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Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

Erythroid cell commitment and differentiation proceed through activation of a lineage-restricted transcriptional network orchestrated by a group of cell fate determining and maturing factors. We previously set out to define the minimal set of factors necessary for instructing red blood cell development using direct lineage reprogramming of fibroblasts into induced erythroid progenitors/precursors

Evidence for a southward autumn migration of nocturnal noctuid moths in central Europe

Insect migrations are spectacular natural events and resemble a remarkable relocation of biomass between two locations in space. Unlike the well-known migrations of daytime flying butterflies, such as the painted lady (Vanessa cardui) or the monarch butterfly (Danaus plexippus), much less widely known are the migrations of nocturnal moths. These migrations - typically involving billions of moths f

Treaty-specific conferences, including review conferences

Bidraget sammanställer de konferensformat som etablerats inom ramen för internationella nedrustnings- och rustningskontrollfördrag, förklarar dessas specifika procedurbestämmelser och analyserar dessas ändamålsenlighet och effektivitet i ljuset av respektive traktats syfte och mot bakgrund av de erfarenheter som samlats vid konferensernas genomförande.

Analysis of Animal Bedding Heterogeneity for Potential Use in Biorefineries Based on Farmyard Manure

Animal bedding, a mixture of straw and manure, could be used as a feedstock for bioenergy production, but its heterogeneity poses new challenges in its use in biorefineries. We have investigated the origin of this heterogeneity and quantified it, and discuss its impact on bioenergy production. Samples were collected from the bedding at different points and depths and analysed by first separating t

Arterial Input Functions and Tissue Response Curves in Dynamic Glucose-Enhanced (DGE) Imaging: Comparison Between glucoCEST and Blood Glucose Sampling in Humans

Dynamic glucose-enhanced (DGE) imaging uses chemical exchange saturation transfer magnetic resonance imaging to retrieve information about the microcirculation using infusion of a natural sugar (D-glucose). However, this new approach is not yet well understood with respect to the dynamic tissue response. DGE time curves for arteries, normal brain tissue, and cerebrospinal fluid (CSF) were analyzed

Development of specific monoclonal antibodies against different forms of alpha-synuclein as diagnostic tools for synucleinopathies

Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies(DLB) and multiple system atrophy (MSA), are a group of neurodegenerative disorders characterized by the abnormal accumulation of insoluble alpha-synuclein (α-syn) aggregates in the brain. The detection of α syn pathology has relied vastly on the use of several antibodies, which were mostly generated against different

Are Model Cities an Effective Instrument for Urban Environmental Governance?

Since the 1980s, China’s central government has created various model and incentive schemes aimed at systematically and concurrently promoting innovative approaches for protecting the urban ecological environment. In this context, programmes such as the ‘model city for protecting the environment’, ‘garden city’, ‘eco-city’, or ‘low-carbon city’ have become an integral part of China’s system for ur

Så har kartorna format världshistorien

Recension av Tim Marshall, Geografins makt: Tio kartor som förklarar världen, övers. Pär Svensson, Volante, Stockholm 2018 (343 s.) och Thomas Reinertsen Berg, Kartornas historia, övers. Jan Wibom, Lind & Co, Stockholm 2018 (351 s.).