Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.

In this study, the integral pulse frequency modulation model is extended to account for the presence of ectopic beats and heart rate turbulence (HRT). Based on this model, a new statistical approach to the detection and characterization of HRT is presented. The detector structure involves a set of Karhunen-LoEve basis functions and a generalized likelihood ratio test statistic T(x) . The three mos

In this work we perform a high-resolution spectroscopic investigation of Eu3+-Ce3+ and Pr3+-Ce3+ codoped Y2SiO5 crystals. Satellite line spectra were recorded at low temperatures around the Eu3+:F-7(0) -> D-5(0) and the Pr3+:H-3(4) -> D-1(2) transitions. It is observed that the incorporation of Ce3+ as a codopant notably changes the Eu3+ and Pr3+ satellite line patterns. Satellite lines measured i

In most species, males do not abandon offspring or reduce paternal care when they are cuckolded by other males. This apparent lack of adjustment of paternal investment with the likelihood of paternity presents a potential challenge to our understanding of what drives selection for paternal care. In a comparative analysis across birds, fish, mammals, and insects we identify key factors that explain

Fires can be an important hazard for the overall safe operation of nuclear power plants. Prevention of fire, fast detection and efficient extinguishment of a fire are some parameters, which are important to consider when designing the fire safety in a nuclear power plant. As an alternative to extinguishment system the use of hypoxic air or hypoxic air venting has been introduced e.g. in storage ro

For small deformations a crack/interface model that considers general 3D normal and shear loading is proposed. It involves elasticity, plasticity and damage and it is thermodynamically based. An essential feature of the model is its consistency with the concepts behind the fictitious crack model. In particular, no crack deformation occurs before the crack is initiated and when a crack has just bee

Motion estimation in a series of consecutive images is used in a variety of areas, e.g. video compression and investigation of tissue characteristics and organ function in medical images. Several methods exist both for estimating motions on a pixel level, e.g. block-matching in which two blocks in consecutive images are compared by an evaluation metric, and on a sub-pixel level. In this paper, we

Deep sternal wound infection (DSWI) following cardiothoracic surgery is a rare but potentially life-threatening complication with high morbidity and mortality. DSWI is associated with a significant increase in the length of hospital stay and the cost of hospitalization. The socioeconomic impact of DSWI is considerable. Conventional treatment includes reexploration, surgical debridement, mediastin

Socio-technical methods advocate a human-focus analysis that reflects on social and technical factors in the design of organizational systems. The aim of this paper is to report on the experiences of a ST toolbox use in practice by 36 companies. Our findings show that the use of ST toolbox improves companies’ understanding of their job practices and enhance their learning about their business sust

Methane (CH4) emission from boreal, arctic and subarctic wetlands constitutes a potentially positive feedback to global climate warming. Many process-based models have been developed, but high uncertainties remain in estimating the amount of CH4 released from wetlands at the global scale. This study tries to improve estimates of CH4 emissions by up-scaling a wetland CH4 emission model, PEATLAND-VU

This article is devoted to introduce a new class of nonassociative algebras with involution including the class of structurable algebras.

Popular Abstract in Swedish Diabetes mellitus är en samling sjukdomar som karaktäriseras av förhöjt blodsocker. Traditionellt har man delat upp sjukdomen i två former; typ 1 och typ 2 diabetes. Vid typ 1 diabetes förstörs de insulinproducerande β-cellerna i bukspottskörteln av kroppens immunförsvar och sjukdomen debuterar ofta tidigt i livet. Typ 2 diabetes, tidigare ofta benämnd ”åldersdiabetes” Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. However, the role of 5-HT in control of insulin rel

Serine/arginine (SR) protein-specific kinase (SRPK), a family of cell cycle-regulated protein kinases, phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing. However, the physiologic roles of this event in cell cycle are incompletely understood. Here, we show that SRPK2 binds and phosphorylates acinus, an SR protein essential for RNA splicing, and redist

Background: Transanal endorectal one-stage pull-through (TERPT) procedure in children with Hirschsprung’s disease (HD) is frequently used worldwide. In order to give the families realistic expectations and to plan the medical care for the years after TERPT, the long term outcome is of great importance. Aim: To collect information on the long term outcome reported after one stage TERPT procedure fo

We propose a sender-specific blockmodel for network data which utilizes both the group membership and the identities of the vertices. This is accomplished by introducing the edge probabilities $(\theta_{i, v})$ for $1\le i\le c, 1\le v\le n$, where $i$ specifies the group membership of a sending vertex and $v$ specifies the identity of the receiving vertex. In addition, group membership is conside