L-DOPA-induced dyskinesia (abnormal involuntary movements) is one of the most debilitating complications of chron-ic L-DOPA pharmacotherapy in Parkinson's disease. It is generally agreed that dyskinesia arises as a consequence of pulsatile dopamine-receptor stimulation in the brain, causing downstream changes in genes and proteins. Advance in our understanding of such changes is critically depende

The bacteriocin, sakacin P was produced by the bacteriocin-producing strain Lactobacillus sakei CCUG 42687 at 20 degrees C without pH control. The bacteriocin was captured directly from the fermentation broth using macroporous octyl- and phenyl-monolith columns. The large size of the interconnected macropores (up to 100 mu m) in the macroporous monolith allowed for direct fermentation broth proces

Leukotriene B-4 (LTB4) is a potent pro-inflammatory mediator that has been implicated in the pathogenesis of multiple diseases, including psoriasis, inflammatory bowel disease, multiple sclerosis and asthma. As a method to decrease the level of LTB4 and possibly identify novel treatments, inhibitors of the LTB4 biosynthetic enzyme, leukotriene A(4) hydrolase (LTA(4)-h), have been explored. Here we

Neoglycoconjugates were prepared from mannan isolated from yeast Saccharomyces cerevisiae and activated by periodate oxidation to create aldehyde groups. Various degrees of oxidation introduced 11-28 aldehyde groups per mannan molecule and simultaneously resulted in a molar mass decrease from 46 to 44.5-31 kDa. The activated mannans were subsequently conjugated with bovine serum albumin forming ne

Clusterin is suggested to be involved in the pathogenesis of Alzheimer's disease. Clusterin expression is increased in brain tissue in affected regions of Alzheimer patients, and intense clusterin staining is found in both senile plaques and in neuronal and glia cells. In contrast, the cerebrospinal fluid level of clusterin in Alzheimer patients has, thus far, been found unchanged. Clusterin is a

The increased concern for the security of the oil supply and the negative impact of fossil fuels on the environment, particularly greenhouse gas emissions, has put pressure on society to find renewable fuel alternatives. The most common renewable fuel today is ethanol produced from sugar or grain (starch); however, this raw material base will not be sufficient. Consequently, future large-scale use

Cross-sectional survey data on Swedish adolescents aged 12 - 18 was used to analyse perceived risks of smoking-related lung cancer, the determinants of these risk perceptions, and how these perceptions related to smoking behaviour. Three major conclusions were drawn: ( 1) that both smokers and non-smokers overestimated the risks of lung cancer, ( 2) that these risk perceptions fell substantially w

A new computerized dark adaptometer was developed achieving a 50% reduction of examination time. Functions were implemented for the recording of sustained attention (ie, the capacity to maintain focus and alertness over time (vigilance)). Eighteen healthy subjects were tested three times each on different days. All tests were analyzed for parameters analogous to measurements derived from continuou

OBJECTIVE: In acute respiratory distress syndrome, the relationships between changes in the elastic behavior of the respiratory system and biological markers of extra-cellular matrix or surfactant turn-over could give some insights into its pathophysiological determinants. DESIGN AND MEASUREMENTS: In 17 patients with acute respiratory distress syndrome, we assessed the relationship between chord c

We investigate the lowest state of a rotating, weakly interacting Bose-Einstein condensate trapped in a harmonic confining potential that is driven by an infinitesimally asymmetric perturbation. Although in an axially symmetric confining potential the gas has an axially symmetric single-particle density distribution, we show that in the presence of the small asymmetric perturbation its lowest stat

In order to better assess the role of agriculture within the global climate-vegetation system, we present a model of the managed planetary land surface, Lund-Potsdam-Jena managed Land (LPJmL), which simulates biophysical and biogeochemical processes as well as productivity and yield of the most important crops worldwide, using a concept of crop functional types (CFTs). Based on the LPJ-Dynamic Glo

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