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Here you fins video presentations of Walleberg Researchers and their research. Agnete Kirkeby – Repairing the brain with stem cells Anja Meissner - New treatments for cardiovascular diseases Darcy Wagner – Developing therapies for patients with lung diseases Filipe Pereira – Reprogramming cells paving the way for new cancer treatment Iben Lundgaard – The cleaning system of the brain Joao Duarte –
https://www.wcmm.lu.se/wallenberg-researcher-videos - 2025-08-15
Here you’ll find out more about the events in and around the WCMM Centre. Get inspired of what’s going on right now or later on!
https://www.wcmm.lu.se/whats - 2025-08-15
From cells to cities, from the smallest building blocks to the secrets behind our bodies in health and disease. Lund is a thriving research center tackling all kinds of fundamental questions, most of which can be hard to access or understand. Until now! WCMM Lund presents: the ScienceBrew. Popular science talks by researchers from Lund University. A collection of 10 minute “chalk-talks” around a c
https://www.wcmm.lu.se/whats/wcmm-sciencebrew - 2025-08-15
WCMM Fellow | Human Neural Developmental Biology Our research The Kirkeby Lab studies the factors involved in human neural subtype specification in order to enable production of specific neurons for understanding and treating neurological diseases. We use stem cells to produce specific subtypes of human neurons. Focus is to develop novel stem cell transplantation therapies for neurodegenerative di
https://www.wcmm.lu.se/agnete-kirkeby - 2025-08-15
For many double stranded (ds) DNA viruses the viral genome is actively packaged into the virus capsid by a powerful molecular motor. This results in an energetically unfavorable state of the packaged genome, creating tens of atmospheres internal pressure inside the virion. Using a new calorimetric assay to determine the activation energy barriers associated with genome loss in response to elevated
https://www.virus-biophysics.lu.se/covers-highlights-0 - 2025-08-15
For many double stranded (ds) DNA viruses the viral genome is actively packaged into the virus capsid by a powerful molecular motor. This results in an energetically unfavorable state of the packaged genome, creating tens of atmospheres internal pressure inside the virion. Using a new calorimetric assay to determine the activation energy barriers associated with genome loss in response to elevate
https://www.virus-biophysics.lu.se/covers-movies-and-highlights - 2025-08-15
ALEX EVILEVITCH RESEARCH GROUP We are always interested in reviewing applications from MSc students, prospective PhD students and postdocs. Project description Herpesviruses are a leading cause of human viral disease. Herpesviruses consist of a double-stranded DNA genome contained within a protein shell, termed the capsid, that is surrounded by an unstructured protein layer and a lipid-envelo
https://www.virus-biophysics.lu.se/open-positions-0 - 2025-08-15
Virus Biophysics Virus Biophysics is a rather new field that seeks to define the physical mechanisms controlling virus development. This knowledge can provide information essential to the rational design of new antiviral strategies with less specificity for a limited number of viruses. Furthermore, biological and physical simplicity relative to other biological systems have made viruses an attract
https://www.virus-biophysics.lu.se/research-overview - 2025-08-15
News and Events January 9, 2024 , Physics World "Viruses change structure at the temperature of the human body to better infect us". If you want to know in simple words a possible mechanism of viral genome delivery, read more in this link (it opens a new webpage).November 8, 2023, Lund University press release on our pioneering study published in PNAS showing how temperature triggers release of v
https://www.virus-biophysics.lu.se/node/137 - 2025-08-15
Herpes Simplex 1 pressurized DNA release into a cell nucleus. DNA packaging and capsid reinforcement Illustration and poem inspired by graduate student Krista Freeman's contributions to “The Invisible Jazz Experimental Laboratories”, hosted by The Space Upstairs in Pittsburgh, PA."I've optimized my eyes to fill my brain with dissonance in a balance. The information is a bomb, every fact a potenti
