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Synthesis of 14-oxa-1,4,8,11-tetraazabicyclo[9,5,3]nonadecane (L1) and a Spectroscopic and Structural Study of [Ni(L1)(ClO4)](ClO4) and of the Macrobicyclic Precursor Diamide Complex, [Ni(HL2)](ClO4); Chloride Substitution Kinetics of the Corresponding [Ni(III)(L1)]3+ Species

The pentadentate ligand 14-oxa-1,4,8,11-tetraazabicyclo[9.5.3]nonadecane (L1) has been synthesized by the high dilution cyclization of 1-oxa-4,8-diazacyclododecane ([10]aneN2O) (1) with 1,3-bis(α-chloroacetamido)propane (2) and subsequent reduction of the diamide intermediate. The structure [Ni(L1)(ClO4)](ClO4) (P21/c (no. 14), a = 8.608(3), b = 16.618(3), c = 14.924(4) Å, β = 91.53(3)° converged

Compliance with guidelines for postoperative pain management in infants and children

Background: Postoperative pain is still often being inadequately assessed and/or recorded in infants and young children despite evidence-based guidelines. Objectives: This prospective, observational study in a paediatric postoperative ward at a Swedish university hospital was designed to evaluate interventional effects on pain management by briefly reminding nursing staff of corresponding local gu

High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1

OBJECTIVE—: Plasma high-density lipoproteins (HDL) are potent antiatherogenic and anti-inflammatory particles. However, HDL particles are highly heterogenic in composition, and different HDL-mediated functions can be ascribed to different subclasses of HDL. Only a small HDL population contains apolipoprotein M (ApoM), which is the main plasma carrier of the bioactive lipid mediator sphingosine-1-p

A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing

Detailed characterization and mapping of oligonucleotide function in vivo is generally a very time consuming effort that only allows for hypothesis driven subsampling of the full sequence to be analysed. Recent advances in deep sequencing together with highly efficient parallel oligonucleotide synthesis and cloning techniques have, however, opened up for entirely new ways to map genetic function i

Laparoscopic distal pancreatectomy in elderly patients : is it safe?

Background: Laparoscopic distal pancreatectomy (LDP) appears to be safe and effective as open distal pancreatectomy (ODP) for benign or borderline malignant lesion. However, studies comparing LDP with ODP in elderly patients are limited. The purpose of this study is to compare the clinical outcomes of these two several approaches in elderly patients. Methods: A retrospective analysis was carried o

Mineral Type Structures Soil Microbial Communities

Soil microorganisms living in close contact with minerals play key roles in the biogeochemical cycling of elements, soil formation, and plant nutrition. Yet, the composition of microbial communities inhabiting the mineralosphere (i.e., the soil surrounding minerals) is poorly understood. Here, we explored the composition of soil microbial communities associated with different types of minerals in

Impact of Evapotranspiration Formulations at Various Elevations on the Reconnaissance Drought Index

Numerous drought indices with various intricacy have been utilised in several climatic regions. Presently, the reconnaissance drought index (RDI), which is considered as a powerful index of meteorological drought, is acquisitioning approval primarily in semi-arid and arid climatologic areas. Because RDI is based on precipitation (P) and evapotranspiration (ET), it assesses the ET estimation effect

Super-Resolution Genome Mapping in Silicon Nanochannels

Optical genome mapping in nanochannels is a powerful genetic analysis method, complementary to deoxyribonucleic acid (DNA) sequencing. The method is based on detecting a pattern of fluorescent labels attached along individual DNA molecules. When such molecules are extended in nanochannels, the labels create a fluorescent genetic barcode that is used for mapping the DNA molecule to its genomic locu

Electronic ground state of Ni 2 +

The Φ9/24 ground state of the Ni2+ diatomic molecular cation is determined experimentally from temperature and magnetic-field-dependent x-ray magnetic circular dichroism spectroscopy in a cryogenic ion trap, where an electronic and rotational temperature of 7.4±0.2 K was reached by buffer gas cooling of the molecular ion. The contribution of the spin dipole operator to the x-ray magnetic circular

Annual 10-Month Aerial Life Phase in the Common Swift Apus apus

The common swift (Apus apus) is adapted to an aerial lifestyle, where food and nest material are captured in the air. Observations have prompted scientists to hypothesize that swifts stay airborne for their entire non-breeding period [1, 2], including migration into sub-Saharan Africa [3–5]. It is mainly juvenile common swifts that occasionally roost in trees or buildings before autumn migration w

Evaluating the Psychometric Properties of the Eating Assessment Tool (EAT-10) Using Rasch Analysis

Early and reliable screening for oropharyngeal dysphagia (OD) symptoms in at-risk populations is important and a crucial first stage in effective OD management. The Eating Assessment Tool (EAT-10) is a commonly utilized screening and outcome measure. To date, studies using classic test theory methodologies report good psychometric properties, but the EAT-10 has not been evaluated using item respon

The Subject in International Law : The Administrator of the Coalition Provisional Authority of Occupied Iraq and its Laws

In the wake of the war and occupation of Iraq, 2003–2004, international legal scholars struggled to understand and adequately describe the event and the law surrounding it. This study takes that situation of uncertainty as its point of departure, and it unfolds through an analysis of the material conditions and linguistic–rhetoric and affective–psychic registers through which the Administrator of In the wake of the war and occupation of Iraq, 2003–2004, international legal scholars struggled to understand and adequately describe the event and the law surrounding it. This study takes that situation of uncertainty as its point of departure, and it unfolds through an analysis of the material conditions and linguistic–rhetoric and affective–psychic registers through which the Administrator of

Forming chondrules in impact splashes-II Volatile retention

Solving the mystery of the origin of chondrules is one of the most elusive goals in the field of meteoritics. Recently, the idea of planet(esimal) collisions releasing splashes of lava droplets, long considered out of favor, has been reconsidered as a possible origin of chondrules by several papers. One of the main problems with this idea is the lack of quantitative and simple models that can be u