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Background: Complex I (CI or NADH:ubiquinone oxidoreductase) deficiency is the most frequent cause of mitochondrial respiratory chain defect. Successful attempts to rescue CI function by introducing an exogenous NADH dehydrogenase, such as the NDI1 from Saccharomyces cerevisiae (ScNDI1), have been reported although with drawbacks related to competition with CI. In contrast to ScNDI1, which is perm

The development of Pt(IV) anticancer prodrugs to overcome the detrimental side effects of Pt(II)-based anticancer drugs is of current interest. The kinetics and reaction mechanisms of the reductive activation of the carboplatin Pt(IV) prodrug cis,trans-[Pt(cbdca)(NH3)2Cl2] (cbdca = cyclobutane-1,1-dicarboxylate) by the major small-molecule reductants in human plasma were analyzed in this work. The

Patients with colorectal liver metastases (CRLM) increasingly undergo liver resections. The belief is that the resection or ablation of a tumor, when possible, is the only possibility of a cure. The classical strategy is where the primary colorectal tumor is resected as the first intervention, followed by resection of the liver metastasis at a second stage. The liver-first strategy is where preope

The magnetically frustrated spin ice family of materials is host to numerous exotic phenomena such as magnetic monopole excitations and macroscopic residual entropy extending to low temperature. A finite-temperature ordering transition in the absence of applied fields has not been experimentally observed in the classical spin ice materials Dy2Ti2O7 and Ho2Ti2O7. Such a transition could be induced

The Aim of this research is to analyze how the socio-demographic characteristics of users of Complementary and Alternative Medicine (CAM) in Serbia influence and impact their consumption of OTC drugs. Respondents and methods: The study employed the third edition of the National Health Survey of the Republic of Serbia, published in 2013, as a data source covering the Serbian population. The sample

Many state-of-the-art applications for linear accelerators, such as free-electron lasers (FELs) and plasma-wakefield accelerators (PWFAs), require small normalized emittances, and PWFAs in particular are very sensitive to transverse slice offsets along the beam. Dispersive systems, such as bunch compressors, can cause different chromatic aberrations, one of which yields transverse slice offsets. I

Lungwort lichen, Lobaria pulmonaria (L.) Hoffm., was surveyed in the southwesternBaltic Area in 2016–2018. At each of the localities, the habitat ecology and lichen viability were investigated. A substantial decline was noted, particularly in Skåne. The commonest habitats for L. pulmonaria in southernmost Sweden are lime-maple and species-poor, oligotrophic beech forests, and the commonest substra

PurposeThe purpose of this paper is to investigate the association between audit rotation – at the audit partner and audit firm level – and audit quality. As mentioned in the literature, audit rotation has several benefits, and one of them is it can bring a fresh look to audit tasks and subsequently improve audit quality. Moreover, audit itself can help a client to improve its financial reporting.

We address the interplay of electron-electron (e-e) and electron-phonon (e-ph) interactions in the Hubbard- Holstein model, using a two-component density functional theory. Exchange-correlation potentials constructed via dynamical mean field theory for a D = ∞ Bethe lattice and analytically for an isolated site give a new perspective on e-ph screening of the e-e interactions and its effect on the

1,9-Nonanedioic acid is one of the valuable building blocks for producing polyesters and polyamides. Thereby, whole-cell biosynthesis of 1,9-nonanedioic acid from oleic acid has been investigated. A recombinant Corynebacterium glutamicum, expressing the alcohol/aldehyde dehydrogenases (ChnDE) of Acinetobacter sp. NCIMB 9871, was constructed and used for the production of 1,9-nonanedioic acid from

BACKGROUND: Different jump tests such as the Countermovement Jump (CMJ), Abalakov Jump (AJ) and Standing Long Jump (SLJ) are often used in practice to evaluate muscular power and functional performance in football. These tests are also used in different selection processes and talent identification, but the significance of the tests for the selection of youth players to national teams are relative

Partially premixed combustion (PPC) is one of several advanced combustion concepts for the conventional diesel engine. PPC uses a separation between end of fuel injection and start of combustion, also called ignition dwell, to increase the mixing of fuel and oxidizer. This has been shown to be beneficial for simultaneously reducing harmful emissions and fuel consumption. The ignition dwell can be

In the search for low greenhouse gas propulsion, the dual fuel engine provides a solution to use low carbon fuel at diesel-like high efficiency. Also a lower emission of NOx and particles can be achieved by replacing a substantial part of the diesel fuel by for example natural gas. Limitations can be found in excessively high heat release rate (combustion-knock), and high methane emissions. These

In partially premixed combustion engines high octane number fuels are injected into the cylinder during the late part of the compression cycle, giving the fuel and oxidizer enough time to mix into a desirable stratified mixture. If ignited by auto-ignition such a gas composition can react in a combustion mode dominated by ignition wave propagation. 3D-CFD modeling of such a combustion mode is chal

Methanol is a genuine candidate on the alternative fuel market for internal combustion engines, especially within the heavy-duty transportation sector. Partially premixed combustion (PPC) engine concept, known for its high efficiency and low emission rates, can be promoted further with methanol fuel due to its unique thermo-physical properties. The low stoichiometric air to fuel ratio allows to ut

The present work describes the numerical modeling of medium-speed marine engines, operating in a fumigated dual-fuel mode, i.e. with the second fuel injected in the ports. This engine technology allows reducing engine-out emissions while maintaining the engine efficiency and can be fairly easily retrofitted from current diesel engines. The main premixed fuel that is added can be a low-carbon one a

Although references to China were few and fragmentary, the example of a ‘stationary’ East Asian Empire featured importantly in Scottish Enlightenment ideas about religion and political economy. David Hume considered whether the apparently long-flourishing system of Chinese government, grounded in rationally deduced deistic ethics, could provide an example for Western nations. Later in the eighteen

Focusing on artful, embodied listening as a method of analysing the emotional intensities of place, this article calls for academic geographers to listen to practitioners of nonacademic geography. It explores an ethical and methodological agenda for understanding how pop musicians have heard the world, and for taking them seriously as creative geographers who contribute sophisticated interpretatio