Background The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radio

Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal c

The Oak of Mambre presents an inner world of sound exploration, whose strands are woven through ancient cultures and traditions. Mambre is a birthplace, itself, literal and ideal. Compressions and rarefactions tell two stories; of Abram and Mambre, of survival and an heir.The Oak of Mambre begins where the reality and existence of a tone becomes manifest. Here we are looking at the sub-particulate

The objective of this study is to estimate the number of deaths attributable to cardiovascular diseases and diet-related cancers that could be prevented or delayed in the Nordic countries, i.e., Sweden, Denmark, Finland, Norway, and Iceland, if adults adhere to the Nordic Nutrition Recommendations (NNR). A sex- and age-group specific epidemiological macro-simulation model was used to estimate the

The requirements on increasing functionality, quality, and, customisation, while reducing cost has lead to the introduction of an architecture centred development process for electronic systems at Volvo Cars. This process enables better control of system integration and achieving non-functional requirements, such as reusability, understandability, etc. The result of the process is a reference arch

In the early days of vehicle engineering, the car was designed top-down. Most design decisions were taken bearing the complete vehicle in mind. As sub-systems have become more complex, and also deeply interlinked, the width of the problem has become impossible for one engineer to understand in all aspects. To be able to cope with this, vehicle manufacturers have created stable partitionings of the

This paper presents a previously unreported method of laryngeal vocal sound production that is capable of producing pitches even higher than the whistle register (M3). Colloquially known as the glottal whistle (here referred to as M4), this method has a wider range than M3 and features frequent instances of biphonation, which is of interest for those involved with contemporary and improvised music

This paper suggests that rhythmic notational practice seen in complex music adhere to the principle that the number of beams/flags of any note is dependent upon the number of iterations per temporal unit. In the first in- stance this may seem obvious, since this principle forms the basis of rational rhythmic notation in music. However, with music featuring nested tuplets of two levels or more, an

INTRODUCTION: Breast hypertrophy is a condition associated with physical, psychological, and psychosocial problems. The primary aims of this study were to determine the impact of breast hypertrophy and the effects of breast reduction, performed on the basis of well-described inclusion criteria, on general and breast-related health, using both general and diagnosis-specific validated questionnaires

The purpose of this review was to evaluate systematically all published and unpublished research concerning culture and medical procedural pain in children. Databases, reference lists, and electronic list servers were searched as data sources. Fifteen studies met the inclusion criteria. Most studies (80%) were conducted solely in the United States comparing Caucasian American groups to other local

Comparing complication rates between centres is difficult due to the lack of unanimous criteria regarding what adverse events should be defined as complications and how these events should be compiled. This study analysed all adverse events in a cohort of craniofacial (CF) operations over a 10-year period and applied three different scales (Clavien-Dindo, Leeds and Oxford) for systematic compariso

Culture is commonly regarded as a factor in pain behaviour and experience, but the meaning of the term is often unclear. There is little evidence that pain perception is modified by cultural or ethnic factors, but pain expression by children and interpretation by caregivers may be affected by the culture of the patient or the caregiver. The present paper examines some of the research regarding cul

Distraction has shown to be a helpful pain intervention for children; however, few investigations have studied the effectiveness of this method with adolescents. The aim of this study was to evaluate the usefulness of an easy and practical musical distraction in reducing adolescents' immunization pain. Furthermore, to examine whether musical distraction techniques (with or without headphones) used

The aim of the study was to examine the role culture plays in caregiver’s pain-related parent behaviors. This study used a cross-cultural survey design with a convenience sample of caregivers of 6-12-year-old children (N = 547) living in Canada (n = 183), Iceland (n = 184), or Thailand (n = 180). A team-translation approach included psychometric assessment and confirmatory factor analysis, ensurin