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Neuroscience and clinical researchers are increasingly interested in quantitative magnetic resonance imaging (qMRI) due to its sensitivity to micro-structural properties of brain tissue such as axon, myelin, iron and water concentration. We introduce the hMRI-toolbox, an open-source, easy-to-use tool available on GitHub, for qMRI data handling and processing, presented together with a tutorial and
A third of dementia cases could be attributable to modifiable risk-factors. Midlife high-density lipoprotein cholesterol (HDL-C) is a measure which could help identify individuals at reduced risk of developing age-related cognitive decline. The Japan Public Health Centre-based prospective (JPHC) Study is a large population-based cohort which started in 1990. This study included 1299 participants f
Region Skåne gjorde under perioden 2005-2012 hela resan från fastanslagsfinansiering av sjukhusen till en rörlig ersättningsmodell och tillbaka till anslagsfinansiering igen. Den här rapporten syftar till att undersöka konsekvenser av återgången till anslagsmodellen inom sjukhusvården i Skåne, närmare bestämt hur och varför återgången påverkat den dagliga verksamheten och synen på styrning mellan
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible du
Purpose: To report the findings in 3 cases of bilateral negative electroretinograms (ERGs) with acute onset of photophobia. Study design: Retrospective case series. Methods: The medical charts of the 3 patients were reviewed. Results: A 43-year-old woman, a 68-year-old woman, and a 41-year-old woman were referred to Nagoya University Hospital. Their main symptom was bilateral acute photophobia. No
BACKGROUND: Pressure-volume (PV) loops provide a wealth of information on cardiac function but are not readily available in clinical routine or in clinical trials. This study aimed to develop and validate a noninvasive method to compute individualized left ventricular PV loops. METHODS: The proposed method is based on time-varying elastance, with experimentally optimized model parameters from a tr
The oxidation of soot is a complex process due to the heterogeneous structure of the material. Several mechanisms have been hypothesized based on ex situ studies, but need confirmation from in situ observation; furthermore, deeper insight is needed to develop and validate structure-dependent reaction mechanisms. In this work, soot oxidation was for the first time observed at atomic scale in situ,
A search for decays of the Higgs boson into a pair of new spin-zero particles, H→aa, where the a-bosons decay into a b-quark pair and a muon pair, is presented. The search uses 36.1 fb−1 of proton–proton collision data at s=13 TeV recorded by the ATLAS experiment at the LHC in 2015 and 2016. No significant deviation from the Standard Model prediction is observed. Upper limits at 95% confidence lev
In this Letter, the ALICE Collaboration presents the first measurements of the charged-particle multiplicity density, dNch/dη and total charged-particle multiplicity, Nch tot, in Xe–Xe collisions at a centre-of-mass energy per nucleon–nucleon pair of sNN=5.44TeV. The measurements are performed as a function of collision centrality over a wide pseudorapidity range of −3.5<η<5. The values of dNch/dη
There is a general belief that a full-thickness eyelid defect is best repaired using a vascularized flap in combination with a free graft, and that a free full-thickness eyelid graft would not survive due to poor blood perfusion. However, we describe a case in which an upper eyelid was traumatically amputated. The eyelid was sutured in place and healed well in situ. The long-term outcome was good
III-V semiconductor nanowires made of materials which have the zinc blende crystal structure in bulk are well known to exhibit either the zinc blende or the wurtzite crystal structure. Understanding and controlling which crystal structure that forms is of highest importance for nanowire applications in a variety of areas. In addition to this, composition control in ternary nanowires is another key
Ten years after its introduction, equity in human papillomavirus (HPV) vaccine uptake remains unattained, not least for the groups at highest risk of cervical cancer. In Sweden, three different delivery modes of the vaccine have been in effect since May 2007. We used this as a natural experiment to investigate girls’ HPV vaccine uptake in relation to parental country of birth and socioeconomic cha
Mötet mellan Trump och Kim innebär en sällsynt chans till fred. Därför borde vi i Europa vara positiva och stöttande istället för cyniska, skriver Paul O'Shea.
Several traffic modeling tools are currently available for evacuation planning and real-time decision support during emergencies. This paper reviews potential traffic-modeling approaches in the context of wildland-urban interface (WUI) fire-evacuation applications. Existing modeling approaches and features are evaluated pertaining to fire-related, spatial, and demographic factors; intended applica
The “neurotrophic hypothesis of depression” posits that low levels of brain-derived neurotrophic factor (BDNF) are associated with Major Depressive Disorder (MDD). Low levels of BDNF have also been found in individuals with suicide attempts, in MDD or other disorders, suggesting that low BDNF may also be associated with suicidality. We assessed serum BDNF in 68 physically healthy and unmedicated (
The notion of creative city has been extensively discussed both in academic debate as well as public discourse, including on Asian context. However, a tendency to study only on strategic government policies in relation to this matter has led many multidimensional aspects being left behind. One of these important aspects is the creativity-based activities initiated and conducted by local groups, co
Iron’s abundance and rich coordination chemistry are potentially appealing features for photochemical applications. However, the photoexcitable charge-transfer (CT) states of most Fe complexes are limited by picosecond or sub-picosecond deactivation through low-lying metal centered (MC) states, resulting in inefficient electron transfer reactivity and complete lack of photoluminescence. Here we sh
