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Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an unmet need of biomarkers that can aid in the diagnostic and prognostic assessment of the disease and response to treatment. In this two-part explorative proteomic study, we demonstrate how proteins associated with tissue remodeling, inflammation and chemotaxis such as MMP7, CXCL13 and CCL19 are released in response

Online routing in a planar embedded graph is central to a number of fields and has been studied extensively in the literature. For most planar graphs no O(1)-competitive online routing algorithm exists. A notable exception is the Delaunay triangulation for which Bose and Morin (SIAM J Comput 33(4):937–951, 2004) showed that there exists an online routing algorithm that is O(1)-competitive. However

Three-dimensional brain organoids have emerged as a valuable model system for studies of human brain development and pathology. Here we establish a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons. Using single cell RNA sequencing, we identify the presence of three molecularly distinct subtypes of human dopamine neurons w

Kursbok om Alternativ och Kompletterande Kommunikation (AKK), med fokus på kommunikationshjälpmedel, praktiska metoder och förhållningssätt. Boken ingår i ett kursmaterial i tre delar, för utbildning av personliga assistenter och andra som arbetar och lever nära ungdomar och vuxna med omfattande kommunikationssvårigheter på grund av funktionsnedsättning.

Background Lifestyle exposures play a major role in the development of disease, yet people vary in their susceptibility. A critical step towards precision medicine is identifying individuals who are resilient or sensitive to the environment, and, assess whether the allocation to these predicted groups are more or less likely to develop cardiometabolic disease.Methods We have used repeated data fro

The studies of incoherent single-particle and collective multi-particle effects are, in general, separated in accelerator beam dynamics in that the two dynamical phenomena involve quite different time scales. Recent experimental measurements indicate that in some parameter regime, the small-angle, multiple scattering effects within a high-brightness electron beam can have a strong influence on mic

The first online segmentation multi-target tracking algorithm with reported real-time speeds is presented. Based on the popular and fast bounding box based tracker SORT, our method called SORTS is able to utilize segmentations for tracking while keeping the real-time speeds. To handle occlusions, which neither SORT nor SORTS do, we also present SORTS+RReID, an optional extension which uses ReID ve

Telomere erosion has been proposed to be tightly associated with senescence, environmental stressors and life history trade-offs. How telomere dynamics vary across life stages and especially in relation to (heritable) phenotypic traits is still unclear. The tawny owl Strix aluco display a highly heritable melanin-based colour polymorphism, a grey and a brown morph, linked to several fitness traits

Background: The risk of sustaining a contra-lateral anterior cruciate ligament (C-ACL) injury after primary unilateral ACL injury is high. C-ACL injury often contributes to a further decline in function and quality of life, including failure to return to sport. There is, however, very limited knowledge about which risk factors that contribute to C-ACL injury. Objective: To systematically review in

This paper focuses on path development processes after a sudden path exhaustion. We analyse the decline, the closure and the attempts at the re-orientation of a forestry-based industry agglomeration in Southern Norway, located around the municipality of Hønefoss. In particular, this paper focuses on the Treklyngen holding company in Hønefoss. This paper explores how policy may be influenced by and

Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migrai

The resurgence of radical and populist parties has stimulated renewed discussions about the resilience of parliamentary democracy in Europe. This work contributes to this debate by analysing the extent to which positive parliamentarism, the prime minister’s parliamentary dissolution powers, the government’s power to table votes of confidence and the majority requirements for votes of no confidence

Increasing demand for detecting single molecules in challenging environments has raised the bar for the fluorophores used. To achieve better resolution and/or contrast in fluorescence microscopy, it is now essential to use bright and stable dyes with tailored photophysical properties. While long fluorescence lifetime fluorophores offer many advantages in time-resolved imaging, their inherently low

Gliomas are the most common intracranial primary tumors, for which very few therapeutic options are available. The most malignant subtype is the glioblastoma, a disease associated with a 5-year survival rate lower than 5%. Given that research in glycobiology continues highlighting the role of glycans in tumor cell biology, it offers an interesting niche for the search of new therapeutic targets. I

The transition of free-living organisms to parasitic organisms is a mysterious process that occurs in all major eukaryotic lineages. Parasites display seemingly unique features associated with their pathogenicity; however, it is important to distinguish ancestral preconditions to parasitism from truly new parasite-specific functions. Here, we sequenced the genome and transcriptome of anaerobic fre

In this article we describe the system of point vortices, derived by Helmholtz from the Euler equation, and their associated Gibbs measures. We discuss solution concepts and available results for systems of point vortices with deterministic and random circulations, and further generalizations of the point vortex model.

We analyze a semidiscrete scheme for the Cahn-Hilliard equation in one space dimension, when the interface length parameter is equal to zero. We prove convergence of the scheme for a suitable class of initial data, and we identify the limit equation. We also characterize the long-time behavior of the limit solutions.

We study the convergence of a semidiscrete scheme for the forward-backward parabolic equation ut = (W?(ux))x with periodic boundary conditions in one space dimension, where W is a standard double-well potential. We characterize the equation satised by the limit of the discretized solutions as the grid size goes to zero. Using an approximation argument, we show that it is possible to flow initial d