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The onset and progression of multiple sclerosis (MS) is accompanied by changes in brain biochemistry. Magnetic resonance spectroscopy (MRS) is a powerful tool for investigating these changes in vivo. Machine learning analysis of MRS-derived biochemical profiles may reveal metabolic patterns inherent in certain MS subtypes to inform their diagnosis. By employing a feature set of only metabolite con
Accurate density matrix simulation of nuclear spin systems is critical for quantifying magnetic resonance spectroscopy (MRS) data, as well as for simulation studies designed to optimize acquisition parameters. Although a variety of packages exist to achieve this result, no currently available software is capable of computing a large number of spatial points in a reasonable time frame. Here we pres
Water is a common internal reference for metabolite quantification by 1H-MRS. We investigate potential influences on water-referenced metabolite quantification by differences in frontal cortex water T2 in individuals with relapsing-remitting, progressive, and no multiple sclerosis. Water T2 differed in monoexponential models, exhibiting highest values in progressive multiple sclerosis only when an
Ross Leadbetter had had a broad and deep influence on the development of proba-bilistic and statistical theory of extreme values and on the application of extreme-value methods. He has been an inspiration and a friend for many of us. This edito-rial collects thirteen personal recollections of Ross and his work. An account of hiscareer and some of his work can be found in the IMS Obituary “Ross Lea
Multiple sclerosis (MS) is an autoimmune disease that damages the central nervous system and affects an estimated 2.3 million people worldwide. One potential key to understanding MS is investigating the metabolic distinctions between its relapsing-remitting (RR-MS) and progressive courses (P-MS). We obtained single-voxel metabolic 1H spectra at 7 Tesla from the frontal cortex of RR-MS and P-MS pat
The tripeptide glutathione (L-γ-glutamyl-L-cysteinyl glycine or GSH) is an endogenous antioxidant implicated in many neurological conditions, including multiple sclerosis. Its precise quantification by proton magnetic resonance spectroscopy is, however, hampered by its uncertain T2. Here, we present a method for the quantification of GSH T2 in the human brain at 7 Tesla using optimized echo time e
Halide perovskites solar cells are now approaching commercialisation. In this transition from academic research towards industrialisation, standardized testing protocols and reliable dissemination of performance metrics are crucial. In this study, we analyze data from over 16,000 publications in the Perovskite Database to investigate the assumed equality between the integrated external quantum eff
En översikt över regleringen av apoteksväsendet i Danmark fram till 1600-talet och i Sverige fram till idag.
There has been a recent proliferation of research and practice on the interior dimensions of sustainability, such as values, beliefs, worldviews and inner capacities. This nascent field of inner transformation is dynamic and emerging, with varied terminology, a breadth of applications, and intense debate about possible contributions as well as limitations and shortcomings. In this article, we aim
Vår forskning visar på att klimatkrisen inte är en kris i det yttre, utan snarare en inre relationskris. Den drivs av växelspelet mellan vårt inre liv och klimat-förändringarna, vilket i nuläget försämrar både det personliga och planetära välbefinnandet. Detta växelspel demonstrerar att våra inre liv inte bara är offer för den ökande klimatpåverkan. Det är också en viktig drivkraft bakom
Solar power and electric vehicles (EV) are set to play a leading role in the achievement of the 2030 EU renewable targets and the commitment to carbon neutrality by 2050. Importantly, solar photovoltaics (PV), in combination with energy storage, also has the potential to significantly enhance European energy security, provide citizens and industry with competitive energy, and lead to the creation
BACKGROUND: Accessibility to surgical services can impact earthquake preparedness and response. We aimed to estimate the population with timely access to surgical care in Guerrero, a Mexican state with high tectonic activity, and identify populations at risk in the event of an earthquake.METHODS: We conducted an ecological study using open government data. We extracted data from Guerrero municipal
The purpose of this booklet is to offer easy-to-use guidelines for businesses to design and implement circularity strategies into their business model. Specifically, the booklet will provide step-by-step guidance on how to ideate, design, test, and scale novel circular business models. For each stage of this circular business model innovation (CBMI) process a selection of tools and methods will be
The rapid expansion of the global solar photovoltaic (PV) market as part of the transition to a low-carbon energy future will increase both demand for raw materials used in PV product manufacturing as well as future PV panel waste volumes. There is an urgent need for solar industry businesses to adopt circular business models, and to support this process through targeted tools and methods that can
This report compiles the findings of two business experiment surveys, conducted under CIRCUSOL Task 2.4. The experiments investigated customer preferences for two relatively novel market segments for circular photovoltaics, specifically (1) solar-powered charging stations for shared micro-mobility services, and (2) PV-systems for home-charging of electric vehicles. The experiments used the method
This report compiles the findings concerning the “Initial version of CBMD framework and co-creation process approach”, hereafter be referred to as “circular product-service system innovation support method” (cPSS method). The report has been compiled from an extensive review of the literature from a variety of inter-related academic research fields, including business model theory, product service
Hard-to-reach (HTR) energy users encompass individuals who are physically difficult to reach, underserved, or challenging to engage and motivate in demand-side energy programmes. Given a mix of societal challenges (e.g. inequity, energy poverty, decarbonisation, the COVID-19 pandemic), HTR energy users are receiving increasing attention. However, there is a lack of knowledge on the performance of
