Elevated basal insulin secretion under fasting conditions together with insufficient stimulated insulin release is an important hallmark of type 2 diabetes, but the mechanisms controlling basal insulin secretion remain unclear. Membrane rafts exist in pancreatic islet cells and spatially organize membrane ion channels and proteins controlling exocytosis, which may contribute to the regulation of i

Cerebrospinal fluid (CSF) tau (total tau, T-tau), neurofilament light (NFL), and neurogranin (Ng) are potential biomarkers for neurodegeneration in Alzheimer's disease (AD). It is unknown whether these biomarkers provide similar or complementary information in AD. We examined 93 patients with AD, 187 patients with mild cognitive impairment, and 109 controls. T-tau, Ng, and NFL were all predictors

Human cystatin C, a member of the cysteine proteinaseinhibitory family, is produced by all nucleated cells and has important roles in regulating natural immunity. Nematode homologs to human cystatin C have been shown to have anti-inflammatory effects on monocytes and to reduce colitis in mice. In Crohn’s disease, pathogenic activated monocytes help drive inflammatory processes via the release of p

The Cross-Wavy primary surface heat exchanger is one of the most promising candidates for microturbine recuperators. In this paper, naphthalene sublimation experiments are performed for Cross-Wavy channels in a wind tunnel. The experimental results indicate that the entrance region has a small effect on the unit-averaged heat transfer coefficient of whole Cross-Wavy channels. Correlations of Nusse

This paper provides a regional, empirical analysis of policy portfolios that aim to contribute towards a ‘Green Energy Economy’ (GEE) transformation. Taking green economy policies and related indicators as the analytical framework, the study examines (i) the composition of policy portfolios promoting low-carbon energy technologies, (ii) short-term trends related to the GEE, (iii) long-term empiric

Here, we first present a follow-up to a previous work by our group on the problematic of molecular dynamics simulations of intrinsically disordered proteins (IDPs) [Henriques et al. J. Chem. Theory Comput. 2015, 11, 3420−3431], using the recently developed TIP4P-D water model. When used in conjunction with the standard AMBER ff99SB-ILDN force field and applied to the simulation of Histatin 5, our

AbstractCardiac resynchronization therapy (CRT) has improved quality of life and survival in select heart faillure patients, however 30-40% of patients do not show objective benefit from the treatment. At the same time there is little evidence about the long term effect of changes in medical treatment in these patients. Several factors have been examined to improve the response rate in the ”non-re

Abstract Background: Cardiac resynchronization therapy (CRT) is effective, but only 60-70% of patients benefit from the therapy. Despite numerous implantations, identification of predictive factors for response is still a challenge. We sought to assess the correlation of echocardiographic and clinical response to baseline demographics in relation to change in NT-proBNP levels at 6 months. Methods:

This article discusses the enigmatic logion 27 in the Gospel of Thomas. It argues that preconceived notions of the text being “Gnostic” have affected previous interpreta- tions of how the Sabbath is portrayed in logion 27. A discussion follows concerning the many different interpretations of the elusive second part of the logion and the phrase σαββατίσητε τὸ σάββατον/ⲉⲓⲣⲉ ⲙ̄ⲡⲥⲁⲙⲃⲁⲧⲟⲛ ⲛ̄ⲥⲁⲃⲃⲁⲧⲟⲛ. T

In this article the notion that women retained a special position among ”Gnostics”, compared the surrounding context, is questioned. It is pointed out that there are no necessary correlation between myth and social reality. Finally, it is argued that proto-orthodox portrayals of “Gnostics” as favoring women should chiefly be under-stood as a polemical technique meant to discredit ones opponents.

In this paper we study symmetries in polynomial equation systems and how they can be integrated into the action matrix method. The main contribution is a generalization of the partial p-fold symmetry and we provide new theoretical insights as to why these methods work. We show several examples of how to use this symmetry to construct more compact polynomial solvers. As a second contribution we pre

BACKGROUND: Both persons with intellectual disability (ID) and persons with dementia have high disease burdens, and consequently also high health care needs. As life expectancy increases for persons with ID, the group of persons with the dual diagnosis of ID and dementia will become larger.METHOD: Through national registries, we identified 7936 persons who had received support directed to persons

Burkitt lymphoma (BL) is a rare, aggressive disorder constituting 1% of all non-Hodgkin lymphoma. Diffuse large B-cell lymphoma (DLBCL) is more common, accounting for 30% of malignant lymphoma. Standard treatment for adult BL and for certain subgroups of patients with DLBCL remains to be defined due to paucity of randomised trials performed. The focus in this thesis lies on the effect of prognosti

A third of Sweden's two million single-family houses were built in the period 1961-1980, and many of them are in need of renovation. These houses have a high energy use and are in technical terms fairly homogenous. This investigation evaluates the theoretical energy savings potential of renovating houses from this period. Four reference houses were selected and simulated using common renovation me

This work describes the preparation and investigation of molecularly imprinted polymer (MIP) microgels (MGs) stabilized Pickering emulsions (PE) for their ability to catalyze the formation of disulfide bonds in peptides at the O/W interface. The MIP MGs were synthesized via precipitation polymerization and a programmed initiator change strategy. The MIP MGs were characterized using DLS analysis, S

Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. The latter include metabolic dysfunction and psychiatric deficits, such as depression and anxiety, are often observed in patients andanimal models of HD

Multiple studies have described associations between infiltrating immune cells and prognosis in cancer; however, the clinical relevance has most often been attributed to the T-cell linage. This study aimed to further investigate the clinicopathological correlates and prognostic impact of B cell and plasma cell infiltration in CRC. Immunohistochemical expression of CD20, CD138 and immunoglobulin ka