illness (ILI) and Acute Respiratory Infections (ARI) are a considerable health problem in Europe. Most diagnoses are made by family physicians (FPs) and based on symptoms and clinical signs rather than on diagnostic testing. The International Classification of Primary Care (ICPC) advocates that FPs record patients’ ‘Reasons for Encounters’ (RfEs) as they are presented to
Ultrasound safety is of particular importance in fetal and neonatal scanning. Fetal tissues are vulnerable and often still developing, the scanning depth may be low, and potential biological effects have been insufficiently investigated. On the other hand, the clinical benefit may be considerable. The perinatal period is probably less vulnerable than the first and second trimesters of pregnancy, a
Achilles tendons are mechanosensitive, and their complex hierarchical structure is in part the result of the mechanical stimulation conveyed by the muscles. To fully understand how their microstructure responds to mechanical loading a non-invasive approach for 3D high resolution imaging suitable for soft tissue is required. Here we propose a protocol that can capture the complex 3D organization of
Background: During COVID-19 pandemic, physiotherapy lecturers faced the challenge of rapidly shifting from face-to-face to online education. This retrospective case-control study aims to compare students’ satisfaction and performances shown in an online course to a control group of students who underwent the same course delivered face-to-face in the previous five years. Methods: Between March and
Two methods of setting clocks to show correct time during the 17th century by French Jesuits in China are investigated and their computations and accuracy are analysed. These methods were used to rectify the clocks used for timings of eclipses of the Galilean moons or for lunar eclipses that in turn were used to determine geographical longitudes by Jesuit missionaries in Siam and China. It is f
Background: Knee pain is studied mostly in older age groups, although in young adults it may be an indicator of future impaired musculoskeletal health. Therefore, the aim of this study was to examine the longitudinal association between knee pain and thigh muscle strength in young adult women and to explore the associations between muscle strength, body composition, physical activity and knee pain
Asthma exacerbations are commonly triggered by rhinovirus infections. Viruses can activate the NFκB pathway resulting in airway inflammation and increased Th2 cytokine expression. NFκB signaling is also involved in early activation of IFNβ, which is a central mediator of antiviral responses to rhinovirus infection. Using a mouse model, this study tests our hypothesis that NFκB signaling is involve
