OBJECTIVE-Human blood glucose levels have likely evolved toward their current point of stability over hundreds of thousands of years. The robust population stability of this trait is called canalization. It has been represented by a hyperbolic function of two variables: insulin sensitivity and insulin response. Environmental changes due to global migration may have pushed some human subpopulations

An atmospheric, variable-swirl combustor was used to study the influence of syngas composition on the lean blowout (LBO) limit under various flow conditions created at different swirl numbers. The fuels used in the experiments consisted of generic mixtures of CO, H-2, and CH4. The results were compared to those for CH4 at the same swirl numbers. The effect of dilution on the LBO limit was studied

Epigenetic code modifications by histone deacetylase inhibitors (HDACis) have recently been proposed as potential new therapies for hematological malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common form of aggressive lymphoma. At present, standard first line treatment for DLBCL patients is the antracycline-based chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristi

Nanocrystalline Cr2O3 thin films were deposited on silicon wafers with (100) orientation by arc ion plating (AIP) technique at various negative bias voltages. By virtue of X-ray diffraction analysis, scanning electron microscope, and high-resolution transmission electron microscope, the influence of substrate bias voltage on the film growth process, microstructure, and characteristics was investig

The performance of continuous time deltasigma modulators is limited by their large sensitivity to feedback pulse-width variations caused by clock jitter in their feedback DACs. To mitigate that effect, a dual switched- capacitor-resistor feedback DAC technique is proposed. The architecture has the additional benefit of reducing the typically high switched-capacitor-resistor DAC output peak current

Objective: To determine the interobserver agreement (IOA) of neonatal seizure detection using the gold standard of conventional, multichannel EEG. Methods: A cohort of full-term neonates at risk of acute encephalopathy was included in this prospective study. The EEG recordings of these neonates were independently reviewed for seizures by three international experts. The IOA was estimated using sta

This study analyses the effects of thinning on stand transpiration in a typical mixed spruce and pine forest in the southern boreal zone. Studies of transpiration are important for models of water, energy and carbon exchange, and forest management, like thinning, would change those processes. Tree transpiration was measured by the tissue heat-balance sapflow technique, on a reference plot and a th

Aims. A transient astrophysical event observed in both gravitational wave (GW) and electromagnetic (EM) channels would yield rich scientific rewards. A first program initiating EM follow-ups to possible transient GW events has been developed and exercised by the LIGO and Virgo community in association with several partners. In this paper, we describe and evaluate the methods used to promptly ident

Recent work in multiple view geometry has focused on obtaining globally optimal solutions at the price of computational time efficiency. On the other hand, traditional bundle adjustment algorithms have been found to provide good solutions even though there may be multiple local minima. In this paper we justify this observation by giving a simple sufficient condition for global optimality that can

Objective: To evaluate gender differences in score on 28-joint Disease Activity Score (DAS28), Health Assessment Questionnaire (HAQ) and Signals Of Functional Impairment (SOFI) and to relate these scores to radiographic joint destruction. Methods: In all, 549 patients with early RA (62% women) from the BARFOT (for "Better Anti-Rheumatic FarmacOTherapy'') study were included. At baseline, 1, 2 and

Lifetime experience of selling sex among adolescents was investigated together with sociodemographic correlates, parentchild relationship, and the existence of people to confide in. Changes over time regarding the selling of sex were investigated through a comparison of data from 2004 and 2009. This study was carried out using 3,498 adolescents from a representative sample of Swedish high school s

Migration is a commonly described phenomenon in nature that is often caused by spatial and temporal differences in habitat quality. However, as migration requires energy, the timing of migration may depend not only on differences in habitat quality, but also on temporal variation in migration costs. Such variation can, for instance, arise from changes in wind or current velocity for migrating bird

TASISpec (TASCA in Small Image mode Spectroscopy) combines composite Ge- and Si-detectors for a new detector setup aimed towards multi-coincidence gamma -ray, X-ray, conversion electron, fission fragment, and a-particle spectroscopy of the heaviest nuclei. It exploits the TASCA separator's unique small image focal mode, i.e. the fact that evaporation residues produced in fusion-evaporation reactio