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Conditional estimation in two-stage adaptive designs

We consider conditional estimation in two-stage sample size adjustable designs and the consequent bias. More specifically, we consider a design which permits raising the sample size when interim results look rather promising, and which retains the originally planned sample size when results look very promising. The estimation procedures reported comprise the unconditional maximum likelihood, the c

Molecular mechanisms underlying lineage bias in aging hematopoiesis

Although hematopoietic stem cells (HSCs) have traditionally been thought to possess the ability to give rise to all the mature cell types in the hematopoietic system, this conception of hematopoiesis was based on evaluation of hematopoietic output from large numbers of HSCs using transplantation models. More recent studies evaluating HSCs at the clonal or near-clonal level, both in transplantation

The association between gaba-modulators and clostridium difficile infection - A matched retrospective case-control study

Objective Recently, metabolomics studies have suggested that the neurotransmitter ã-amino butyric acid (GABA) may modulate C. difficile infection (CDI) pathogenesis. In the present study, we investigated the association between GABA-modulating pharmaceuticals and CDI development. Methods In July-December 2013, we performed a matched, retrospective case-control study in Skåne county, Sweden, to ass

A Kind of Friend (text)

The text "A Kind of Friend" is a written abstract about the video essay with the sam name

Learning Tools with Pedagogical Standards

E-learning tools are becoming more advanced as Web 2.0 and the participatory Internet evolves. This paper discusses the need for a concrete pedagogical foundation on how to best use E-Learning tools. By examining some of the tools that are available now, we discuss what is suitable and what could be inappropriate. The significance of the traditional didactic triangle is reviewed and a new twist mi

Trio con Forza, works for flute, viola and guitar

Works for flute viola and guitar performed by Terje Thiwång, flute, Torbjörn Helander, viola and Stefan Östersjö guitar. Music by Kent Olofsson, Kay Holmquist, Rolf Martinsson, André Chini and Fredrik Österling