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Since antibiotic resistance is often associated with a fitness cost, bacteria employ multi-layered regulatory mechanisms to ensure that expression of resistance factors is restricted to times of antibiotic challenge. In Bacillus subtilis, the chromosomally-encoded ABCF ATPase VmlR confers resistance to pleuromutilin, lincosamide and type A streptogramin translation inhibitors. Here we show that vm

Over the years, remanufacturing practices have grown in popularity in industrial areas. It is one of the most effective ways to keep products out of landfills by turning end-of-life items into usable products. However, the available literature on cost models is limited or specific to a product. A general cost model for remanufacturing is presented in this paper to understand the major costs involvOver the years, remanufacturing practices have grown in popularity in industrial areas. It is one of the most effective ways to keep products out of landfills by turning end-of-life items into usable products. However, the available literature on cost models is limited or specific to a product. A general cost model for remanufacturing is presented in this paper to understand the major costs involv

The seventeenth and eighteenth centuries are the golden age of the poetic epitaph in Sweden and Europe. Most epitaphs were shaped in accordance with the principle of decorum, i.e., they were written to praise the dead and to comfort the bereaved. But there were also poems that sought to instead find faults with the deceased, sometimes even to insult their memory. A form of funeral poetry that was

The Swedish higher education sector is in a phase in which the importance of external engagement for quality in research and education at universities has gradually become clearer. This development is also visible at European as well as global level. It is therefore relevant to assess and value the work that takes place at universities within the framework of external engagement and to support a d

Genome editing is a powerful new tool allowing precise additions, deletions and substitutions in the genome. The development of new approaches has made editing of the genome much more precise, efficient, flexible, and less expensive, relative to previous strategies. As with other medical advances, each such application comes with its own set of benefits, risks, ethical issues and societal implicat

6G systems, such as Large Intelligent Surfaces, will require distributed, complex, and coordinated decisions throughout a very heterogeneous and cell free infrastructure. This will require a fundamentally redesigned software infrastructure accompanied by massively distributed and heterogeneous computing resources, vastly different from current wireless networks.To address these challenges, in this6G systems, such as Large Intelligent Surfaces, will require distributed, complex, and coordinated decisions throughout a very heterogeneous and cell free infrastructure. This will require a fundamentally redesigned software infrastructure accompanied by massively distributed and heterogeneous computing resources, vastly different from current wireless networks.To address these challenges, in this

Evaluation of information systems is crucial in solving challenges, informing policy and measuring return on investments in information systems. This paper carries out a systematic literature review in the evaluation of interoperability in health information systems and utilizes the parsimonious Delone and Mclean Success Model to present its findings. Key among the evaluation measures identified w

Economic research on gender largely focuses on biological sex, the binary classification as either a "man" or "woman." We investigate the value of incorporating a measure of continuous gender identity (CGI) into economics by exploring whether it explains variation in economic preferences and behavior beyond the explanatory power of binary sex. First, we validate a novel single-item CGI measure in

Monitoring of low-molecular weight cancer biomarkers, such as tryptophan (Trp) and its derivative kynurenine (Kyn), might be advantageous to non-invasive skin cancer detection. Thus, we assessed several approaches of topical sampling of Trp and Kyn, in relation to phenylalanine (Phe) and tyrosine (Tyr), on the volar forearm of six healthy volunteers. The sampling was performed with three hydrogels

Pitch and voice quality are increasingly understood as closelyintertwined. While Swedish and Norwegian word accents have traditionally been understood in terms of pitch, Danish stød, which is systematically related when it comes to distribution and function, has been described as a type of creaky voice. According to the Laryngeal Articulator Model (LAM), both pitch lowering and creaky or harsh voi

Objectives Osteoarthritis (OA) patient stratification is an important challenge to design tailored treatments and drive drug development. Biochemical markers reflecting joint tissue turnover were measured in the IMI-APPROACH cohort at baseline and analysed using a machine learning approach in order to study OA-dominant phenotypes driven by the endotype-related clusters and discover the driving fea

G protein-coupled receptor 55 (GPR55) probably plays a role in innate immunity and tumor immunosurveillance through its effect on immune cells, such as T cells and NK cells. In this study, the prognostic value of GPR55 in colon cancer (CC) was investigated. mRNA expression levels of GPR55 were determined in 382 regional lymph nodes of 121 CC patients with 12 years observation time after curative s

Background: The global burden of cardiovascular disease and type 2 diabetes could be decreased by improving dietary factors, but identification of groups suitable for interventional approaches can be difficult. Reporting of dietary intake is prone to errors, and measuring of metabolites has shown promise in determining habitual dietary intake. Our aim is to create a metabolic signature that is ass