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Cell Sorting in Pillar Arrays based on Electrokinetics and Morphology
Deterministic Lateral Displacement (DLD) is a method capable of sorting cells based on size where mechanicalinteractions between a sufficiently large particle and obstacles in a microfludic pillar array force the particle tofollow a different trajectory than their smaller counterparts, resulting in continuous lateral separation. To extendthe capability of DLD, electrical interaction between partic
Growth factor signaling in the breast tumor microenvironment
Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. In the clinical setting, disease management has heavily relied on the sole targeting of malignant cells but, except
Automatic classification using DDC on the Swedish union catalogue
With more and more digital collections of various information resources becoming available, also increasing is the challenge of assigning subject index terms and classes from quality knowledge organization systems. While the ultimate purpose is to understand the value of automatically produced Dewey Decimal Classification (DDC) classes for Swedish digital collections, the paper aims to evaluate th
From production planning flows to manufacturing operation management KPIs : linking ISO18828 & ISO22400 standards
International standards are playing a key role in leading and shaping the smart manufacturing landscape. The integration and consistency among different standards is therefore essential to effectively support industrial automation evolution and to ensure their applicability. This paper focuses on the ISO18828 and ISO22400 standards, related to the production planning process and manufacturing, con
Highly Sensitive Membraneless Fructose Biosensor Based on Fructose Dehydrogenase Immobilized onto Aryl Thiol Modified Highly Porous Gold Electrode : Characterization and Application in Food Samples
In this paper we present a new method to electrodeposit highly porous gold (h-PG) onto a polycrystalline solid gold electrode without any template. The electrodeposition is carried out by first cycling the electrode potential between +0.8 and 0 V in 10 mM HAuCl4 with 2.5 M NH4Cl and then applying a negative potential for the production of hydrogen bubbles at the electrode surface. After that the m
Efficient parallel algorithm for pixel classification in remote sensing imagery
An important approach for image classification is the clustering of pixels in the spectral domain. Fast detection of different land cover regions or clusters of arbitrarily varying shapes and sizes in satellite images presents a challenging task. In this article, an efficient scalable parallel clustering technique of multi-spectral remote sensing imagery using a recently developed point symmetry-b
Cancer gene expression data analysis using rough based symmetrical clustering
Identification of cancer subtypes is the central goal in the cancer gene expression data analysis. Modified symmetry-based clustering is an unsupervised learning technique for detecting symmetrical convex or non-convex shaped clusters. To enable fast automatic clustering of cancer tissues (samples), in this chapter, the authors propose a rough set based hybrid approach for modified symmetry-based
Identification of conserved gene clusters in multiple genomes based on synteny and homology
Background: Uncovering the relationship between the conserved chromosomal segments and the functional relatedness of elements within these segments is an important question in computational genomics. We build upon the series of works on gene teams and homology teams.Results: Our primary contribution is a local sliding-window SYNS (SYNtenic teamS) algorithm that refines an existing family structure
Spectral clustering on neighborhood kernels with modified symmetry for remote homology detection
Remote homology detction among proteins in an unsupervised approach from sequences is an important problem in computational biology. The existing neighborhood cluster kernel methods and Markov clustering algorithms are most efficient for homolog detection. Yet they deviate from random walks with inflation or similarity depending on hard thresholds. Our spectral clustering approach with new combine
Evolutionary rough parallel multi-objective optimization algorithm
A hybrid unsupervised learning algorithm, which is termed as Parallel Rough-based Archived Multi-Objective Simulated Annealing (PARAMOSA), is proposed in this article. It comprises a judicious integration of the principles of the rough sets theory and the scalable distributed paradigm with the archived multi-objective simulated annealing approach. While the concept of boundary approximations of ro
Gene Microarray Data Analysis Using Parallel Point Symmetry-Based Clustering
The PanCareSurFup consortium : research and guidelines to improve lives for survivors of childhood cancer
Background: Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing mu
Bridging the gap : citizenship diversity and global innovation networks in small and medium size companies
Recent literature stresses the increasing importance of global innovation networks (GINs) as a mechanism to organize innovation across geographical space. This paper investigates why and to what extent citizenship diversity of the firm's employees relates to the engagement of small and medium size companies in GINs. Citizenship diversity provides knowledge about the institutional context of other
Neutron-deficient N≈126 Nuclei Produced in 238U Fragmentation : Population of High-spin States
The population of metastable states produced in relativistic-energy fragmentation of a 238U beam has been measured. For states with high angular momentum, I=17 and I=21.5, a higher population than expected has been observed, with the discrepancy increasing with angular momentum. By considering two sources for the angular momentum, related to single-particle and collective motions, a much improved
PanCareLIFE: The scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents
Aims: Survival after cancer diagnosed during childhood or adolescence continues to improve with new treatments and supportive therapies. Optimal long-term care requires that risks to vulnerable organs are clearly defined and translated into guidelines that are implemented into practice. PanCareLIFE is a pan-European consortium that addresses survivorship issues comprising fertility, hearing impair
Exotic Nuclear Studies Around and Below A=100
A RISING experiment with an aim to study exotic Cd nuclei was carried out at GSI-FRS facility. Some preliminary results from this experiment are presented here. In particular, the β decay of 96Cd to 96Ag revealed the existence of a high spin isomer predicted a few decades ago. In this context, the structures of both these nuclei are discussed. Shell model calculations using the Gross-Frenkel inter
Whole genome sequencing reveals DICER1 as a candidate predisposing gene in familial Hodgkin lymphoma
Structure of N≥126 Nuclei Produced in Fragmentation of 238U
The nuclear structure of neutron-rich N≥126 nuclei have been investigated following their production via relativistic projectile fragmentation of a E/A=l GeV 238U beam on a Be target. The cocktail of secondary beam products were separated and identified using the GSI FRagment Separator (FRS). The nuclei of interest were implanted in a high-granularity active stopper detector set-up consisting of 6
2D polarization imaging as a low-cost fluorescence method to detect α-synuclein aggregation ex vivo in models of Parkinson’s disease
A hallmark of Parkinson’s disease is the formation of large protein-rich aggregates in neurons, where α-synuclein is the most abundant protein. A standard approach to visualize aggregation is to fluorescently label the proteins of interest. Then, highly fluorescent regions are assumed to contain aggregated proteins. However, fluorescence brightness alone cannot discriminate micrometer-sized region
