The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75–78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on mult

IntroductionIn this follow-up study, cerebral microvascular formations termed ‘raspberries’ were quantified according to cerebral atherosclerosis (C-ASCL) and acute circulatory failure (ACF). We also examined the regional distribution of raspberries throughout the brain.Materials and methodsThe study population consisted of adult individuals who had undergone a diagnostic neuropathological autopsy

Using patent data for a panel sample of European companies between 1995 and 2016 we explore whether the inventive success in Artificial Intelligence (AI) is related to earlier firms’ innovation in the area of Information and Communication Technology (ICT), and identify which company characteristics and external factors shape this performance. We show that AI innovation presents strong dynamic retu

In the present work, we have generated a new second-nearest neighbour modified embedded atom method potential (2NN-MEAM) for the W–P system to investigate the impact of P impurity segregation on the strength of symmetric ⟨110⟩ tilt coincident site lattice grain boundaries (GBs) in tungsten. By incorporating the impurity- induced reduction of the work of separation in the fitting strategy, we have

En femtedel av Sveriges befolkning är barn i åldrarna 0–17 år, totalt drygt 1,9 miljoner. Barndomen är den socialiseringsprocess där barn utvecklas till unika individer och blir en del av samhället. Kulturella sammanhang påverkar barns känsla av samhörighet och av att höra hemma någonstans. Synen på barn och hur de behandlas, också när de är sjuka, påverkas därmed av ett flertal historiska, kultur

The ferroelectric (FE)-antiferroelectric (AFE) transition in Hf1-xZrxO2 (HZO) is for the first time shown in a metal-ferroelectric-semiconductor (MFS) stack based on the III-V material InAs. As InAs displays excellent electron mobility and a narrow band gap, the integration of ferroelectric thin films for nonvolatile operations is highly relevant for future electronic devices and motivates further

Sweden is renowned for its centralized wage bargaining system, which has been studied for decades from the point of view of inflation, wage differentials and unemployment. A coordinated system in place since 1997 has been compared to the centralized system of the postwar era, while other scholars have pointed to differences in how the institutions work in practice. This paper studies media coverag

This article explores the possibilities of using digital methods to study religion and religious change in contemporary societies. It argues that despite considerable developments in which analogue data has been converted into digital forms and new digital methods have been developed, these are rarely used in sociology of religion. The article illustrates how new digital methods can complement mor

This article is the concluding essay of the Western and Northern Europe volume of Edinburgh University Press's series on Global Christianity.

This study deploys a critical approach to big data analytics to gauge the tentative contours of data voids in Google searches that reflect extreme-right dynamics of exclusion in the aftermath of the 2015 humanitarian crisis in Europe. The study adds complexity to the analysis of data voids, expanding the framework of investigation outside the USA context by concentrating on Germany and Sweden. Bui