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The type III receptor tyrosine kinase FLT3 is one of the most commonly mutated oncogenes in acute myeloid leukemia (AML). Inhibition of mutated FLT3 in combination with chemotherapy has displayed promising results in clinical trials. However, one of the major obstacles in targeting FLT3 is the development of resistant disease due to secondary mutations in FLT3 that lead to relapse. FLT3 and its on
The Fiskarheden quarry, situated in NW Dalarna, central Sweden, reveals thick coarse-grained sediments of Scott type facies association representing a sandur deposited in an ice-proximal proglacial environment. Optically Stimulated Luminescence (OSL) dating of the sandur sediments suggests a pre-Last Glacial Maximum (LGM) age. Most acquired ages are pre-Saalian (>200 ka) and we regard each of thes
Volymen lyfter fram några aspekter av hur kyrkoåret har uppfattats, främjats och reviderats under det senaste seklet. Artiklarna belyser kyrkoårets gestaltning i predikoutkast, evangeliebok, folklig sed, sång, musik och liturgiska textilier. Dessutom finns en fyllig recensionsavdelning.
Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to define the heterogeneity within the LSC-population in chronic phase chronic myeloid
Background: Residual air accumulated air in the pulmonary veins constitutes a challenge to achievment of complete de-airing in open left heart surgery. To adress this problem, a conceptual method for de-airing was developed in Lund comprising bilateral opening of the pleurae to induce pulmonary collapse and a strategy with gradual pulmonary reperfusion and ventilation at weaning from cardiopulmona
Artikeln analyserar hur Augustinus i Sermo 9 hanterar människolivets paradoxer och svårigheter i relation till Guds löfte om evigt liv.Augustine mainly addressed men of the upper and middle classes. Their wives are assumed to be present (and, frequently, to be more pious than their husbands), but are seldom directly addressed. Servants and beggars are not addressed either, but stood to benefit from admonitions to the men in the audience, e.g. that they should give alms regularly and not sexually abuse their subordinates. All this
A survey of the Latin Lives of St Birgitta of Sweden, with an edition of a brief life found in an English ms. and another found in two Italian mss., both previously unedited. Also a re-edition of the Life found in the first edition of St Birgitta's Revelations, published in 1492.
Python can be used for more than just general-purpose programming. It is a free, open source language and environment that has tremendous potential for use within the domain of scientific computing. This book presents Python in tight connection with mathematical applications and demonstrates how to use various concepts in Python for computing purposes, including examples with the latest version of
Large carnivore populations, such as wolf (Canis lupus) and brown bear (Ursus arctos), have during the last decades increased in Scandinavia. This has led to an intensified debate about the presence of large carnivores as well as about large carnivore policy and management. To some people large carnivores are associated with positive feelings such as interest and joy. To others the presence of lar
The marketing materials of remote eye-trackers suggest that data quality is invariant to the position and orientation of the participant as long as the eyes of the participant are within the eye-tracker's headbox, the area where tracking is possible. As such, remote eye-trackers are marketed as allowing the reliable recording of gaze from participant groups that cannot be restrained, such as infan
