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OBJECTIVE: This study aimed to evaluate patients with bipolar I disorder (BD-I) who have mania with depressive symptoms and who meet the new "with mixed features" specifier of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5).METHOD: This prospective, multinational, naturalistic study surveyed psychiatrists and their patients with BD-I from October 2013 to March 2014
BACKGROUND: In recent years the association between sexual dysfunction (SD) and obesity in the general population has drawn major attention. Although sexual dysfunction is common in psychosis, its relationship with weight gain and obesity remains unclear.AIMS: To investigate the association between sexual dysfunction and obesity in a cohort of patients with first episode psychosis.METHOD: Sexual f
During the last decade, a vast amount of research has been produced concerning the efficacy of different pharmacological and psychological treatments in psychiatry for various diagnoses. This movement towards evidence-based practices has aimed at grounding clinical practice in evidence derived from research, to optimize outcomes. Such developments should translate into the successful management of
Background: Manic episodes with depressive symptoms represent a severe presentation of bipolar disorder. The effi-cacy of drugs shown useful for pure mania is largely unproven in the subset of patients with depressive symptoms. We reviewed different post-hoc analyses evaluating asenapine's effects in patients experiencing depressive symptoms during manic episodes. Methods: Different post-hoc analy
IMPaCT is a five-year project funded by the Department of Health, UK. Running in the UK and now Sweden, the IMPACT Project aims to target the poor physical health and excessive substance use seen in people with SMI. There is evidence that behavioural interventions may be associated with an improvement in physical health and substance use in this population. IMPaCT is a randomised controlled trial
Attention Deficit Hyperactivity Disorder (ADHD) is a widely spread diagnosis.The dominant paradigm of ADHD is biomedical where ADHD isdefined as a brain disorder. At the same time, the legitimacy of thediagnosis is being questioned since it is unclear whether or not ADHDcan be deemed a medical disorder in itself. The aim of this article is tocritically assess the merits of understanding the diagnoAttention Deficit Hyperactivity Disorder (ADHD) is a widely spread diagnosis.The dominant paradigm of ADHD is biomedical where ADHD isdefined as a brain disorder. At the same time, the legitimacy of thediagnosis is being questioned since it is unclear whether or not ADHDcan be deemed a medical disorder in itself. The aim of this article is tocritically assess the merits of understanding the diagno
We tested domestic cats in the cylinder task, and found that they perform better ifthe cylinder is larger. We also found that their highest performance parallels that ofgreat apes and corvids, which are known as the best performing animals on this task.The cylinder task is used to test animals’ motor self-regulation. Recently a large-scalestudy tested 36 species on the task and found that absolute
We tested domestic cats in the so-called cylinder task, and found that they perform better if the cylinder is larger. We also found that their highest performance parallels that of great apes and corvids, which are known as the best performing animals on this task. The cylinder task is used to test animals’ motor self-regulation: the inhibition of unproductive, but prepotent, movements in favour o
The process of biogas upgrading with ionic liquids, i.e. pure 1-butyl-3-methylimidazolium bis(trifluoro-methylsulfonyl)imide ([bmim][Tf2N]), aqueous choline chloride/urea (ChCl/Urea), and aqueous 1-allyl-3-methyl imidazole formate ([Amim][HCOO]), was simulated in Aspen Plus and compared with the conventional water scrubbing upgrading technique. The comparisons of the performances on the amount of
There is an assumption in current landscape preference theory of universal consensus in human preferences for moderate to high openness in a natural landscape. This premise is largely based on empirical studies of urban Western populations. Here we examine for the first time landscape preference across a number of geographically, ecologically and culturally diverse indigenous populations. Included
Affinal avoidance registers are strategies of restrained linguistic conduct in relation to one’s in-laws. Current theories are primarily concerned with two types of strategies: (1) taboos on uttering the proper names of affines, and (2) substitution of everyday words with dedicated parallel lexicon in the presence of affines (so-called “mother-in-law languages”). However, the role of pronouns has
Objectives: This study illuminated the meanings of existential loneliness (EL) as narrated by frail older people. Method: Data were collected through individual narrative interviews with 23 people 76–101 years old receiving long-term care and services. A phenomenological hermeneutical analysis was performed, including a naïve reading and two structural analyses as a basis for a comprehensive under
Botulinum neurotoxins (BoNTs) are the most potent toxins known. So far, eight serotypes have been identified that all act as zinc-dependent endopeptidases targeting SNARE proteins and inhibiting the release of neurotransmitters. Recently, the first botulinum toxin-like protein was identified outside the Clostridial genus, designated BoNT/Wo in the genome of Weissella oryzae. Here, we report the 1.
The effect of barrier properties on in vitro intestinal lipolysis of three different types of emulsions based on oil-in-water starch granule Pickering stabilization has been investigated including non-heat treated, heat treated (gelatinized) and heat treated and stored (retrograded) emulsions. The stability of starch covered oil-water interfaces towards in vitro intestinal lipolysis was correlated
This work illustrates the impact of atmospheric gases on the surface of epitaxial graphene. The different rate of adsorption on different parts of graphene samples provides a concrete evidence that the surface morphology of graphene plays a significant role in this process. The uneven adsorption occurs only on the surface of the monolayer graphene and not on bilayer graphene. The second monolayer