https://www.virus-biophysics.lu.se/movies-artwork - 2025-08-15
Our Biophysical ToolsOur research group investigates mechanics of viral replication, virus-host interactions, virus assembly and disassembly within the host. Specifically, we investigate energetics, structure and mobility of the intra-capsid genome as well as mechanical properties of viral capsids, influenced by changes in physiological environment that are important for viral replication. Main to
https://www.virus-biophysics.lu.se/methods-and-techniques - 2025-08-15
Principal Investigator: Alex Evilevitch, PhDProfessor of Cell Biology Email: Alex [dot] Evilevitch [at] med [dot] lu [dot] se Lab photos PUB night with the group, August 2023 Postdocs José Ramón Villanueva Valencia, PhDEmail: jose_ramon [dot] villanueva-valencia [at] med [dot] lu [dot] se (jose_ramon[dot]villanueva-valencia[at]med[dot]lu[dot]se) Santosh Gawali, PhD Email: santosh [dot]
https://www.virus-biophysics.lu.se/people - 2025-08-15
Alex Evilevitch Research Group We are always interested in reviewing applications from MSc students, prospective PhD students and postdocs.Project description Herpesviruses are a leading cause of human viral disease. Herpesviruses consist of a double-stranded DNA genome contained within a protein shell, termed the capsid, that is surrounded by an unstructured protein layer and a lipid-envelope. H
https://www.virus-biophysics.lu.se/open-positions - 2025-08-15
https://www.virus-biophysics.lu.se/teaching - 2025-08-15
January 9, 2024 , Physics World "Viruses change structure at the temperature of the human body to better infect us". https://physicsworld.com/a/viruses-change-structure-at-the-temperature-of-the-human-body-to-better-infect-us/ November 8, 2023, Lund University press release on our pioneering study published in PNAS showing how temperature triggers release of viral genome by changing the form and
https://www.virus-biophysics.lu.se/news-0 - 2025-08-15
To see Prof. Alex Evilevitch Open Researcher and Contributor ID (ORCID), click the link below (it opens another website):https://orcid.org/0000-0002-0245-9574 Below, there is the full list of publication of Prof. Alex Evilevitch. It links to another webpage related to the publisher.Villanueva Valencia J. R., Li D., Casjens S. R., Evilevitch A., "‘SAXS-osmometer’ method provides measurement of
https://www.virus-biophysics.lu.se/publications - 2025-08-15
We use atomic force microscopy (AFM) nano-indentation method to measure DNA mobility in the capsid. The mobility of DNA packaged inside the HSV-1 capsid is measured by recording the force resisting the capsid indentation when the AFM tip is brought into contact with the DNA-filled capsid in solution. Force resisting the AFM tip indentation of the capsid is recorded as the force-distance curve. Cap
https://www.virus-biophysics.lu.se/methods-and-techniques/atomic-force-microscopy - 2025-08-15
We use cryo electron microscopy (cryo-EM) and image reconstruction to examine the virion structure at subnanometer resolution. We also analyze structure and density of viral DNA packaged in a capsid. Figure: Cutaway views from cryo-EM reconstructions of (A) HSV-1 C-capsid and (B) phage lambda procapsid and mature DNA-filled lambda capsid. HSV-1 and lambda phage capsids are shown to scale. Owing t
https://www.virus-biophysics.lu.se/methods-and-techniques/cryo-electron-microscopy - 2025-08-15
The isothermal titration calorimetry (ITC) provides the most direct method to measure the internal energy of the confined viral genome. In order to experimentally dissect the thermodynamic determinants of viral DNA packaging and ejection energetics, we were first to use ITC to directly measure the heat released by DNA ejection from a virus capsid. This approach allows one to address experimentally
https://www.virus-biophysics.lu.se/methods-and-techniques/microcalorimetry - 2025-08-15
Super-Resolution Structured Illumination Microscopy (SR-SIM) provides resolutions down to 120 nm, allowing visualization of individual herpesvirus capsids (HSV-1) attached to the nucleus (HSV-1 C-capsid diameter is 125 nm). Figure: Imaging of reconstituted capsid-nuclei system confirms specific capsid binding to the NPCs at the nuclear membrane. Representative super-resolution SIM image showing G
