The exceptional polymorphism observed within genes of the major histocompatibility complex (MHC), a core component of the vertebrate immune system, has long fascinated biologists. The highly polymorphic classical MHC class-I (MHC-I) genes are maintained by pathogen-mediated balancing selection (PMBS), as shown by many sites subject to positive selection, while the more monomorphic non-classical MH

As tech giants such as Apple and Meta invest heavily in Virtual and Augmented Reality (VR/AR) technologies, often collectively termed Extended Reality (XR) devices, a significant societal concern emerges: The use of eye-tracking technology within these devices. Gaze data holds immense value, revealing insights into user attention, health, and cognitive states. This raises substantial concerns over

In atopic dermatitis (AD), Staphylococcus aureus fre-quently colonizes lesions, leading to superinfections that can then lead to exacerbations. The presence of biofilm-producing isolates has been associated with worsening of the disease. Potassium permanganate is used as a topical treatment of infected eczema, bliste-ring conditions, and wounds. Little is known of its effects against microbes in A

We study quantum steering experiments without assuming that the trusted party can perfectly control their measurement device. Instead, we introduce a scenario in which these measurements are subject to small imprecision. We show that small measurement imprecision can have a large detrimental influence in terms of false positives for steering inequalities, and that this effect can become even more

Haemoproteus blood parasites of birds are thought to be relatively benign. Recent findings show that infections may develop in the brain of birds, possibly distorting their orientation sense. Misdirected migration may lead migrants outside their range where they are recognized as vagrants and can transmit parasites to novel hosts.

Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available to organisms. The detailed mechanism of this enzyme is currently not known, and computational studies are complicated by the fact that different density functional theory (DFT) methods give very different energetic results for calculations involving nitrogenase models. Recently, we designed a [Fe(SH)4H]

Four-wave mixing techniques, such as coherent anti-Stokes Raman spectroscopy (CARS), laser-induced grating spectroscopy (LIGS), and degenerate four-wave mixing (DFWM), have been widely used in combustion diagnostics due to their advantages of high signal-to-noise ratio (S/N), coherent signal, and spatial resolution. In this work, a nano-second pulsed laser is utilized to generate mid-infrared (nea

Boken innehåller aktuella lagändringar och domstolsbeslut för att enkelt se att medborgaren får rätt stöd. Den klara och begripliga framställningen rätar snabbt ut de flesta frågetecknen kring lagens innehåll och tillämpning.

Particle sintering and reshaping constitute the main cause for catalyst deactivation. An atomic-scale understanding of the correlation among the catalyst structure, its support, and the gas phase under realistic reaction conditions is required for its suppression. In this study, we combined high-energy grazing incidence X-ray diffraction, in situ mass spectrometry, ex situ scanning electron micros

Objectives To investigate the relation between patient characteristics at rheumatoid arthritis (RA) diagnosis and subsequent initiation of treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) or targeted synthetic DMARDs (tsDMARDs). Design A retrospective cohort study. Setting and participants Consecutive patients (N=330) with early RA (symptom duration

The interplay of electronic and nuclear degrees of freedom presents an outstanding problem in condensed matter physics and chemistry. Computational challenges arise especially for large systems, long time scales, in nonequilibrium, or in systems with strong correlations. In this work, we show how downfolding approaches facilitate complexity reduction on the electronic side and thereby boost the si

Background. The concept of schizotypal personality disorder (SPD) emerged from observations of personality characteristics common in relatives of schizophrenic patients. While often studied in family designs, few studies and none with genetic measures, have examined SPD in epidemiological samples. Methods. We studied individuals born in Sweden 1940–2000 with an ICD-10 diagnosis of SPD with no prio

There is increased interest in developing markers reflecting microstructural changes that could serve as outcome measures in clinical trials. This is especially important after unexpected results in trials evaluating disease-modifying therapies targeting amyloid-β (Aβ), where morphological metrics from MRI showed increased volume loss despite promising clinical treatment effects. In this study, ch

Context. In the last 15 years different ground-based spectroscopic surveys have been started (and completed) with the general aim of delivering stellar parameters and elemental abundances for large samples of Galactic stars, complementing Gaia astrometry. Among those surveys, the Gaia-ESO Public Spectroscopic Survey, the only one performed on a 8m class telescope, was designed to target 100 000 st

Background: Quantitative risk assessment (QRA) for skin sensitization is used to derive safe use levels of sensitising fragrance ingredients in products. Post-marketing surveillance of the prevalence of contact allergy to these ingredients provides relevant data to help evaluate the performance of these measures. Objectives: To determine a suitable patch test concentration for five fragrance mater

ObjectiveTo investigate associations between postural orientation errors (POEs) in patients undergoing rehabilitation for anterior cruciate ligament reconstruction (ACLR) and patient-reported outcomes (PROMs) at 2-year follow-up.DesignProspective cohort study.MethodsFifty-three participants (mean (SD) 27 (6.5) years, 24 women), (mean (range) 7 (4–10) months post ACLR) were included. At baseline, a