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α1-Adrenergic receptors from the cultured smooth muscle cell line (DDT1 MF-2) have been solubilized with digitonin and purified to apparent homogeneity by sequential chromatography on a biospecific affinity support (Sepharose-A55453 (4-amino-6,7-dimethoxy-2-[4-[5-(4-amino-3-phenyl)pentanoyl]- 1-piperazinyl]-quinazoline), an α1 receptor-selective antagonist), a wheat germ agglutinin-agarose gel, an

Abstract: The adrenergic receptors of rat pineal gland were investigated using radiolabeled ligand binding and photoaffinity labeling techniques. 125I‐2‐[β‐(4‐hydroxyphenyl)ethylaminomethyl]tetralone (125I‐HEAT) and 125I‐cyanopindolol (125I‐CYP) labeled specific sites on rat pineal gland membranes with equilibrium dissociation constants (KD) of 48 (±5) pM and 30 (±5) pM, respectively. Binding site

Follicular lymphoma (FL) is a heterogeneous disease with varying prognosis owing to differences in clinical, laboratory, and disease parameters. Although generally considered incurable, prognosis for early- and advanced-stage disease has improved because of therapeutic advances, several of which have resulted from elucidation of the biologic and molecular basis of the disease. The choice of treatm

The emotions of defence lawyers have garnered little sociological attention. This is surprising as their role requires them to show loyalty to clients, representing them in court, irrespective of the client or the crime. Theirs is thus an emotionally demanding role, requiring the management of inappropriate emotions. This article explores this by showing that justice systems have structurally embe

Research Question/Issue: This paper examines the impact of changes in board independence on the market valuation of Swedish firms. I exploit an exogenous change to the rules of corporate governance in 2005, which requires large firms to have majority independent boards, as a quasi‐experimental setting.Research Findings/Insights: I use a regression discontinuity design and a difference‐in‐differenc

Novel therapies such as type 2 targeting biologics are emerging treatment options for patients with chronic inflammatory respiratory diseases, fulfilling the needs of severely uncontrolled patients. The majority of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and over half of patients with asthma show a type 2 inflammatory signature in sinonasal mucosa and/or lungs. Importantly,

This article reports the result of a survey designed to investigate the degree of uncertainty by which a representative sample of Swedish households hold their perceptions and expectations of inflation. The public displays hardly any uncertainty concerning the direction of change of the price level as measured by the ratio of ‘don’t know’ answers. However, when asked for numerical estimates of theThis article reports the result of a survey designed to investigate the degree of uncertainty by which a representative sample of Swedish households hold their perceptions and expectations of inflation. The public displays hardly any uncertainty concerning the direction of change of the price level as measured by the ratio of ‘don’t know’ answers. However, when asked for numerical estimates of the

The use of ultra-low power wake-up receivers (WuRx) can significantly reduce idle listening energy cost. To tailor a WuRx scheme to orthogonal frequency division multiplexing (OFDM) based systems, such as LTE-MTC or IEEE 802.11, the wake-up signal (WUS) also needs to follow OFDM principles to avoid interfering with other transmissions in the same shared bandwidth. Here, we address this particular

The pollen extract Cernitin® is widely used for treatment of benign prostatic hyperplasia (BPH) and non-bacterial chronin prostatitis. However, little is known about the underlying molecular mechanisms to explain the clinical effects of Cernitin®. In this study, we sought to investigate the cellular mechanisms by which Cernitin® induces its effects on human prostatic cell lines BPH-1 and WPMY-1 an

Inspired by the recently-reported strong electric-dipole (E1) transition between the weakly-bound first and second excited states, 3/2- at 765 keV and 1/2+ at 885 keV, in the nucleus Ne171027, the E1 transition is estimated in a model by properly taking into account the effect of both deformation and weakly-bound neutrons. In addition to both the spin-parities, 1/2+ and 3/2-, and observed nearly d

Background: Despite its well-established positive effects, exercise-based cardiac rehabilitation (exCR) is underused in patients following an acute myocardial infarction (AMI). The aim of the study was to identify factors associated with non-Attendance at exCR in patients post-AMI in a large Swedish cohort. Methods: A total of 31,297 patients who have suffered an AMI, mean age 62.4 ± 4 years, were

Background: Vitamin D has been suggested to prevent and improve the prognosis of several cancers, including breast cancer. We have previously shown a U-shaped association between pre-diagnostic serum levels of vitamin D and risk of breast cancer-related death, with poor survival in patients with the lowest and the highest levels respectively, as compared to the intermediate group. Vitamin D exerts

Solid polymer electrolytes (SPEs) are promising alternatives to the flammable liquid electrolytes that are currently used in most commercial lithium-ion batteries. Because the transport of ions occurs through segmental motions of the polymer, ionic conductivity typically decreases as the mechanical strength of the SPE increases [1]. Much research has been devoted to the use of microphase separatio