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The illicit trafficking of cultural heritage represents a significant global challenge, exacerbated by digital technologies that facilitate unauthorised trade while offering new protection opportunities. The ANCHISE project addresses these challenges through a suite of six innovative, complementary tools designed to enhance the detection, prevention, and investigation of cultural property traffick
South America’s major montane systems (Andes, Pantepui, Atlantic Forest) host many endemic lineages, including some that are phylogenetically related across these systems yet highly divergent from lineages in the intervening lowlands. This pattern likely reflects historical vicariance, dispersals, and extinctions, but the spatiotemporal context of these events relative to environmental changes and
In univariate spatial stochastic models, parameter space dimension is reduced through structural models with a known adjacency matrix. This structural reduction is also applied in multivariate spatial settings, where matrix-valued observations represent locations along one coordinate and multivariate variables along the other. However, such reduction often goes too far, omitting parameters that ca
Microglia exhibit targeted responses to different stimuli, including lipids, which can differ depending on the environmental conditions they encounter. These responses involve inflammatory mediators and are crucial for maintaining brain homeostasis. This study investigated whether inflammatory, metabolic, and phagocytic responses of microglia to the saturated fatty acid palmitate depend on extrace
Lysine is an essential amino acid with insulinotropic effects in humans. In vitro, it enhances glucose-stimulated insulin secretion (GSIS) in β-cell lines and rodent islets. While lysine is thought to act via membrane depolarization similar to arginine, the role of its intracellular metabolism in β-cell function remains unexplored. Here, we show that lysine acutely potentiates GSIS and that genes
Purpose To evaluate the added value of 7 Tesla (T) magnetic resonance imaging (MRI) in the presurgical assessment of patients with temporal lobe epilepsy (TLE), considering its overall impact on clinical decision-making, including both MRI-positive and MRI-negative cases, and its timing during the evaluation process. Methods Sixty-one patients with drug-resistant TLE, enrolled in this study underw
Poultry industry worldwide: Newcastle Disease (ND) is highly contagious poultry viral disease posed a major threat to the poultry industry due to millions of deaths worldwide. Newcastle Disease Virus (NDV) cause recurrent epidemics due to its rapid genomic evolution. In this study, we developed an in silico vaccine against all NDV strains using matrix protein. A reverse vaccinology approach was em
The laminar burning velocity (SL) of methane (CH4), the primary constituent of natural gas, is a key combustion property essential for validating combustion kinetic models. The present study focuses on the CH4 SL at the very rich side of flames, where the available experimental data are scarce with highly dispersed measurement conditions, and data projection was carried out to overcome the difficu
This study explores sustainable energy renovation strategies for a congregation building in southern Sweden using a parametric optimization approach to balance passive and active measures. Passive measures include envelope and window improvements and leakage control, while active measures involve photovoltaic integration and ventilation enhancements. The renovation aims to optimize energy use, the
Digitalization holds significant potential to improve the efficiency, flexibility, and sustainability of District Heating (DH) systems. However, the transition toward digitalized DH is often constrained by challenges beyond technology—such as regulatory uncertainty, unclear business models, fragmented organizational capacity, and misaligned stakeholder incentives. This paper offers a comparative,
Non-exhaust emissions from the wear of brakes, tyres, and roads have become an increasing concern in recent years, already surpassing exhaust emissions by mass in many countries. However, there is a lack of studies in the scientific literature on test methods that include both real tyre and road materials. This is crucial for accurately replicating the tribological mechanisms and resulting emissio
BACKGROUND: Limbic-predominant age-related TDP-43 encephalopathy (LATE) clinically mimics and often co-occurs with Alzheimer's disease (AD). Expert consensus criteria have been proposed for the LATE clinical diagnosis, integrating clinical and radiological features, and AD biomarkers. Here, we applied the newly proposed criteria in a tertiary memory clinic population. METHOD: We included participa
Aims Academic journals are essential for advancing knowledge, yet gender disparities in orthopaedic authorship persist. While most previous studies focus authorship trends on mainly North American journals, this study analyzes gender distribution among primary and senior authors, along with the geographical origins of articles, in three orthopaedic journals based in Europe and North America. Metho
Background: Agroecology integrates ecological agricultural production with community self-reliance, deeply rooted in indigenous knowledge. This study investigates how and why women in Zimbabwe contribute to seed preservation in agroecology, and what challenges they face in sustaining traditional seed systems. Using a qualitative approach combining focus group discussions, semi-structured interview
Extracellular vesicles (EVs) in biofluids are heterogeneous in origin, surface protein expression, and biomolecular cargo. Isolation of specific EV subpopulations may enable studies of biomarkers originating from specific cell phenotypes and disease states. Acoustic trapping is a rapid, automatable EV isolation technique requiring minimal sample preprocessing; however, it lacks the specificity nee
An analytical model to describe the time-domain reflectance Raman signal in a two-layer diffusive medium was developed. The accuracy of the model is verified by comparison with the results of Monte Carlo simulations.
Single-cell technologies have transformed our understanding of cellular heterogeneity through multimodal data acquisition. However, robust cell alignment remains a major challenge for data integration and harmonization, including batch correction, label transfer, and multi-omics integration. Many existing methods constrain alignment based on rigid feature-wise distance metrics, limiting their abil
