Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer cell survival. We now demonstrate that the PDZ-binding motif of Claudin-2 is necessary for anchorage-independent growth of cancer cells and is required for liver metastasis. Several PDZ domain-containing proteins were identified that interact with the PDZ-binding motif of Claudin-2 in liver metastatic breast can

Aridity and seasonality of precipitation are characteristics of the highland region in Bolivia. Groundwater becomes an important and safe source of water when surficial bodies are intermittent and affected by natural and anthropogenic contamination. Decades of exploitation of the Challapampa aquifer, combined with lack of information required to understand the groundwater circulation, represent a

Chronic lymphocytic leukemia (CLL) patients with differential somatic hypermutation status of the immunoglobulin heavy variable genes, namely mutated or unmutated, display fundamental clinico-biological differences. Considering this, we assessed prognosis separately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015 patients, hypothesizing that the relative significance of relevant indicator

The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive fact

PurposeQuantitative MRI (qMRI) yields reproducible “maps” of physiological and/or biophysical tissue parameters. These spatially resolved metrics are mainly used in clinical imaging research for cross-sectional and longitudinal studies. The field of qMRI has considerable expanded during the past two decades. Rather than focusing on particular methods, this talk highlights general concepts of accur

Music in different forms is significant in young people’s lives. Due to the media revolution in our modern society, children of today learn a lot about music on their own by taking part in an increasing production of musical cultures. In this paper different forms of play is applied as a way to reach a deeper understanding of children’s creative music making. This article describes a 2-year empiri

In the complex OR environment, perioperative team members need to practice communication and teamwork to ensure safe, high-qualitycare. A lack of collaboration among professionals in the OR during surgery results in inefficiency, increased tension, and suboptimal patient care. The purpose of this study was to determine how nurse anesthetists and OR nurses experienced their work in the OR. We used

The starting point for this inductive study is to determine, through a search of studies, what critical viewpoints in terms of research are delivered, based on experiences, observations and evaluation, concerning the Bologna Process over time? The aim is to present a description using a thematic analysis based on data from 38 papers (2004–2016) that reveal the critical reasoning behind the researc

Cities all over the world are being densified in the quest for sustainable urban development. Whether or not this is a viable strategy is an ongoing debate, but as densifying cities face certain challenges, they can learn from already dense cities, where interactions between interior and exterior space are explicit. This paper takes Hong Kong as a model for the densifying city to focus on three le

BackgroundThe purpose of this study was to contribute to knowledge about what is regarded as an appropriate governance model in welfare markets in healthcare, from the perspective of government. The study draws on a framework about governance in healthcare systems as a continuous process of priority setting, monitoring and accountability. It relates to various dimensions of management controls; a BackgroundThe purpose of this study was to contribute to knowledge about what is regarded as an appropriate governance model in welfare markets in healthcare, from the perspective of government. The study draws on a framework about governance in healthcare systems as a continuous process of priority setting, monitoring and accountability. It relates to various dimensions of management controls; a

Sedan slutet av 1970-talet har Kina upplevt en anmärkningsvärd socioekonomisk utveckling. Tendensen till marknadifiering och modernisering försvagade kulturellt rotade livsstilar och allt fler etniska minoritetsgrupper i Kina har börjat betrakta traditionell kultur som irrelevant för deras försörjning och framtid samt i viss utsträckning också har börjat ta avstånd från dessa. Detta utgör ett hot Since the late 1970s, China has experienced remarkable socioeconomic development. The trend towards marketisation and modernisation overturned culturally-rooted lifestyles, and more and more ethnic minorities in China have started to regard their traditional cultures as irrelevant to their livelihoods and future and chosen to move away from them. This poses a threat to the idea of ethnic diversity

Background: Studies assessing institutional performance regarding quality of care are frequently performed using single-level statistical analyses investigating differences between provider averages of various quality indicators. However, such analyses are insufficient as they do not consider patients' heterogeneity around those averages. Hence, we apply a multilevel analysis of individual-patient

DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (N ¼ 1,595) were used to build genetic models to predic