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High glucose and free fatty acids induce beta-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor
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Abstract in Danish Mennesket bruger i dag bioreaktorer til effektivt at kontrollere en biokemisk proces. Den kunst har bladskærermyrer i Sydamerika allerede lært for mange millioner år siden ved at dyrke svampehaver i deres bo.
A high-density tissue microarray from patients with clinically localized prostate cancer reveals ERG and TATI exclusivity in tumor cells.
Background:Prostate cancer (PCa) is characterized by high tumor heterogeneity. In 2005, the fusion between the androgen-regulated gene TMPRSS2 and members of the ETS family was discovered in prostate cancer. In particular, fusion of TMPRSS2 with ERG was found in approximately 50% of prostate cancers and considered as an early event in the onset of the disease. The prognostic value of this fusion i
Experimental productivity rate optimization of rare earth element separation through preparative solid phase extraction chromatography.
Separating individual rare earth elements from a complex mixture with several elements is difficult and this is emphasized for the middle elements: Samarium, Europium and Gadolinium. In this study we have accomplished an overloaded one-step separation of these rare earth elements through preparative ion-exchange high-performance liquid chromatography with an bis (2-ethylhexyl) phosphoric acid impr
Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
AIMS/HYPOTHESIS: Several genome-wide linkage studies have shown an association between diabetic nephropathy and a locus on chromosome 18q harbouring two carnosinase genes, CNDP1 and CNDP2. Carnosinase degrades carnosine (β-alanyl-L-: histidine), which has been ascribed a renal protective effect as a scavenger of reactive oxygen species. We investigated the putative associations of genetic variants
An in situ sample environment reaction cell for spatially resolved x-ray absorption spectroscopy studies of powders and small structured reactors.
An easy-to-use sample environment reaction cell for X-ray based in situ studies of powders and small structured samples, e.g., powder, pellet, and monolith catalysts, is described. The design of the cell allows for flexible use of appropriate X-ray transparent windows, shielding the sample from ambient conditions, such that incident X-ray energies as low as 3 keV can be used. Thus, in situ X-ray a
CFD-modelling of natural convection in a groundwater-filled borehole heat exchanger
In design of ground-source energy systems the thermal performance of the borehole heat exchangers is important. In Scandinavia, boreholes are usually not grouted but left with groundwater to fill the space between heat exchanger pipes and borehole wall. The common U-pipe arrangement in a groundwater-filled BHE has been studied by a three-dimensional, steady-state CFD model. The model consists of a
Ethnic matching in the US venture capital market
We document the role of entrepreneurial founder and venture capital (VC) partner co-ethnicity in shaping investment relationships. Co-ethnicity increases the likelihood that a VC firm invests in a company. Conditional on investment, co-ethnicity strengthens the degree of involvement by raising the likelihood of VC board of director involvement and increasing the size and scope of investment. These
Effect of stress on NiO reduction in solid oxide fuel cells: a new application of energy-resolved neutron imaging
Recently, two new phenomena linking stress field and reduction rates in anode-supported solid oxide fuel cells (SOFCs) have been demonstrated, so-called accelerated creep during reduction and reduction rate enhancement and nucleation due to stress (Frandsen et al., 2014). These complex phenomena are difficult to study and it is demonstrated here that energy-resolved neutron imaging is a feasible t
Common data items in seven European oesophagogastric cancer surgery registries: Towards a European Upper GI cancer audit (EURECCA Upper GI).
Seven countries (Denmark, France, Ireland, the Netherlands, Poland, Sweden, United Kingdom) collaborated to initiate a EURECCA (European Registration of Cancer Care) Upper GI project. The aim of this study was to identify a core dataset of shared items in the different data registries which can be used for future collaboration between countries.
Does drinking affect long-term sickness absence? A sample selection approach correcting for employment and accounting for drinking history
This article studies the effect of alcohol consumption on the probability of long-term sickness-related absenteeism for women. Using Swedish matched survey and register data, we apply sample selection models to correct for nonrandom sampling into paid employment. There are three main findings of the study. First, diverging from the most prevalent consumption group (long-term light drinkers) is ass
Corridor or drift fence? The role of medial moraines for fly dispersal over glacier
Corridors are often considered to promote dispersal between habitat patches. In this paper, we study whether or not corridors induce colonisation of nunataks (ice-free areas in glacier surroundings) by promoting dispersal from lowland to the nunataks. On outlet glaciers, debris originating from nunataks forms the so-called medial moraines that stretch from the nunataks down-glacier to the lowland,
Combination of novel HER2-targeting antibody 1E11 with trastuzumab shows synergistic antitumor activity in HER2-positive gastric cancer.
The synergistic interaction of two antibodies targeting the same protein could be developed as an effective anti-cancer therapy. Human epidermal growth factor receptor 2 (HER2) is overexpressed in 20-25% of breast and gastric cancer patients, and HER2-targeted antibody therapy using trastuzumab is effective in many of these patients. Nonetheless, improving therapeutic efficacy and patient survival
Observation of Associated Near-Side and Away-Side Long-Range Correlations in root S-NN=5.02 TeV Proton-Lead Collisions with the ATLAS Detector
Two-particle correlations in relative azimuthal angle (Delta phi) and pseudorapidity (Delta eta) are measured in root S-NN = 5.02 TeV p + Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 mu b(-1) of data as a function of transverse momentum (p(T)) and the transverse energy (Sigma E-T(Pb)) summed over 3.1 < eta < 4.9 in the direction of the Pb
APC-PCI complex levels for screening of AAA in patients with peripheral atherosclerosis.
To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13 % of patients. Aortic diameter correla
Smoking and Chronic Pain Among People Aged 65 Years and Older.
OBJECTIVE: To study the relationship between smoking and chronic pain among people aged 65+ years. DESIGN: A cross-sectional study. SAMPLE: The study was carried out in 2011 and included a randomly selected (N = 2000, response rate 57%) sample of people aged 65 years and older, living in Sweden. MEASUREMENT: A postal questionnaire with questions about demographic data, living conditions, tobacco u
Methods for the preparation of chlorophyllide a: an intermediate of the chlorophyll biosynthetic pathway
Chlorophyllide a is a metabolite late in the biosynthesis of chlorophylls and bacteriochlorophylls. Isolation procedures for chlorophyllide a from Rhodobacter capsulatus CB1200 and barley (Hordeum vulgare L.) are described and compared. R. capsulatus CB1200 is a double mutant in the bacteriochlorophyllide a biosynthetic pathway, and chlorophyllide a is excreted by the cells when grown in Tween 80-
Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk.
Contrasting diversity patterns of epigeic arthropods between grasslands of high and low agronomic potential
Abstract in UndeterminedIncreasing demand for food, fuel and fibre promotes the intensification of land-use, particularly in areas favourable for agricultural production. In less-favourable areas, more wildlife-friendly farming systems are often either abandoned or under pressure of conversion, e.g. for bioenergy production. This raises the question, to which extent areas of different agronomicpot
